|
Classical Hodgkin's Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We developed two BV-resistant HL cell line models using a pulsatile approach and observed that resistance to BV is associated with an upregulation of multidrug resistance-1 (MDR1).
|
31811017 |
2020 |
|
Adult Classical Hodgkin Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We developed two BV-resistant HL cell line models using a pulsatile approach and observed that resistance to BV is associated with an upregulation of multidrug resistance-1 (MDR1).
|
31811017 |
2020 |
|
Triple Negative Breast Neoplasms
|
0.010 |
Biomarker
|
disease |
BEFREE |
This yielded robust suppression of the miR-34a target genes CCND-1, Notch-1, Bcl-2, Survivin, and MDR-1, which reduced TNBC cell proliferation and induced cell cycle arrest.
|
31742868 |
2020 |
|
Triple-Negative Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
This yielded robust suppression of the miR-34a target genes CCND-1, Notch-1, Bcl-2, Survivin, and MDR-1, which reduced TNBC cell proliferation and induced cell cycle arrest.
|
31742868 |
2020 |
|
Agenesis of corpus callosum
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MDR1 and P-gp expression were positively correlated in ACC (P<0.0001, ρ = 0.723).
|
30650062 |
2019 |
|
Adrenal Cortical Adenoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MDR1 mRNA and P-gp protein expression were lower in ACCs compared to adrenocortical adenomas (P<0.0001; P<0.01, respectively).
|
30650062 |
2019 |
|
Aplasia Cutis Congenita
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MDR1 and P-gp expression were positively correlated in ACC (P<0.0001, ρ = 0.723).
|
30650062 |
2019 |
|
MOHR-TRANEBJAERG SYNDROME
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study aimed to investigate the role of long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) and multidrug resistance-1 (MDR1) in tumor tissue samples and the chemoresistant human NSCLC cell lines, H460/DDP and A549/DDP, and in a murine A549/DDP tumor xenograft.
|
31659146 |
2019 |
|
Latent Tuberculosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We discovered that M. tuberculosis infection increases the expression of macrophage MDR1 to extrude various chemical substances, including tuberculosis drugs, resulting in enhanced survival of intracellular M. tuberculosis.
|
31412123 |
2019 |
|
Angina Pectoris
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Studies indicate that there is an increased serum concentration of amlodipine (a calcium channel blocker used to treat hypertension and angina) in patients having mutant multidrug resistance 1 (MDR1) gene.
|
28656587 |
2018 |
|
Hepatitis C
|
0.010 |
Biomarker
|
disease |
BEFREE |
With aforementioned results, determination of different forms of SNPs in MDR1 gene should be considered as a predictor in the treatment of all chronic HCV patients.
|
29155127 |
2018 |
|
Hypertensive disease
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Studies indicate that there is an increased serum concentration of amlodipine (a calcium channel blocker used to treat hypertension and angina) in patients having mutant multidrug resistance 1 (MDR1) gene.
|
28656587 |
2018 |
|
Ichthyosis, X-Linked
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that a significant mRNA level of MDR1 gene was intrinsically present in STS before exposure to chemotherapeutic drugs, suggesting that MDR1 may be important contributors of innate chemoresistance of this tumor type.
|
29689707 |
2018 |
|
Hypocholesterolemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Cholesterol depletion by methyl beta cyclodextrin (MβCD) inhibited malignant ascites-induced chemoresistance to CDDP and upregulation of MDR1 and LXRɑ/β.
|
30526541 |
2018 |
|
Androgenetic Alopecia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The effect of ABR on the expression levels of P-glycoprotein (P-gp) and MDR1 mRNA in the synovial tissues of knee joints in AGA rats was examined by Western blot and RT-qPCR assay, respectively.
|
29679725 |
2018 |
|
Liver Failure, Acute
|
0.010 |
Biomarker
|
disease |
BEFREE |
MDCK-MDR1 and HCMEC/D3 cells were used to document the effects of the abnormally altered components in serum of ALF mice on the function and expression of P-GP.
|
29559914 |
2018 |
|
Erythroblastosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The intracellular multidrug resistance 1 (MDR1) mRNA and upstream erythroblastosis virus E26 oncogene homolog 1 (ETS1) mRNA can be silenced by MBs, which can effectively inhibit the expression of P-gp and further prevent the efflux of Dox and reverse MDR.
|
29663807 |
2018 |
|
Hepatitis C, Chronic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
MDR1 gene C3435T polymorphism in chronic hepatitis C patients.
|
29155127 |
2018 |
|
Candidiasis, Vulvovaginal
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to investigate the association between Mrr1, adenylyl cyclase-associated protein 1 (Cap1) and multi-drug resistance gene 1 (MDR1), and to assess the mutations in Mrr1 and Cap1 in azole-resistant <i>Candida albicans</i> strains.The study isolated 68 <i>C. albicans</i> strains from patients with vulvovaginal candidiasis.
|
29434708 |
2018 |
|
Steroid Sulfatase Deficiency Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that a significant mRNA level of MDR1 gene was intrinsically present in STS before exposure to chemotherapeutic drugs, suggesting that MDR1 may be important contributors of innate chemoresistance of this tumor type.
|
29689707 |
2018 |
|
Amyloidosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The expulsion of Aβ via the blood-brain barrier is mediated by specialized transport proteins such as P-glycoprotein (P-gp, ABCB1/MDR1).
|
27915995 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
In case of CYP46A1 gene, CC (p < 0.001) and CT (p = 0.001) genotypes and C allele (p < 0.001) were found to be a positive risk factor and TT genotype (p < 0.001) and T allele (p < 0.001) as negative risk factor for T2DM whereas, no association of MDR1 gene was found with T2DM (P values of all genotypes and alleles were greater than 0.001).
|
28206854 |
2017 |
|
Hepatolenticular Degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data add to the versatile functions of MDR1 in the hepatocyte and may have an impact on the treatment of copper-related diseases, prominently WD.
|
28805879 |
2017 |
|
Ileitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Blocking ileal CBA reabsorption in transferred Rag1<sup>-/-</sup> mice restored Mdr1-deficient Teff cell homeostasis and attenuated ileitis.
|
29262351 |
2017 |
|
T-Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Effect of compound 1 on the reversion of multidrug resistant (MDR) mediated by Pglycoprotein (P-gp) against cancer cells was evaluated with a rhodamine-123 exclusion screening test on human mdr1 gene transfected mouse gene transfected L5178 and L5178Y mouse T-cell lymphoma.
|
28606042 |
2017 |