Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0270736
Disease: Essential Tremor
Essential Tremor
0.100 Biomarker disease BEFREE OBJECTIVEPosterior subthalamic area (PSA) deep brain stimulation (DBS) targeting the zona incerta (ZI) is an emerging treatment for tremor syndromes, including Parkinson's disease (PD) and essential tremor (ET). 30875687 2019
CUI: C0270736
Disease: Essential Tremor
Essential Tremor
0.100 Biomarker disease BEFREE High frequency Deep brain stimulation (DBS) targeting motor thalamus is an effective therapy for essential tremor (ET). 30827864 2019
CUI: C0270736
Disease: Essential Tremor
Essential Tremor
0.100 Biomarker disease BEFREE As the motor thalamus is the most popular DBS target for ET, and it is known that the thalamic nucleus plays a key role in relaying information about the external environment to the cerebral cortex, it is important to investigate mechanisms of thalamic DBS in the context of the cerebello-thalamo-cortical neuronal network. 31680866 2019
CUI: C0270736
Disease: Essential Tremor
Essential Tremor
0.100 Biomarker disease BEFREE DBS is initially used for treatment of essential tremor and Parkinson's disease in adults. 29797064 2018
CUI: C0270736
Disease: Essential Tremor
Essential Tremor
0.100 GeneticVariation disease BEFREE We recruited 8 patients with essential tremor in a stable postoperative condition (>3 months after electrode implantation of deep brain stimulation [DBS] electrodes) with segmented contacts implanted in the VIM. 30045955 2018
CUI: C0270736
Disease: Essential Tremor
Essential Tremor
0.100 Biomarker disease BEFREE This finding further supports ZI over VIM as the principal DBS target in essential tremor. 29196249 2018
CUI: C0270736
Disease: Essential Tremor
Essential Tremor
0.100 Biomarker disease BEFREE To evaluate whether unilateral DBS targeting the caudal zona incerta (cZi) may be sufficient to alleviate voice tremor in patients with essential tremor, or whether bilateral stimulation is needed. 29975951 2018
CUI: C0270736
Disease: Essential Tremor
Essential Tremor
0.100 Biomarker disease BEFREE Here, we tested this theory by investigating modulation of spike rates and patterns in non-human primate motor thalamus while stimulating the cerebellar-receiving area of motor thalamus, the primary DBS target for treating Essential Tremor. 29391468 2018
CUI: C0270736
Disease: Essential Tremor
Essential Tremor
0.100 Biomarker disease BEFREE Finally, we demonstrate the value of such a conversion using the DBS target for essential tremor as an example, relating the site of the active DBS contact to different MNI atlases as well as anatomical and functional connectomes in MNI space. 28163141 2017
CUI: C0270736
Disease: Essential Tremor
Essential Tremor
0.100 Biomarker disease BEFREE Literature searches of magnetic resonance-guided focused ultrasound thalamotomy, DBS, and stereotactic radiosurgery for essential tremor were performed. 28370272 2017
CUI: C0270736
Disease: Essential Tremor
Essential Tremor
0.100 Biomarker disease BEFREE In the thalamotomy group, the risk was higher in Parkinson's patients, whereas in the DBS group it was higher in patients with essential tremor. 28124434 2017
CUI: C0270736
Disease: Essential Tremor
Essential Tremor
0.100 Biomarker disease BEFREE Continuous high-frequency DBS is an established treatment for essential tremor and Parkinson's disease. 28597557 2017