Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
SMYD2-OE promotes oxaliplatin resistance in colon cancer through MDR1/P-glycoprotein via MEK/ERK/AP1 pathway.
|
31040701 |
2019 |
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we found that protein expression of ABCB1 (ATP Binding Cassette Subfamily B Member 1) / MDR1 (multidrug resistance 1) was diminished in the intestinal mucosa of patients with active UC with or without CAC, but not in non-UC patients with sporadic colon cancer.
|
28686677 |
2017 |
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of HIF-1α and MDR1/P-gp can be used as a predictive marker for chemotherapy resistance in colon cancer.
|
24901645 |
2014 |
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Sinomenine sensitizes multidrug-resistant colon cancer cells (Caco-2) to doxorubicin by downregulation of MDR-1 expression.
|
24901713 |
2014 |
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we report that the human colonic cancer cell line HT29 (MDR-1 negative) is more malignant than its MDR-1 overexpressing variant (HT29 MDR-1 positive).
|
22154301 |
2012 |
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Inhibition of COX-2 in colon cancer modulates tumor growth and MDR-1 expression to enhance tumor regression in therapy-refractory cancers in vivo.
|
22904679 |
2012 |
Malignant tumor of colon
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study was to investigate the therapeutic potential of ¹³¹I added to doxorubicin therapy in multidrug resistance (MDR) mouse colon cancer coexpressing the MDR1 small hairpin RNA (shRNA) and human sodium iodide symporter (hNIS) gene in a single gene construct and to visualize the antitumor effects using molecular nuclear imaging.
|
21204761 |
2010 |
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Enhanced anti-tumor effects of combined MDR1 RNA interference and human sodium/iodide symporter (NIS) radioiodine gene therapy using an adenoviral system in a colon cancer model.
|
20186172 |
2010 |
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The reversal effect of multidrug resistance (MDR1) gene expression by adenoviral vector-mediated MDR1 ribonucleic acid interference was assessed in a human colon cancer animal model using bioluminescent imaging with Renilla luciferase (Rluc) gene and coelenterazine, a substrate for Rluc or MDR1 gene expression.
|
21084030 |
2010 |
Malignant tumor of colon
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present study suggests that MDR1 2677G>T and 3435C>T polymorphism is not a risk factor for sporadic colon cancer among Bulgarians and that somatic mutation at these sites is not involved in the genesis of colon tumors.
|
17674045 |
2008 |
Malignant tumor of colon
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MDR1 C3435T polymorphism influences the development of colon cancer and adult acute myeloid leukemia by the association with transporting carcinogen.
|
18644389 |
2008 |
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Real-time RT-PCR analysis revealed that MDR1 mRNA was not detected in the 10 gastric cancer cell lines but variable MDR1 mRNA levels in 7 of 9 colon cancer cell lines except the SNU-C5 and HT-29 cells.
|
18673531 |
2008 |
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The endocrine disrupting chemical, diethylhexyl phthalate, activates MDR1 gene expression in human colon cancer LS174T cells.
|
17003290 |
2006 |
Malignant tumor of colon
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic testing for C3435T MDR1 gene polymorphism may be a suitable test to evaluate the risk for colon cancer in patients under 50 years of age.
|
15912392 |
2005 |
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of mdr1 gene corresponds to the sensitivity of colon cancer to anti-tumor drugs in vivo.
|
15742416 |
2005 |
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We examined the effects of suppressing multidrug resistance-associated protein (MRP) and multidrug resistance 1 (MDR1) gene expression in HCT-8DDP human colon cancer cell lines, which showed both cisplatin and multidrug resistance.
|
12370750 |
2002 |
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
There may be a therapeutic window for taxanes in colon cancer by optimizing pharmacokinetics and modulating MDR-1 and bcl-2 resistance factors.
|
11052631 |
2000 |
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
In order to selectively reverse MDR in malignant tissue without disrupting the function of normal colonocytes, a retroviral vector (pCEAMR) containing anti-mdr1 ribozyme coupled to the carcino-embryonic-antigen (CEA) promoter was constructed and introduced into resistant colon-cancer cells (SW1116R) that produce CEA and into control resistant cells (HeLaK) that do not produce CEA.
|
10399951 |
1999 |
Malignant tumor of colon
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In an adriamycin-selected resistant colon cancer line (S48-3s/Adr), WCP4/WCP7 revealed t(4;7)(q31;q21) and BAC-derived probes demonstrated that the breakpoint lay between MDR1 and sequences 500-1000 KB telomeric to it.
|
9713996 |
1998 |
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The clinical significance of expression of the MDR1 gene product P-glycoprotein (P-gp) in relation to the intrinsic drug resistance and progression of human colon cancer is largely unknown.
|
7954255 |
1994 |
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We investigated the mechanism of sodium butyrate (NaB)-mediated induction of mdr1 mRNA in parental (wild type) and multidrug-resistant (Ad1000) SW620 colon cancer cell lines.
|
7908296 |
1994 |
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
By contrast, some levels of MDR1 mRNA expression were found in two colon cancer cell lines, indicating doxorubicin resistance.
|
1735085 |
1992 |
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Reversal of drug resistance in a human colon cancer xenograft expressing MDR1 complementary DNA by in vivo administration of MRK-16 monoclonal antibody.
|
1681110 |
1991 |