|
Diminished ovarian reserve
|
0.100 |
Biomarker
|
disease |
BEFREE |
The association between the FMR1 premutation (50-200 CGG repeats) and the premature ovarian failure (POF) suggests that epigenetic disorders of FMR1 can act as a risk factor for the DOR as well.
|
29308622 |
2018 |
|
Diminished ovarian reserve
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Distribution of the FMR1 gene in females by race/ethnicity: women with diminished ovarian reserve versus women with normal fertility (SWAN study).
|
27816231 |
2017 |
|
Diminished ovarian reserve
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Based on the current evidence, we concluded that intermediate-sized FMR1 CGG repeat alleles should not be considered as a high-risk factor for POF and DOR.
|
27876427 |
2017 |
|
Diminished ovarian reserve
|
0.100 |
Biomarker
|
disease |
BEFREE |
Correlations were performed between normal-range FMR1 length and baseline serum anti-Müllerian hormone (AMH), cycle day 3 follicle stimulating hormone (FSH), ovarian volumes (OV), antral follicle counts (AFC), and incidence of diminished ovarian reserve (DOR), while controlling for the effect of age.
|
27189053 |
2016 |
|
Diminished ovarian reserve
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This large data set demonstrated that a high normal number of CGG repeats (35-54 repeats) on the FMR1 gene was not significantly correlated with DOR.
|
26345686 |
2015 |
|
Diminished ovarian reserve
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Twenty-one articles identified genes associated with DOR: one gene mutation (FMR1), three polymorphisms (GDF9, FSHR, and ESR1), and seven genes differentially expressed between women with DOR and controls (AMH, LHCGR, IGF1, IGF2, IGF1R, IGF2R and GREM1).
|
24840722 |
2014 |
|
Diminished ovarian reserve
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Attitudes towards potentially carrying the FMR1 premutation: before vs after testing of non-carrier females with diminished ovarian reserve.
|
24788194 |
2014 |
|
Diminished ovarian reserve
|
0.100 |
Biomarker
|
disease |
BEFREE |
AMH in women with diminished ovarian reserve: potential differences by FMR1 CGG repeat level.
|
24938362 |
2014 |
|
Diminished ovarian reserve
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In a prospective cohort study we investigated 213 women with DOR, stratified for age (≤ 38 or >38 years) and ovarian FMR1 genotypes/sub-genotypes.
|
23212832 |
2013 |
|
Diminished ovarian reserve
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These observations suggest that the effectiveness of androgen supplementation in women with POA varies based on FMR1 genotypes, and defines androgen deficiency as a subset of diminished ovarian reserve.
|
22811313 |
2012 |
|
Diminished ovarian reserve
|
0.100 |
Biomarker
|
disease |
BEFREE |
Elevated prevalence of 35-44 FMR1 trinucleotide repeats in women with diminished ovarian reserve.
|
22581803 |
2012 |
|
Diminished ovarian reserve
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The chromosomal abnormality observed in this family supports the presence of a DOR susceptibility locus in the distal Xq region and targets the POF1 region for further investigation.
|
21859812 |
2011 |
|
Diminished ovarian reserve
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The number of CGG repeats on the FMR1 gene appears to represent a potentially useful new test in diagnosing risk toward diminished ovarian reserve and female infertility.
|
19642041 |
2009 |
|
Diminished ovarian reserve
|
0.100 |
Biomarker
|
disease |
BEFREE |
This was a cross-sectional survey of women with elevated follicle stimulating hormone levels with (premature ovarian failure or early menopause [POF/EM], n = 20) or without (diminished ovarian reserve [DOR], n = 20) amenorrhea.Seventy-five percent participated.
|
16522406 |
2006 |