Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
DBS is a surgical method of choice for various movement disorders, especially for Parkinson's disease (PD).
|
28320164 |
2017 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
DBS is initially used for treatment of essential tremor and Parkinson's disease in adults.
|
29797064 |
2018 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Application of a newly developed semiquantitative questionnaire (FST-questionnaire [Fragebogen zur Veränderung der Selbstwahrnehmung unter tiefer Hirnstimulation]: Questionnaire regarding changes in self-perception while treated with DBS) to systematically assess changes in self-perception in a single-center, cross-sectional pilot-study at the University Hospital Freiburg, Germany on 50 patients (44% male; age 50 years [range: 27-73 years]), undergoing neurostimulation (DBS, iVNS, tVNS, or eTNS) to treat Parkinson's disease or epilepsy.
|
30500485 |
2019 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Clinical trials have established subthalamic deep-brain-stimulation (STN-DBS) as a highly effective treatment for motor symptoms of Parkinson disease (PD), but in clinical practice outcomes are variable.
|
30839077 |
2019 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Continuous high-frequency DBS is an established treatment for essential tremor and Parkinson's disease.
|
28597557 |
2017 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Education level is associated with DT-related gait changes in PD one year post-DBS.
|
31621623 |
2019 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Evidence was divided into four categories: medication used in PD management, imaging studies, genetic analysis and subthalamic deep brain stimulation (STN-DBS).
|
22713408 |
2013 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we investigate whether the ventroanterior (VA) and ventrolateral (VL) motor nuclei of the thalamus can serve as novel and effective DBS targets for PD.
|
30890329 |
2019 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
High-contrast hybrid images can be used for precisely directed DBS targeting, e.g., GPi DBS for the treatment of advanced Parkinson's disease.
|
31604332 |
2019 |
Parkinson Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, little is known about the initial effects of STN-DBS on nonmotor domains.Our objective was to elucidate the initial effects of STN-DBS on non-motor and motor symptoms in PD patients in a 4-month follow-up.This open prospective study followed 24 patients with PD who underwent STN-DBS.
|
29384860 |
2018 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present review, we summarized previous investigations focusing on STN-DBS influence on recognition of facial emotional expressions in patients suffering from PD.
|
31849760 |
2019 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Knowledge about the impact of DBS on specific symptoms in PD and about DBS targets was limited in both groups.
|
28434004 |
2017 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Measures of impulsivity in Parkinson's disease decrease after DBS in the setting of stable dopamine therapy.
|
28827010 |
2017 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nine patients with Parkinson's disease underwent DBS implantation in the subthalamic nucleus.
|
31216311 |
2019 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nonetheless, we were able to discern subtle but distinct effects of PD and STN DBS in the emotional responses.
|
29936120 |
2018 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
OBJECTIVEPosterior subthalamic area (PSA) deep brain stimulation (DBS) targeting the zona incerta (ZI) is an emerging treatment for tremor syndromes, including Parkinson's disease (PD) and essential tremor (ET).
|
30875687 |
2019 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
On an individual level, participants with PD exhibited heterogeneous changes with DBS stimulation.
|
29032347 |
2017 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data suggest that the effects of STN-DBS in PD directly depend on frontal lobe grey matter integrity.
|
28262813 |
2017 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Selection of the best deep brain stimulation (DBS) target-subthalamic nucleus (STN) or globus pallidus interna (GPi)-for treatment of motor complications in Parkinson disease remains a matter of debate.
|
29356826 |
2018 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Standardised Neuropsychological Assessment for the Selection of Patients Undergoing DBS for Parkinson's Disease.
|
29971141 |
2018 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Stimulation challenge test after STN DBS improves satisfaction in Parkinson's disease patients.
|
31665685 |
2019 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Studies of alternative DBS targets for PD are ongoing, the majority of which have shown some clinical benefit; however, more carefully designed and controlled studies are needed.
|
28761773 |
2017 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to evaluate the effect of DBS on olfactory function in PD, as well as to explore the correlation between these changes and changes in motor symptoms and brain metabolism.
|
29548954 |
2018 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of this study was first to identify the influence of acute manipulation of STN-DBS in PD on the number and time pattern of word generation on different verbal fluency (VF) tasks, phonemic, switching, and cued switching, and second to determine whether cueing improved VF and if cueing effects interacted with STN-DBS effects.
|
31687126 |
2019 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The effects of deep brain stimulation of the subthalamic nucleus (DBS-STN) and L-dopa (LD) on cortical activity in Parkinson's disease (PD) are poorly understood.
|
27771287 |
2017 |