|
Acute Erythroblastic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results showed that C10 regulated the expression of Bax, c-Myc, Bcl-2, P38/AMPK and ERK 1/2, activated the expression of Caspase-3, -8, and PARP at the protein level in the apoptosis pathway of the two leukemia cell types, and inhibited the expression of erythroleukemia carcinogene Fli-1 in the human erythroleukemia cell line HEL.
|
29990873 |
2018 |
|
Acute Erythroblastic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, expression of Spi‑1/PU.1 in a Fli‑1 producing erythroleukemia cell line in which fli‑1 is activated, resulted in increased proliferation through activation of growth promoting proteins MAPK, AKT, cMYC and JAK2.
|
28586009 |
2017 |
|
Acute Erythroblastic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Aberrant expression of Fli-1 also underlies a number of virally induced leukemias, including Friend virus-induced erythroleukemia and various types of human cancers, and it is the target of chromosomal translocations in childhood Ewing's sarcoma.
|
24909161 |
2015 |
|
Acute Erythroblastic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Viral insertion at the fli-1 locus induces erythroleukemia in susceptible strains of mice.
|
23677281 |
2013 |
|
Acute Erythroblastic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The activation of Fli-1, an Ets transcription factor, is the critical genetic event in Friend murine leukemia virus (F-MuLV)-induced erythroleukemia.
|
20445019 |
2010 |
|
Acute Erythroblastic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results suggest, for the first time, an essential role for continuous Fli-1 overexpression in the maintenance and survival of the malignant phenotype in murine and human erythroleukemias.
|
19282832 |
2009 |
|
Acute Erythroblastic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The Ets transcription factor, Fli-1, has been shown to play a pivotal role in the induction and progression of Friend Murine Leukemia Virus (F-MuLV)-induced erythroleukemia, with its overexpression leading to erythroblast survival, proliferation, and inhibition of terminal differentiation.
|
15592502 |
2005 |
|
Acute Erythroblastic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Insertional activation at the FLI-1 locus is an early event in F-murine leukemia virus-induced erythroleukemia.
|
14570912 |
2004 |
|
Acute Erythroblastic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Retroviral insertional activation of Fli-1 and Spi-1/PU.1, as well as loss of tumour suppressor genes such as p53 or p45 NFE2 have been shown to be critical for the induction and progression of Friend virus-induced erythroleukemias.
|
12894591 |
2003 |
|
Acute Erythroblastic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Rearrangement of the FLI-1 locus and ensuing overexpression of FLI-1 protein is an early event in Friend murine leukemia virus (F-MuLV)-induced erythroleukemia.
|
12946994 |
2003 |
|
Acute Erythroblastic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
PU.1 was identified as a target of insertional activation in the majority of tumors induced by the murine Spleen Focus Forming virus (SFFV), while fli-1 proved to be the target of Friend murine leukemia virus (F-MuLV) in F-MuLV induced erythroleukemia, as well as that of the 10A1 and Graffi viruses.
|
11175363 |
2000 |
|
Acute Erythroblastic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The ETS gene Fli-1 is involved in the induction of erythroleukemia in mice by Friend murine leukemia virus and Ewings sarcoma in children.
|
10981960 |
2000 |
|
Acute Erythroblastic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Indeed, the etiology of a number of virally induced leukemias, including Friend virus-induced erythroleukemia, has been associated with Fli-1 overexpression.
|
11175364 |
2000 |
|
Acute Erythroblastic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We further suggest that deregulated synthesis of Fli-1 may trigger a common mechanism contributing to erythroleukemia induced by either SFFV or F-MuLV.
|
9858537 |
1999 |
|
Acute Erythroblastic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, the data suggest an indirect interaction between Fli-1 and RAR alpha mediated by a 'bridging' factor(s) present in nuclear extracts from RM10 erythroleukemia cells.
|
9444955 |
1997 |
|
Acute Erythroblastic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Activation of the Fli-1 gene by either chromosomal translocation or viral insertion leads to Ewing's sarcoma in humans and erythroleukemia in mice, respectively.
|
8524263 |
1995 |
|
Acute Erythroblastic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, PU.1 and FLI-1 are dysregulated by Friend leukemia virus insertion in mice resulting in erythroleukemia.
|
8086619 |
1994 |
|
Acute Erythroblastic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Fli-1 gene was found to be rearranged in 75% of the erythroleukemias induced by Friend murine leukemia virus (F-MuLV), suggesting that it could play a key role in cellular transformation.
|
8336942 |
1993 |
|
Acute Erythroblastic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fli-1, an ets related gene, was found to be rearranged in 75% of erythroleukemias induced by Friend murine leukemia virus.
|
7503813 |
1993 |
|
Acute Erythroblastic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Fli-1 is not rearranged or activated in the erythroleukemias induced by SFFV, and similarly Spi-1 is not rearranged or activated in the leukemic cell clones induced by F-MuLV.
|
8502483 |
1993 |
|
Acute Erythroblastic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mouse Fli-1 was shown to be involved in 75% erythroleukemias induced by Friend murine leukemia virus suggesting the possibility that Fli-1 may play a critical role in cellular transformation.
|
1394211 |
1992 |