|
Asthma
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Filaggrin mutations confer susceptibility to atopic dermatitis but not to asthma.
|
18073125 |
2007 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
Filaggrin gene mutations are associated with asthma and eczema in later life.
|
18760831 |
2008 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Filaggrin (FLG) loss-of-function variants (null-alleles) are associated with eczema and asthma in association with eczema.
|
19408338 |
2009 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
FLG mutations are also significantly associated with asthma (OR, 1.48; 95% CI, 1.32-1.66).
|
19501237 |
2009 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Filaggrin gene mutations also increased the risk of asthma in people with atopic eczema.
|
19589816 |
2009 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Filaggrin gene (FLG) mutations contribute to the development of eczema and asthma, but their contribution to sensitization and hay fever remains unclear.
|
19839980 |
2009 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Filaggrin null mutations associate with atopic eczema and also with asthma when present with eczema.
|
20500796 |
2010 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
AD, early-onset AD, palmar hyperlinearity, and asthma showed significant associations with the combined FLG null genotype.
|
27840886 |
2017 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Additional insights from rare monogenic disorders that can present as severe asthma include recognition that loss-of-function variants in the filaggrin gene known to cause ichthyosis vulgaris are consistently associated with more severe asthma outcomes.
|
30896504 |
2019 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Additional insights from rare monogenic disorders that can present as severe asthma include recognition that loss-of-function variants in the filaggrin gene known to cause ichthyosis vulgaris are consistently associated with more severe asthma outcomes.
|
31090575 |
2019 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
African-American (AA) children are disproportionately affected with AD, often later developing asthma and/or allergic rhinitis and comprise an atopy health disparity group for which the role of FLG LOF is not well known.
|
29791750 |
2018 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A yet unrecognized class of mid-onset-resolving AD, not associated with FLG mutations, but strongly associated with asthma, was identified.
|
29129583 |
2018 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Children with filaggrin variants had a marked and persistent increase in acute severe asthma exacerbations from 1 yr of age (incidence ratio 2.40 [1.19-4.81], p = 0.01) and increased risk of asthma by age 5 (odds ratio 2.62 [1.12-6.11], p = 0.03).
|
20573035 |
2010 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Children with nonallergic rhinitis also had increased asthma prevalence (20% vs 5%; P = .001) but showed no association with filaggrin null-mutations, eczema, food sensitization, total IgE, blood eosinophil count, FeNO, or bronchial responsiveness.
|
20816191 |
2010 |
|
Asthma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Early data suggest that FLG-associated eczema may be more persistent, more likely to have palmar hyperlinearity, and more likely to be associated with asthma.
|
17299430 |
2007 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Early food sensitization and the presence of an FLG mutation in infants with early eczema increase the risk for later asthma, but the combination of the 2 factors does not represent a clinically useful approach to reliably identify children at risk.
|
22030464 |
2011 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
Filaggrin mutations, atopic eczema, hay fever, and asthma in children.
|
18396323 |
2008 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.
|
30929738 |
2019 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Highly significant association of the filaggrin null mutations with eczema and concomitant asthma was replicated.
|
17030239 |
2006 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
However, little is known about the contribution of loss-of-function mutations in the gene encoding filaggrin (FLG) gene, which are considered to be predisposing factors for eczema and asthma, to these associations.
|
30195067 |
2018 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In fact, the exposure to environmental factors during early childhood may induce a long-lasting altered genetic state adapting to a persistent "Th2 state" thus influencing the development of asthma or atopic dermatitis and food allergy if alterations involve the filaggrin gene.
|
23809342 |
2013 |
|
Asthma
|
0.200 |
Biomarker
|
disease |
BEFREE |
In the filaggrin-asthma analysis, a direct effect of FLG-LOF mutations was observed on early childhood eczema (age 1 and 2 years) (relative risk (RR) 2.01, 95% CI: 1.74-2.31, P < .001), and all significant indirect pathways on asthma outcomes passed through eczema at these ages.
|
29266469 |
2018 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In the delayed-effects models, 'FLG variants plus allergic sensitization' and 'FLG variants plus eczema' increased the risk of subsequent asthma by 4.93-fold (95% CI 3.61-6.71) and 3.33-fold (95% CI 2.45-4.51), respectively, during the first 18 years of life.
|
25277085 |
2014 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In the Polish patients with AD, the prevalence of FLG mutations was higher in patients with AD than in the controls and 2282del4 FLG mutation was more frequent than R501X, and it was associated with a 6-fold higher risk for AD development (P < 0.001; OR: 5.76), moderate or severe disease course, early onset of asthma and palmar hyperlinearity.
|
21426411 |
2011 |