|
Malignant neoplasm of soft tissue
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Ewing sarcoma is the prototype of round cell sarcoma whereas in CIC sarcomas, focal pleomorphism and epithelioid morphology can predominate.
|
31802230 |
2020 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
CIC fusion-positive sarcoma of the spermatic cord.
|
30310990 |
2019 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
BCOR-rearranged sarcomas, CIC-fused sarcomas) and describes new groups with common characteristics.
|
30474142 |
2019 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
The diagnosis of sarcoma with CIC-DUX4 gene fusion is difficult in lack of specific pathological characteristics emphasizing the need for molecular analysis.
|
28466754 |
2019 |
|
Malignant neoplasm of soft tissue
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Primitive round- or spindle-cell EWSR1-negative undifferentiated sarcomas harboring CIC-DUX4 gene fusion are the most common form of Ewing-like sarcomas.
|
28474974 |
2019 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
In light of morphologic features that overlap with those of NC from typical anatomical sites we have seen previously, the tumor was best classified as falling within the NC spectrum rather than CIC-associated sarcoma.
|
29700887 |
2018 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
CIC-rearrangement by FISH was observed in many of the CIC-rearranged sarcomas.
|
29661713 |
2018 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
The CIC-DUX4 sarcoma is a small round blue cell sarcoma which presents like extraskeletal Ewing sarcoma, but is negative for the EWSR1 gene translocation.
|
30353686 |
2018 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
Herein, we describe the clinicopathologic features and comprehensive molecular profiling of 4 cases of primary renal CIC-rearranged sarcomas.
|
29901569 |
2018 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
Unsupervised clustering by RNAseq data revealed that tumors with BCOR genetic alterations, including BCOR-CCNB3, BCOR-MAML3, and BCOR ITD, formed a tight genomic group distinct from ES and CIC-rearranged sarcomas.
|
29300189 |
2018 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
As such the WHO classification temporarily grouped the CIC-rearranged tumors under undifferentiated sarcomas with round cell phenotype, until further clinical evidence was available.
|
28346326 |
2017 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, NKX2.2, ETV4 and BCOR IHC may be helpful in daily practice for distinguishing ESFT from CIC or BCOR-associated sarcomas, especially in hospitals without access to molecular assays.
|
28864350 |
2017 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
We estimated that the FISH false-negative rate for CIC-rearranged sarcomas was 14%.
|
28493604 |
2017 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
<i>CIC-DUX4</i> Induces Small Round Cell Sarcomas Distinct from Ewing Sarcoma.
|
28404587 |
2017 |
|
Malignant neoplasm of soft tissue
|
0.100 |
GeneticVariation
|
group |
BEFREE |
ETV transcriptional upregulation is more reliable than RNA sequencing algorithms and FISH in diagnosing round cell sarcomas with CIC gene rearrangements.
|
28233365 |
2017 |
|
Malignant neoplasm of soft tissue
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We recognized the tumor as a genetically distinct variant of CIC-rearranged sarcomas with a novel NUTM2A-CIC fusion.
|
28188754 |
2017 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
The CIC-DUX4 sarcoma is a subset of the undifferentiated small round cell sarcoma family, presently recognized as a new clinicopathological entity.
|
27919577 |
2017 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
This case report describes an additional case of <i>CIC-DUX4</i> sarcoma with a novel fusion breakpoint, and demonstrates the value of this next-generation sequencing-based anchored multiplex PCR technique (Archer FusionPlex Sarcoma Panel) in both diagnosis for patient care and in identification of a novel fusion breakpoint in this tumour type.
|
28137728 |
2017 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
No PAX7 expression was observed in any of 27 cases of CIC-DUX4 sarcoma by immunohistochemistry (0%; 0/27).
|
28643791 |
2017 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
Heterogeneous elements included a myxoid spindle cell component in three BCOR-CCNB3 sarcomas and an epithelioid cell component in two CIC-associated sarcomas (one CIC-DUX4-positive and one CIC-DUX4-negative sarcomas).
|
28197724 |
2017 |
|
Malignant neoplasm of soft tissue
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A recently characterized group of undifferentiated small round cell sarcomas harbours fusions of the genes CIC and DUX4.
|
27790742 |
2017 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
Nonetheless, NKX2-2 may be helpful to distinguish Ewing sarcoma from some histologic mimics including CIC-DUX4 and BCOR-CCNB3 sarcomas.
|
26847175 |
2016 |
|
Malignant neoplasm of soft tissue
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In summary, diffuse moderate-to-strong ETV4 expression is present in most CIC-rearranged sarcomas and unclassified round cell sarcomas.
|
27443513 |
2016 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
A histologic comparison of the CIC-rearranged sarcomas with 20 EWSR1-rearranged Ewing sarcomas showed significantly higher degrees of lobulation, nuclear pleomorphism, the prominence of the nucleoli, spindle cell elements, and myxoid changes in the CIC-rearranged sarcomas.
|
26685084 |
2016 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
The spectrum of ELS is now expanding, and additional gene fusion partners besides DUX4 or CCNB3 have been detected, and the terms CIC or BCOR-rearranged sarcomas have recently been proposed.
|
27306060 |
2016 |