Pulmonary Fibrosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Administration of lentivirus coding mouse P120 sh-RNA into mouse lung tissue dramatically attenuated the expression of P120 in lung tissue and lung fibroblast, suppressed BLM induced increase of TGF-β, alpha smooth muscle actin (α-SMA) and fibronectin (FN) expression, and decreased the deposition of collagen and pulmonary fibrosis.
|
31125560 |
2019 |
Pulmonary Fibrosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we found that BLM-induced lung fibrosis with thickened interstitial lung tissue, including fibronectin and collagen, was correlated with the increased serum concentrations of IL-6 and IL-33 and accompanied by reduced lung function, including FRC (functional residual capacity), C chord (lung compliance), IC (inspiratory capacity), VC (vital capacity), TLC (total lung capacity), and FVC (forced vital capacity) (<i>p</i> < 0.05).
|
31049028 |
2019 |
Pulmonary Fibrosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The administration of SA (IP) suppressed BLM-induced lung fibrosis characterized as the inhibition of collagen deposition, TGF-β accumulation in bronchoalveolar lavage fluid, and the expression of FN and collagen 1a2 in lung tissue.
|
31553994 |
2019 |
Pulmonary Fibrosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
MiR-34b-5p knockdown in vivo attenuated the bleomycin-induced pulmonary fibrosis in wild-type mice, displayed by a reduced expression of Col1A1, fibronectin (Fn), and α-SMA.
|
30915776 |
2019 |
Pulmonary Fibrosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The occurrence and progression of lung fibrosis, the extracellular matrix-related molecules such as integrins and their ligands including fibronectin, vitronectin, laminin, and collagens, all play important roles.
|
31130697 |
2019 |
Pulmonary Fibrosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our study showed ouabain significantly reduce α-SMA, fibronectin and collagen I expression in lung fibrosis animal model.
|
30323883 |
2018 |
Pulmonary Fibrosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, dual immunofluorescence staining for E-cadherin and fibronectin demonstrated that rapamycin pretreatment decreased the proportions of AECs undergoing EMT in bleomycin-induced pulmonary fibrosis, indicating that mTOR inhibition suppressed EMT in vivo.
|
29704504 |
2018 |
Pulmonary Fibrosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Withaferin A treatment reduced the progression of PF by modulating the EMT related cell markers both <i>in vivo</i> and <i>in vitro.</i> Withaferin A ameliorated the expression of inflammatory cytokines including NF-κB p65, IL-1β and TNF-α, as well as attenuated the expression of pro-fibrotic proteins including CTGF, collagen 1A2, collagen 3A1, and fibronectin.
|
29623041 |
2018 |
Pulmonary Fibrosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition, in primary myofibroblast-like cells that were obtained from a patient with pulmonary fibrosis, treatment with CsA and an HIF-1α inhibitor (HIFi) decreased the expression levels of α-smooth muscle actin and fibronectin, which indicated that CsA and HIFi promote dedifferentiation of myofibroblasts.
|
28446589 |
2017 |
Pulmonary Fibrosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The changes in histone acetylation may directly regulate the gene expression of inflammatory cytokines/fibronectin and thus affect the progression of pulmonary fibrosis.
|
28961490 |
2017 |
Pulmonary Fibrosis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Self-assembled Micelle Interfering RNA for Effective and Safe Targeting of Dysregulated Genes in Pulmonary Fibrosis.
|
26817844 |
2016 |
Pulmonary Fibrosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In vivo neutralization of sIL-6Rα attenuated pulmonary fibrosis in mice as seen by reductions in myofibroblasts, fibronectin, and collagen in the lung.
|
25172494 |
2014 |
Pulmonary Fibrosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We have previously shown that insulin-like growth factor (IGF) binding protein- 5 (IGFBP-5) is overexpressed in lung fibrosis and induces the production of extracellular matrix components, such as collagen and fibronectin, both in vitro and in vivo.
|
19628764 |
2009 |
Pulmonary Fibrosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our study investigated whether polymorphisms of the fibronectin gene are associated with lung fibrosis in SSc.
|
9870923 |
1999 |
Pulmonary Fibrosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Fibronectin as well as other pulmonary cytokines are essential participants in efficient and orderly wound repair; however, the excessive production of these mediators may result in an exaggeration of the normal healing process with the eventual outcome of pulmonary fibrosis.
|
1514107 |
1992 |