|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The close proximity of ZBTB16 and FLI-1 genes on chromosome 11q may explain the overexpression of ZBTB16 in PNET, especially in pPNET with t(1122) translocation.
|
31326195 |
2019 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Expression of FLI-1 has been demonstrated in Ewing's sarcoma/primitive neuroectodermal tumor (ES/PNET) and vascular neoplasms.
|
28605142 |
2017 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Ewing's sarcoma family tumors (ESFTs), which include peripheral primitive neuroectodermal tumors (PNETs), are characterized by chromosomal translocations that generate fusions between the EWS gene and ETS-family transcription factors, most commonly FLI1.
|
21979944 |
2012 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Herein, we describe a DSRCT in the maxilla of a young man, who was initially diagnosed with a primitive neuroectodermal tumor (PNET), based on histopathological appearance of a round cell tumor, with MIC2 and -FLI-1 positivity, on immunohistochemistry (IHC).
|
20739766 |
2010 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.500 |
Biomarker
|
disease |
BEFREE |
Establishing histological diagnosis can be difficult; CD99 and FLI1 immunohistochemical staining has improved diagnosis, but these markers are not specific for EFTs.
|
19411158 |
2009 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Friend leukemia virus integration-1 can be expressed in a variety of tumors, and is helpful in making the diagnosis of Ewing's sarcoma/primitive neuroectodermal tumor.
|
19530039 |
2009 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.500 |
Biomarker
|
disease |
BEFREE |
This undifferentiated sarcoma shows some features of Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET), including a diffuse reactivity for FLI1, but it shows only focal and weak reactivity for CD99 and is negative for a rearrangement of EWS, the molecular signature of ES/PNET.
|
17990934 |
2008 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Interphase and metaphase fluorescent in situ hybridization (FISH) studies performed on the pretreatment and posttreatment samples showed the presence of a t(11;22) rearrangement resulting in EWSR1/FLI1 gene fusion consistent with pPNET/EWS in both specimens.
|
16944972 |
2006 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.500 |
Biomarker
|
disease |
BEFREE |
Immunohistochemical staining was positive for vimentin, synapsin, CD99 (MIC2 protein), and FLI-1, prompting an initial diagnosis of Ewing sarcoma/primitive neuroectodermal tumor.
|
15642398 |
2005 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Ewing sarcoma (ES) and peripheral primitive neuroectodermal tumors (PNETs) are associated with a chromosomal translocation resulting in a fusion of the amino-terminus of EWS with the DNA-binding domain of an ETS transcription factor (most commonly FLI1 or ERG).
|
12557222 |
2003 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Virtually all cases of Ewing's Sarcoma and peripheral Primitive Neuroectodermal Tumor (PNET) are associated with aberrant transcription factors which fuse amino-terminal EWS with the DNA binding moiety of an ETS transcription factor (FLI-1 in 90% of cases).
|
11313995 |
2001 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Ewing sarcoma and other peripheral primitive neuroectodermal tumors (pPNETs) display limited neural differentiation and are thought to have a neural crest origin Greater than 95% of these tumors share common t(11;22)(q24;q12) ort(21;22)(q22;q12) chromosomal translocations leading to ES/FLI1 or EWS/ERG gene fusions, respectively.
|
9496833 |
1998 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
As a result of the t(11;22)(q24;q12) chromosomal translocation characterizing the Ewing family of tumors (ET), the amino terminal portion of EWS, an RNA binding protein of unknown function, is fused to the DNA-binding domain of the ets transcription factor Fli1.
|
9704926 |
1998 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.500 |
Biomarker
|
disease |
BEFREE |
In more than 95% of patients, the Ewing family of tumors (ET) has chimeric transcripts caused by fusion of the EWS gene to either FLI1 or ERG.
|
9836070 |
1998 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.500 |
FusionGene
|
disease |
ORPHANET |
Is the EWS/FLI-1 fusion transcript specific for Ewing sarcoma and peripheral primitive neuroectodermal tumor? A report of four cases showing this transcript in a wider range of tumor types.
|
8644855 |
1996 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Greater than 95% of pPNETs carry t(11;22) or t(21;22) chromosomal translocations which fuse the EWS gene from chromosome 22q12 in-frame with either FLI1 from chromosome 11q24 or ERG from chromosome 21q22.
|
7882340 |
1995 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In Ewing's sarcomas and related peripheral primitive neuroectodermal tumors, a t(11;22) translocation or a (21,22) rearrangement is associated with hybrid transcripts of the EWS gene with the FLI1 or ERG gene.
|
8022439 |
1994 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.500 |
FusionGene
|
disease |
ORPHANET |
To this end, we have tested pPNETs for the presence of EWS/FLI-1 fusion transcripts by reverse transcriptase-polymerase chain reaction (RT-PCR) using EWS and FLI-1 specific primers.
|
7506981 |
1993 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.500 |
Biomarker
|
disease |
BEFREE |
Using oligonucleotide primers derived from EWS and FLI-1 complementary DNAs, we were able to amplify a specific fusion transcript from 18 of 18 cases containing t(11;22) and 10 of 14 cases of Ewing's sarcoma/PNET that had unsuccessful cytogenetics.
|
8238248 |
1993 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.500 |
Biomarker
|
disease |
BEFREE |
To this end, we have tested pPNETs for the presence of EWS/FLI-1 fusion transcripts by reverse transcriptase-polymerase chain reaction (RT-PCR) using EWS and FLI-1 specific primers.
|
7506981 |
1993 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|