Thrombocytopenia
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Consistent with recent literature, it adds supplemental data to confirm the crucial role of FLI1 and ETS1 in JS, namely FLI1 in thrombocytopenia and ETS1 in cardiopathy and immune deficiency.
|
30888095 |
2019 |
Thrombocytopenia
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Mean platelet volume was measured in thrombocytopenia with different genetic aetiologies, bilallelic BSS (bBSS) (n = 1), monoallelic BSS (mBSS) (n = 2), MYH9-related disorders (MYH9-RD) (n = 11), GFI1B-related thrombocytopenia (RT) (n = 15), FLI1-RT (n = 2), TUBB1-RT (n = 3), ITGA2B/ITGB3-RT (n = 1), RUNX1-RT (n = 2) and controls (n = 54). bBSS and 82% of MYH9-RD samples had MPD >4 μm which correlated with "IT with giant platelets."
|
29143464 |
2018 |
Thrombocytopenia
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Recently, heterozygote human <i>FLI1</i> mutations have been ascribed to cause thrombocytopenia.
|
28432223 |
2017 |
Thrombocytopenia
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Moreover, it is worth mentioning data on hypomorphic mutations of FLI1 and the association of single nucleotide polymorphisms, such as that identified in ACTN1, with thrombocytopenia.
|
27438527 |
2016 |
Thrombocytopenia
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
In this issue of Blood, Stevenson et al describe a family with a homozygous missense mutation in FLI1 that is associated with a platelet phenotype identical to the one observed in Paris-Trousseau syndrome, supporting existing evidence that FLI1 is directly involved in the mechanism of thrombocytopenia observed in this disease.
|
26494917 |
2015 |
Thrombocytopenia
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Fli1(+/-) mice displayed mild thrombocytopenia, as did Ets1(+/-)Fli1(+/-) animals.
|
26093983 |
2015 |
Thrombocytopenia
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Our findings suggest that alterations in FLI1 and RUNX1 may be common in patients with platelet dense granule secretion defects and mild thrombocytopenia.
|
24100448 |
2013 |
Thrombocytopenia
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Clonal chromosome anomalies affecting FLI1 mimic inherited thrombocytopenia of the Paris-Trousseau type.
|
22775407 |
2012 |
Thrombocytopenia
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Therefore, our findings do not support the traditional view of deletion size correlation in JBS or the causative role of FLI1, ETS1, NFRKB, and JAM3 deletion per se for the development of disease-related thrombocytopenia.
|
22887642 |
2012 |
Thrombocytopenia
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
MYH10 was also detected in platelets of patients with the Paris-Trousseau syndrome, a thrombocytopenia related to the deletion of the transcription factor FLI1 that forms a complex with RUNX1 to regulate megakaryopoiesis, whereas MYH10 persistence was not observed in other inherited forms of thrombocytopenia.
|
22677128 |
2012 |
Thrombocytopenia
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
The FLI1 gene, which is the most relevant gene for thrombocytopenia in Jacobsen syndrome, was neither deleted in family A nor in Patient 3.
|
21834034 |
2011 |
Thrombocytopenia
|
0.200 |
AlteredExpression
|
phenotype |
BEFREE |
Thrombocytopenia in mice lacking the carboxy-terminal regulatory domain of the Ets transcription factor Fli1.
|
20823267 |
2010 |
Thrombocytopenia
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Our data support previous hypotheses that FLI1 haploinsufficiency is responsible for thrombocytopenia in patients with JBS.
|
18792974 |
2008 |
Thrombocytopenia
|
0.200 |
AlteredExpression
|
phenotype |
BEFREE |
FLI1 monoallelic expression combined with its hemizygous loss underlies Paris-Trousseau/Jacobsen thrombopenia.
|
15232614 |
2004 |
Thrombocytopenia
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia.
|
10981960 |
2000 |
Thrombocytopenia
|
0.200 |
Biomarker
|
phenotype |
HPO |
|
|
|
Thrombocytopenia
|
0.200 |
GeneticVariation
|
phenotype |
CLINVAR |
|
|
|