Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Through use of oligonucleotide hybridization, the genomic content and expression of individual MDR-1 alleles were examined in normal tissues, unselected and drug selected cell lines, and malignant lymphomas.
|
9473242 |
1998 |
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The preponderance of evidence suggests that mdr1 expression is relatively low in untreated patients (10% to 20% of lymphomas positive), but increases in patients with recurrent disease (50% to 70% positive).
|
7964963 |
1994 |
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The effect of MDR-1 substrate drugs has not yet been tested as all patients remain in clinical and radiological remission of their lymphoma.
|
9614561 |
1998 |
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
T-25-Adh cells, cell variants derived from S49 mouse lymphoma, were transduced with a retrovirus containing the human MDR1 cDNA.
|
7786606 |
1995 |
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
MDR1 has been the most studied in hematological malignancies, particularly in lymphoma and multiple myeloma (MM), diseases generally considered as overexpressing such mechanisms in relapse.
|
8520514 |
1995 |
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These results indicate that expression of the mdr1 gene is not always detectable in cases of malignant lymphoma resistant to chemotherapy, but the detectable expression of mdr1 gene may predict clinical resistance to chemotherapy.
|
1766262 |
1991 |
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Neither codeinone nor morphine inhibited P-glycoprotein-mediated rhodamine-123 efflux in multidrug resistant mouse T lymphoma L5178 transfected with human MDR 1 gene.
|
12017290 |
2002 |
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MDR1 RNA levels were also increased in some cancers at relapse after chemotherapy, including ALL, ANLL, breast cancer, neuroblastoma, pheochromocytoma, and nodular, poorly differentiated lymphoma.
|
2562856 |
1989 |
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of mdr-1 was also detectable in biopsies from patients at the time of diagnosis of lymphoma.
|
7632959 |
1995 |
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
De novo MDR1 transcript expression was independent of response to therapy in dogs with lymphoma.
|
9568108 |
1998 |
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Mdr1 gene expression in childhood acute lymphoblastic leukemias and lymphomas: a critical evaluation by four techniques.
|
7905944 |
1994 |
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MDR1 mRNA was detected in all reactive LN and in 8 of 10 ML samples examined by reverse transcription polymerase chain reaction (RT-PCR).
|
7961124 |
1994 |
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In non-Hodgkin's lymphoma, less than 20% of untreated de novo lymphomas express MDR-1 compared with approximately 50% after failure of chemotherapy.
|
11755462 |
2002 |
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Constituents of Carpobrotus edulis inhibit P-glycoprotein of MDR1-transfected mouse lymphoma cells.
|
20393003 |
2010 |
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Apoptosis induction and the interaction between epirubicin and the silicon-substituted compounds were studied in human MDR-1 gene-transfected mouse lymphoma and its parent cell line, Colo320/MDR-LRP and sensitive subline Colo205, by means of rhodamine 123 accumulation.
|
15161039 |
2004 |
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The process behind the expression of mdr-1/P-gp and mrp/MRP in human leukemia/lymphoma.
|
19414348 |
2009 |
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
P-glycoprotein is a product of the multidrug resistance (MDR1) gene, which is a major cause of the refractoriness of malignant lymphomas to conventional chemotherapeutic regimens containing anthracycline. l-asparaginase-containing regimens such as SMILE (steroid, methotrexate, ifosfamide, l-asparaginase, and etoposide) are effective for ENKL.
|
23768637 |
2013 |
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
There is an increased incidence of de-novo MDR-1 expression in AIDS-related lymphoma compared with lymphoma in the non-HIV settings.
|
16093797 |
2005 |
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The aim of our study was to establish a lymphoma, cellular system where a de novo acquisition of multidrug resistance is specifically related to overexpression of a transgenic, human MDR1.
|
15725475 |
2005 |
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
When coupled with an anti-CD19 targeted antibody, this formulation was also effective at delivering an MDR1 asODN to a multidrug-resistant human B-lymphoma cell line in vitro, decreasing the activity of P-glycoprotein.
|
10766353 |
2000 |