Essential Tremor
|
0.100 |
Biomarker
|
disease |
BEFREE |
OBJECTIVEPosterior subthalamic area (PSA) deep brain stimulation (DBS) targeting the zona incerta (ZI) is an emerging treatment for tremor syndromes, including Parkinson's disease (PD) and essential tremor (ET).
|
30875687 |
2019 |
Essential Tremor
|
0.100 |
Biomarker
|
disease |
BEFREE |
High frequency Deep brain stimulation (DBS) targeting motor thalamus is an effective therapy for essential tremor (ET).
|
30827864 |
2019 |
Essential Tremor
|
0.100 |
Biomarker
|
disease |
BEFREE |
As the motor thalamus is the most popular DBS target for ET, and it is known that the thalamic nucleus plays a key role in relaying information about the external environment to the cerebral cortex, it is important to investigate mechanisms of thalamic DBS in the context of the cerebello-thalamo-cortical neuronal network.
|
31680866 |
2019 |
Essential Tremor
|
0.100 |
Biomarker
|
disease |
BEFREE |
DBS is initially used for treatment of essential tremor and Parkinson's disease in adults.
|
29797064 |
2018 |
Essential Tremor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We recruited 8 patients with essential tremor in a stable postoperative condition (>3 months after electrode implantation of deep brain stimulation [DBS] electrodes) with segmented contacts implanted in the VIM.
|
30045955 |
2018 |
Essential Tremor
|
0.100 |
Biomarker
|
disease |
BEFREE |
This finding further supports ZI over VIM as the principal DBS target in essential tremor.
|
29196249 |
2018 |
Essential Tremor
|
0.100 |
Biomarker
|
disease |
BEFREE |
To evaluate whether unilateral DBS targeting the caudal zona incerta (cZi) may be sufficient to alleviate voice tremor in patients with essential tremor, or whether bilateral stimulation is needed.
|
29975951 |
2018 |
Essential Tremor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we tested this theory by investigating modulation of spike rates and patterns in non-human primate motor thalamus while stimulating the cerebellar-receiving area of motor thalamus, the primary DBS target for treating Essential Tremor.
|
29391468 |
2018 |
Essential Tremor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, we demonstrate the value of such a conversion using the DBS target for essential tremor as an example, relating the site of the active DBS contact to different MNI atlases as well as anatomical and functional connectomes in MNI space.
|
28163141 |
2017 |
Essential Tremor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Literature searches of magnetic resonance-guided focused ultrasound thalamotomy, DBS, and stereotactic radiosurgery for essential tremor were performed.
|
28370272 |
2017 |
Essential Tremor
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the thalamotomy group, the risk was higher in Parkinson's patients, whereas in the DBS group it was higher in patients with essential tremor.
|
28124434 |
2017 |
Essential Tremor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Continuous high-frequency DBS is an established treatment for essential tremor and Parkinson's disease.
|
28597557 |
2017 |