Diabetic Nephropathy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In addition, intravenous administration of KLPPR resulted in excellent kidney-targeted distribution and low urinary excretion in mice with streptozocin-induced diabetic nephropathy (DN), lowered the parameters of urea nitrogen, serum creatinine and kidney index, as well as facilitated the recovery of renal physiological function in improving the levels of urinary creatinine and the creatinine clearance rate by suppressing secretion and accumulation of fibronectin and TGF-β1.
|
31534545 |
2019 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
MiR-192 causes degradation of TGF-β1 and FN through targeting Egr1 and affects the progression of TIF and even DN.
|
30024615 |
2018 |
Diabetic Nephropathy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Increased ColIV and FN levels may be partially responsible for the development of DN.
|
30233688 |
2018 |
Diabetic Nephropathy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In view of the regulation of inflammation and fibrosis by myocardin-related transcription factor A (MRTF-A), we are highly concerned whether CK2α promotes AGEs-induced expressions of FN and ICAM-1 in glomerular mesangial cells via activation of MRTF-A, thus affecting the pathogenesis of DN.
|
29223351 |
2018 |
Diabetic Nephropathy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The expression of FN, Col‑I, SCF and c‑kit mRNA and protein was upregulated in the tubulointerstitium of DKD model rats compared with the normal control rats, and tranilast inhibited the upregulated expression of these markers.
|
29568954 |
2018 |
Diabetic Nephropathy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Sphingosine kinase 1 mediates AGEs-induced fibronectin upregulation in diabetic nephropathy.
|
29108256 |
2017 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
Apigenin ameliorates streptozotocin-induced diabetic nephropathy in rats via MAPK-NF-κB-TNF-α and TGF-β1-MAPK-fibronectin pathways.
|
28566504 |
2017 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, the exact role of fibronectin in the pathogenesis of diabetic nephropathy remains unknown.
|
28159318 |
2017 |
Diabetic Nephropathy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Moreover, ECH inhibited the TGF-β1/Smads signaling pathway, downregulated fibronectin (FN), collagen IV, and alpha-smooth muscle actin (α-SMA) levels, and upregulated E-cadherin level in the db/db mice model of DN.
|
29033543 |
2017 |
Diabetic Nephropathy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Sp1 siRNA treatment reduced fibronectin expression, an extracellular matrix protein that is increased in diabetic nephropathy and tubulopathy.
|
28208054 |
2017 |
Diabetic Nephropathy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
When mice that exhibited genetic type II diabetes developed DN, ASncmtRNA-2 expression was significantly increased (P=0.017) and was positively correlated with pro-fibrotic factor transforming growth factor β1 (TGFβ1) expression and its downstream gene, fibronectin.
|
28352334 |
2017 |
Diabetic Nephropathy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
By determining the expression of transforming growth factor-β1 (TGF-β1), connective tissue growth factor (CTGF), collagen type IV (ColIV) and fibronectin (FN) levels in high glucose-cultured glomerular mesangial cells (MCs), the present study aimed to assess the anti-proliferative and anti-fibrotic effects of SIT on the therapeutic potential for the prevention of DN and its mechanism.
|
29042993 |
2017 |
Diabetic Nephropathy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Then, we analyzed the effects of Fn Msp iv polymorphism on the clinicopathologic stages of DN, the result showed that DD genotype showed great effect on the occurrence of early-onset DN (OR=7.500, 95% CI=1.691-33.272).
|
26045844 |
2015 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
CTD_human |
The effect of resveratrol on the expression of AdipoR1 in kidneys of diabetic nephropathy.
|
24413998 |
2014 |
Diabetic Nephropathy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The urinary mRNA levels of α-SMA, fibronectin and MMP-9 were significantly higher in the DN group compared with controls (P < 0·05), and mRNA levels increased with DN progression.
|
21824169 |
2012 |
Diabetic Nephropathy
|
0.600 |
Therapeutic
|
disease |
RGD |
Diabetes-induced renal injury in rats is attenuated by suramin.
|
22736507 |
2012 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
These findings may help understanding the pathogenesis of proteinuria and glomerular FN deposits in GFND and possibly in more common renal diseases such as diabetic nephropathy, IgA nephropathy, and lupus nephritis.
|
18268355 |
2008 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our in vitro and in vivo findings indicate a role for the MCP-1/CCR2 system in fibronectin deposition in the diabetic glomerulus, providing a new therapeutic target for diabetic nephropathy.
|
17968528 |
2008 |
Diabetic Nephropathy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Suppression of AGEs induced TGF-beta1, CTGF and Fn mRNA overexpression in renal fibroblasts through inhibition of oxidative stress may be a mechanism underlying effect of ginkgo biloba extract in diabetic nephropathy.
|
17531120 |
2007 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
The ASO also reduced expression of genes involved in matrix expansion such as fibronectin and collagen (I and IV) and an inhibitor of matrix degradation, PAI-1, in the renal cortex, contributing to significant reversal of mesangial expansion in both models of DN.
|
17554073 |
2007 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
SGK1-mediated fibronectin formation in diabetic nephropathy.
|
16301823 |
2005 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
These genes included (a) known regulators of mesangial cell activation in diabetic nephropathy (fibronectin, caldesmon, thrombospondin, and plasminogen activator inhibitor-1), (b) novel genes, and (c) known genes whose induction by high glucose has not been reported.
|
10026205 |
1999 |
Diabetic Nephropathy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
A causal relationship between oxidative stress and diabetic nephropathy has been established by observations that (1) lipid peroxides and 8-hydroxydeoxyguanosine, indices of oxidative tissue injury, were increased in the kidneys of diabetic rats with albuminuria; (2) high glucose directly increases oxidative stress in glomerular mesangial cells, a target cell of diabetic nephropathy; (3) oxidative stress induces mRNA expression of TGF-beta1 and fibronectin which are the genes implicated in diabetic glomerular injury, and (4) inhibition of oxidative stress ameliorates all the manifestations associated with diabetic nephropathy.
|
10588367 |
1999 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
Protein and mRNA expression of TGF-beta isoforms, TGF-beta 1, -beta 2 and -beta 3, and deposition of fibronectin containing extra domain A (fibronectin EDA+) and plasminogen activator inhibitor-1 (PAI-1) were studied in human chronic glomerulonephritis and diabetic nephropathy.
|
8821830 |
1996 |