PLCB1, phospholipase C beta 1, 23236

N. diseases: 107; N. variants: 35
Disease: Major Depressive Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.410 GeneticVariation disease GWASCAT A genome-wide association study of suicidal behavior. 26079190 2015
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.410 Biomarker disease BEFREE Literature data suggested that phosphoinositides (PI) signal transduction pathway and related molecules such as the Phosphoinositide-specific Phospholipase C (PI-PLC) enzymes, might be involved in the pathophysiology of mood disorders, including major depression. 21880371 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.410 Biomarker disease PSYGENET By using interphase fluorescent in situ hybridization methodology, we analyzed PLCB1 gene, which codifies for the PI-PLC β1 enzyme, in paraffin embedded samples of orbito-frontal cortex of 15 patients affected with major depression and in 15 normal controls. 21880371 2012