Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Lastly, BPC 157 counteracts tumor cachexia, muscle wasting, and increases in pro-inflammatory/procachectic cytokines, such as interleukin-6 and tumor necrosis factor-α, and significantly corrects deranged muscle proliferation and myogenesis through changes in the expression of FoxO3a, p-AKT, p-mTOR, and P-GSK-3β (mitigating cancer cachexia).
|
31158953 |
2020 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The transcription factor FOXO3 has been associated in different tumor entities with hallmarks of cancer, including metastasis, tumor angiogenesis, maintenance of tumor-initiating stem cells, and drug resistance.
|
31591479 |
2020 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
FoxO3a is a well-defined tumor suppressor gene in the forkhead transcription factor O subfamily (FoxO), and its reduction is related to the occurrence of various tumors.
|
31771044 |
2020 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings highlight that PP2A antagonizes the prosurvival pathways controlled by Akt, which phosphorylates and thereby suppresses a variety of pro-apoptotic factors and tumour suppressors including Bad and FoxO3a.
|
30353029 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, vascular endothelial cell-specific knockout of FoxO3a in mice could disrupt the anti-angiogenesis effect of As<sub>2</sub>O<sub>3</sub> and endow the tumors with resistance to As<sub>2</sub>O<sub>3</sub> treatments.
|
31421153 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings demonstrate that silencing FOXO3a promotes tumor radioresistance of NPC in vitro and in vivo through inducing EMT and activating Wnt/β-catenin signal pathway.
|
31022422 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The promoting effect might be elicited by activation of the insulin receptor and insulin-like growth factor-1 receptor and through the downstream Akt-signaling pathway, which inhibits the activity of the tumor-suppressor FoxO3a.
|
30260725 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The transcription factor forkhead box O 3A (FOXO3A) is a tumor suppressor that promotes cell cycle arrest and apoptosis.
|
30753811 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Forkhead Box O3 (FOXO3) is a tumor suppressor whose activity is fine-tuned by post-translational modifications (PTMs).
|
31357743 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Oncogenic Akt-FOXO3 loop favors tumor-promoting modes and enhances oxidative damage-associated hepatocellular carcinogenesis.
|
31488102 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
LINC01355 acts as a tumor suppressor in breast cancer, which is ascribed to enhancement of FOXO3-mediated transcriptional repression of CCND1.
|
31243265 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
FOXO3a has been widely regarded as a tumor suppressor.
|
31629677 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
FOXO3 is a tumor suppressor that orchestrates the expression of genes that regulate cell cycle progression, apoptosis, metabolism, oxidative stress, and other important cellular processes.
|
30414146 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Subsequently, FOXO3 may act as the functional target of miR-6506-5p, and the knockdown of hsa_circ_0001368 decreased the expression of the tumor-suppressive gene FOXO3.
|
30853185 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Mechanistically, apigenin upregulated the expression of Noxa in EGFRm tumor cells by targeting the AKT-FoxO3a pathway, thereby synergizing with ABT-263 to suppress tumor cell growth and proliferation in vitro and in vivo.
|
31367332 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Interestingly, knockdown of FOXO3a attenuated not only ING4-elicited tumor suppression but also ING4-mediated regulatory effect on FOXO3a downstream targets, confirming that FOXO3a is involved in ING4-directed tumor-inhibitory effect in HCC.
|
30745827 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Previous reports indicate that Forkhead box O3 (FOXO3) is involved in the development of various tumors and may have different effects depending upon the types of tumors.
|
30623608 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
FoxO3a is a well-defined tumor suppressor gene in the forkhead transcription factor O subfamily (FoxO), and its reduction is related to the occurrence of various tumors.
|
31599414 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The aim of the present study was to investigate the impact of miR-148a on tumor cell viability and invasion via targeting forkhead box protein O3 (FOXO3).
|
31289511 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tumor suppressor FOXO3a mediates the response to EGFR inhibition in glioblastoma cells.
|
30980364 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
HCC patients were collected for tumor and adjacent tissues, in which microRNA-155 (miR-155) and FoxO3a expressions were examined.
|
29565484 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings challenge the current paradigm that nuclear export regulates the proteolysis of FOXO3A/4 tumour suppressors in the context of cancer and illustrates how oncogenic RAS-mediated degradation of FOXOs, via post-translational mechanisms, blocks these important tumour suppressors.
|
28945225 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumor bearing mice hearts show increased expression and nuclear localization of TFEB and FoxO3a transcription factors, which are involved in the upregulation of muscle atrophy genes, lysosomal biogenesis genes and autophagy genes.
|
29618792 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The FOXO3 is a tumor suppressor gene and found to interact with p53, the trigger for apoptosis through BCl2 family genes and a regulator of Notch signaling pathway for the self-renewal of stem cells.
|
30205794 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
And systemic delivery of miR-10b-3p antagomir reduced tumor growth and inhibit FOXO3 protein expression in nude mice.
|
30514328 |
2018 |