Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).
|
20228798 |
2010 |
Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).
|
20228798 |
2010 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
|
22190364 |
2011 |
C-reactive protein measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Group IIA Secretory Phospholipase A2, Vascular Inflammation, and Incident Cardiovascular Disease.
|
31070471 |
2019 |
Malignant neoplasm of breast
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here, we demonstrate that in vivo deletion of OTUD3 indeed promotes breast cancer development in mice, but by contrast, it slows down Kras<sup>G12D</sup>-driven lung adenocarcinoma (ADC) initiation and progression and markedly increases survival in mice.
|
31266968 |
2019 |
Malignant tumor of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, OTUD3 silence promoted proliferation and motility and decreased apoptosis for HCT116 cells and restored partly miR-32-mediated cell proliferation, migration, and antiapoptosis for colon cancer.
|
31338872 |
2019 |
Non-Small Cell Lung Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results indicated that high mRNA expression levels of OTUD1, OTUD3, OTUD4 and putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 were associated with improved prognosis in all NSCLC and adenocarcinoma, but not in squamous cell carcinoma.
|
31612050 |
2019 |
Adenocarcinoma of lung (disorder)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here, we demonstrate that in vivo deletion of OTUD3 indeed promotes breast cancer development in mice, but by contrast, it slows down Kras<sup>G12D</sup>-driven lung adenocarcinoma (ADC) initiation and progression and markedly increases survival in mice.
|
31266968 |
2019 |
Malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, our results reveal a previously unappreciated pro-oncogenic role of OTUD3 in lung cancer and indicate that deubiquitylases could elicit tumor-suppressing or tumor-promoting activities in a cell- and tissue-dependent context.
|
31266968 |
2019 |
Carcinogenesis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Knockdown of OTUD3 results in a decrease in the level of GRP78 protein, suppression of cell growth and migration, and tumorigenesis in lung cancer.
|
31266968 |
2019 |
Breast Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here, we demonstrate that in vivo deletion of OTUD3 indeed promotes breast cancer development in mice, but by contrast, it slows down Kras<sup>G12D</sup>-driven lung adenocarcinoma (ADC) initiation and progression and markedly increases survival in mice.
|
31266968 |
2019 |
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, our results reveal a previously unappreciated pro-oncogenic role of OTUD3 in lung cancer and indicate that deubiquitylases could elicit tumor-suppressing or tumor-promoting activities in a cell- and tissue-dependent context.
|
31266968 |
2019 |
Colon Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, OTUD3 silence promoted proliferation and motility and decreased apoptosis for HCT116 cells and restored partly miR-32-mediated cell proliferation, migration, and antiapoptosis for colon cancer.
|
31338872 |
2019 |
Primary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, our results reveal a previously unappreciated pro-oncogenic role of OTUD3 in lung cancer and indicate that deubiquitylases could elicit tumor-suppressing or tumor-promoting activities in a cell- and tissue-dependent context.
|
31266968 |
2019 |