FN1, fibronectin 1, 2335

N. diseases: 724; N. variants: 33
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.400 AlteredExpression disease BEFREE Administration of lentivirus coding mouse P120 sh-RNA into mouse lung tissue dramatically attenuated the expression of P120 in lung tissue and lung fibroblast, suppressed BLM induced increase of TGF-β, alpha smooth muscle actin (α-SMA) and fibronectin (FN) expression, and decreased the deposition of collagen and pulmonary fibrosis. 31125560 2019
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.400 Biomarker disease BEFREE Here, we found that BLM-induced lung fibrosis with thickened interstitial lung tissue, including fibronectin and collagen, was correlated with the increased serum concentrations of IL-6 and IL-33 and accompanied by reduced lung function, including FRC (functional residual capacity), C chord (lung compliance), IC (inspiratory capacity), VC (vital capacity), TLC (total lung capacity), and FVC (forced vital capacity) (<i>p</i> < 0.05). 31049028 2019
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.400 AlteredExpression disease BEFREE The administration of SA (IP) suppressed BLM-induced lung fibrosis characterized as the inhibition of collagen deposition, TGF-β accumulation in bronchoalveolar lavage fluid, and the expression of FN and collagen 1a2 in lung tissue. 31553994 2019
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.400 AlteredExpression disease BEFREE MiR-34b-5p knockdown in vivo attenuated the bleomycin-induced pulmonary fibrosis in wild-type mice, displayed by a reduced expression of Col1A1, fibronectin (Fn), and α-SMA. 30915776 2019
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.400 Biomarker disease BEFREE The occurrence and progression of lung fibrosis, the extracellular matrix-related molecules such as integrins and their ligands including fibronectin, vitronectin, laminin, and collagens, all play important roles. 31130697 2019
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.400 AlteredExpression disease BEFREE Our study showed ouabain significantly reduce α-SMA, fibronectin and collagen I expression in lung fibrosis animal model. 30323883 2018
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.400 Biomarker disease BEFREE In addition, dual immunofluorescence staining for E-cadherin and fibronectin demonstrated that rapamycin pretreatment decreased the proportions of AECs undergoing EMT in bleomycin-induced pulmonary fibrosis, indicating that mTOR inhibition suppressed EMT in vivo. 29704504 2018
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.400 AlteredExpression disease BEFREE Withaferin A treatment reduced the progression of PF by modulating the EMT related cell markers both <i>in vivo</i> and <i>in vitro.</i> Withaferin A ameliorated the expression of inflammatory cytokines including NF-κB p65, IL-1β and TNF-α, as well as attenuated the expression of pro-fibrotic proteins including CTGF, collagen 1A2, collagen 3A1, and fibronectin. 29623041 2018
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.400 AlteredExpression disease BEFREE In addition, in primary myofibroblast-like cells that were obtained from a patient with pulmonary fibrosis, treatment with CsA and an HIF-1α inhibitor (HIFi) decreased the expression levels of α-smooth muscle actin and fibronectin, which indicated that CsA and HIFi promote dedifferentiation of myofibroblasts. 28446589 2017
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.400 AlteredExpression disease BEFREE The changes in histone acetylation may directly regulate the gene expression of inflammatory cytokines/fibronectin and thus affect the progression of pulmonary fibrosis. 28961490 2017
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.400 Biomarker disease CTD_human Self-assembled Micelle Interfering RNA for Effective and Safe Targeting of Dysregulated Genes in Pulmonary Fibrosis. 26817844 2016
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.400 Biomarker disease BEFREE In vivo neutralization of sIL-6Rα attenuated pulmonary fibrosis in mice as seen by reductions in myofibroblasts, fibronectin, and collagen in the lung. 25172494 2014
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.400 AlteredExpression disease BEFREE We have previously shown that insulin-like growth factor (IGF) binding protein- 5 (IGFBP-5) is overexpressed in lung fibrosis and induces the production of extracellular matrix components, such as collagen and fibronectin, both in vitro and in vivo. 19628764 2009
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.400 GeneticVariation disease BEFREE Our study investigated whether polymorphisms of the fibronectin gene are associated with lung fibrosis in SSc. 9870923 1999
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.400 Biomarker disease BEFREE Fibronectin as well as other pulmonary cytokines are essential participants in efficient and orderly wound repair; however, the excessive production of these mediators may result in an exaggeration of the normal healing process with the eventual outcome of pulmonary fibrosis. 1514107 1992