Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.330 GeneticVariation disease BEFREE Never having been married and smaller CGG repeat length were associated with increased likelihood of MDD while increased children with FXS in the family and greater child problem behaviors were associated with increased likelihood of an anxiety disorder in the FMR 1 premutation group. 18553360 2009
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.330 Biomarker disease PSYGENET Major depression in females with the FMR1 premutation may not be characterized as an episodically chronic recurrent disorder as it is in community samples and may have a genetic basis given the relationship with CGG repeat length and lack of association with all child and most demographic factors. 18553360 2009
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.330 Biomarker disease PSYGENET In the current study, we have expanded our previous studies to examine the protein and mRNA expression of two novel GABAA receptors, theta (GABRθ) and rho 2 (GABRρ2) as well as FMRP, and metabotropic glutamate receptor 5 (mGluR5) in lateral cerebella of subjects with schizophrenia, bipolar disorder, major depression and healthy controls, and in superior frontal cortex (Brodmann Area 9 (BA9)) of subjects with schizophrenia, bipolar disorder and healthy controls. 23778581 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.330 AlteredExpression disease BEFREE Reduced FMRP expression has been identified in subjects with autism, schizophrenia, bipolar disorder, and major depression who do not carry the mutation for FMR1. 25956630 2015
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.330 GeneticVariation disease BEFREE In women with the FMR1 premutation, elevated optimism may reduce the occurrence or severity of MDD and anxiety disorders. 28895261 2017