SLC9A8, solute carrier family 9 member A8, 23315

N. diseases: 16; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0338630
Disease: Senile Paranoid Dementia
Senile Paranoid Dementia 		0.300 Biomarker disease CTD_human Decreased NHE8 isoform expression and defective acidification in proximal convoluted tubules of senile rats. 19234771 2009
CUI: C0497327
Disease: Dementia
Dementia 		0.300 Biomarker disease CTD_human Decreased NHE8 isoform expression and defective acidification in proximal convoluted tubules of senile rats. 19234771 2009
CUI: C0751071
Disease: Familial Dementia
Familial Dementia 		0.300 Biomarker disease CTD_human Decreased NHE8 isoform expression and defective acidification in proximal convoluted tubules of senile rats. 19234771 2009
CUI: C0008313
Disease: Cholangitis, Sclerosing
Cholangitis, Sclerosing 		0.100 GeneticVariation disease GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.100 GeneticVariation disease GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.100 GeneticVariation disease GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.100 GeneticVariation disease GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis 		0.100 GeneticVariation disease GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 GeneticVariation disease GWASCAT Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. 24076602 2013
CUI: C0011991
Disease: Diarrhea
Diarrhea 		0.020 AlteredExpression phenotype BEFREE Up-regulation of NHE8 improved diarrhea symptom and mucosal damage induced by CR. 29719449 2018
CUI: C0011991
Disease: Diarrhea
Diarrhea 		0.020 AlteredExpression phenotype BEFREE In conclusion, our studies suggest that TNF-alpha decreases NHE8 expression in inflammation induced by TNBS and LPS, which may contribute to the diarrhea associated with inflammation. 19109523 2009
CUI: C4023106
Disease: Obstructive azoospermia
Obstructive azoospermia 		0.010 GeneticVariation disease BEFREE Instead, deficiency in solute carrier family 9 sodium/hydrogen exchanger isoform 3 (SLC9A3) may play a role by generating obstructive azoospermia and degraded epithelial structure in the reproductive tract. 30956978 2019
CUI: C0149871
Disease: Deep Vein Thrombosis
Deep Vein Thrombosis 		0.010 AlteredExpression disease BEFREE Thus, given the environmental condition the differential expression of hypoxia-responsive genes (angiogenin, ribonuclease, RNase A family, 5; early growth response 1; lamin A; matrix metallopeptidase 14 [membrane-inserted]; neurofibromin 1; PDZ and LIM domain 1; procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1; solute carrier family 6 [neurotransmitter transporter, serotonin], member 4; solute carrier family 9 [sodium/hydrogen exchanger], member 1; and TEK tyrosine kinase, endothelial) in HA-DVT could be a determining factor to understand the pathophysiology of DVT at HA. 29864786 2018
CUI: C0277524
Disease: Infectious colitis
Infectious colitis 		0.010 Biomarker disease BEFREE This study further explored whether NHE8 participates in the pathological processes of infectious colitis and the effects of SST on intestinal NHE8 expression in the setting of infectious colitis. 29719449 2018
CUI: C0021364
Disease: Male infertility
Male infertility 		0.010 Biomarker phenotype BEFREE Loss of the Na<sup>+</sup>/H<sup>+</sup> exchanger NHE8 causes male infertility in mice by disrupting acrosome formation. 28476888 2017
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.010 Biomarker disease BEFREE This study has identified several genes of interest, such as HLA-C, SLC16A3, SLC9A8, SLC12A1 and SLC7A2, that require verification of their roles as susceptibility genes for diabetic nephropathy in ethnic Malays with type 2 DM. 21360476 2012
CUI: C0267663
Disease: Congenital secretory diarrhea, sodium type (disorder)
Congenital secretory diarrhea, sodium type (disorder) 		0.010 Biomarker disease BEFREE Nucleotide sequence of the Na+/H+ exchanger-8 in patients with congenital sodium diarrhea. 21666503 2011