|
Ureteral obstruction
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
We found that ETS2 and profibrogenic factors, alpha-smooth muscle actin (α-SMA) and fibronectin (FN), were significantly increased in the unilateral ureteral obstruction (UUO)-induced renal fibrosis model in mice.
|
31641227 |
2020 |
|
Ureteral obstruction
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The pathological changes, collagen deposition, and protein expressions of profibrotic factors (transforming growth factor-β and connective tissue growth factor) and fibrotic markers (α-smooth muscle actin and fibronectin), which were significantly elevated in the kidneys of UUO mice, could be significantly reversed by icariin treatment.
|
30978648 |
2019 |
|
Ureteral obstruction
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
The levels of collagen I, fibronectin and α‑smooth muscle actin were increased by UUO in mice or by transforming growth factor (TGF)‑β1 treatment in NRK‑52E cells, and were reduced by ASX administration.
|
30816496 |
2019 |
|
Ureteral obstruction
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
An in vivo study revealed that petA protected against renal inflammation and fibrosis by reducing the infiltration of macrophages, inhibiting the expression of proinflammatory cytokines (interleukin-1β and tumour necrosis factor-α) and reducing extracellular matrix deposition (α-smooth muscle actin, collagen I and fibronectin) in the obstructed kidney of UUO mice; these changes were associated with suppression of Smad3 and NF-κB p65 phosphorylation.
|
31211499 |
2019 |
|
Ureteral obstruction
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Tamoxifen treatment ameliorated UUO-induced renal fibrosis as shown by decreased expression of α-smooth muscle actin (SMA), fibronectin and connective tissue growth factor (CTGF).
|
30304547 |
2019 |
|
Ureteral obstruction
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Compared with UUO group, the renal collagen deposition in transplantation group was significantly reduced, and the expressions of α-SMA mRNA and protein were significantly decreased, while the expressions of HGF mRNA and protein were significantly increased, and the expression of FN mRNA was significantly decreased (P<0.001).
|
31411175 |
2019 |
|
Ureteral obstruction
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Immunohistochemical staining showed that TGF-β1 and Fibronectin expressions were significantly decreased in UUO mice compared with sham group.
|
30215298 |
2019 |
|
Ureteral obstruction
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Administration of MC1568 immediately after UUO injury reduced expression of α-smooth muscle actin (α-SMA), fibronectin, and collagen 1.
|
30951378 |
2019 |
|
Ureteral obstruction
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
A series of experiments showed the EGFR mimotope immunization could ameliorate renal fibrosis, reduce the expressions of fibronectin, α-SMA and collagen I and alleviate the infiltrations of F4/80+ macrophages in UUO model.
|
31152892 |
2019 |
|
Ureteral obstruction
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
In vivo, PEG-FUD significantly decreased fibronectin by ~70% in UUO kidneys as determined by both IHC and immunoblotting, respectively.
|
30356276 |
2018 |
|
Ureteral obstruction
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Masson staining, immunohistochemistry, and real-time PCR showed significantly decreased extracellular matrix deposition, fibronectin staining intensity, and RNA levels of collagen I and collagen III in SIS3-treated UUO kidneys.
|
29555895 |
2018 |
|
Ureteral obstruction
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
The results indicated that UUO increased collagen deposition and the mRNA expression of fibronectin (FN) and collagen type I alpha 1 (Col1α1) in the obstructed kidney tissues.
|
29530599 |
2018 |
|
Ureteral obstruction
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
We compared Nrf2+/+ and Nrf2-/- mice following UUO in tubular damage, transdifferentiation [vimentin, proliferating cell nuclear antigen (PCNA)], fibrosis [fibronectin, α-smooth muscle actin (SMA)], antioxidative and inflammatory responses.
|
29126308 |
2018 |
|
Ureteral obstruction
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Therapeutically, adoptive transfer of legumain-overexpressing macrophages or IL4-stimulated macrophages ameliorated the deposition of collagen and fibronectin induced by ureteral obstruction, either in the wild-type mice or in lgmn<sup>-/-</sup> mice.
|
29656902 |
2018 |
|
Ureteral obstruction
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
CTS also inhibited expression of fibronectin, collagen-1 but retain E-cadherin in the UUO model.
|
30101622 |
2018 |
|
Ureteral obstruction
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
The expression levels of cleaved caspase-3, ED-1, and fibronectin were decreased in UUO animals.
|
28298077 |
2018 |
|
Ureteral obstruction
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The results demonstrated that HES reduced obstruction-induced renal injury and deposition of the extracellular matrix components collagen-I and fibronectin in UUO mouse kidneys (P<0.05).
|
29042968 |
2017 |
|
Ureteral obstruction
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Inhibiting Brd4 with either JQ1 or genetic knockdown resulted in decreased expression of fibrotic genes such as α-smooth muscle actin, collagen IV and fibronectin both in UUO-induced fibrosis and upon TGF-β1 stimulation in HK-2 cells.
|
28063381 |
2017 |
|
Ureteral obstruction
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Functionally, Sphk2-deficient (Sphk2<sup>-/-</sup>) mice showed an attenuated fibrotic response to UUO compared with wild-type mice, as demonstrated by reduced collagen abundance and decreased expression of fibronectin-1, collagen I, α-smooth muscle actin, connective tissue growth factor (CTGF), and plasminogen activator inhibitor (PAI-1).
|
28807595 |
2017 |
|
Ureteral obstruction
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
The antihelmenthic phosphate niclosamide impedes renal fibrosis by inhibiting homeodomain-interacting protein kinase 2 expression.
|
28318631 |
2017 |
|
Ureteral obstruction
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
In keeping with the in vitro findings, Cyp2j4(-/-) rats show upregulation of type I collagen following unilateral ureter obstruction of the kidney, and quantitative proteomics analysis (liquid chromatography-tandem mass spectrometry) showed increased renal type I collagen and fibronectin protein abundance resulting from experimentally induced crescentic glomerulonephritis in these rats.
|
25840911 |
2015 |
|
Ureteral obstruction
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
EW-7197 decreased the expression of collagen, α-smooth muscle actin (α-SMA), fibronectin, 4-hydroxy-2, 3-nonenal, and integrins in the livers of CCl4 mice and BDL rats, in the lungs of BLM mice, and in the kidneys of UUO mice.
|
25487606 |
2015 |
|
Ureteral obstruction
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
PXS 64 treated UUO mice had a lower tubulointerstitial fibrosis index, collagen IV and fibronectin protein and mRNA expression when compared to untreated UUO mice.
|
25658916 |
2015 |
|
Ureteral obstruction
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Finally, DMF suppressed unilateral ureteral obstruction (UUO)-induced renal fibrosis and α-SMA, fibronectin and type 1 collagen expression in the obstructed kidneys from UUO mice, along with increased and decreased expression of Nrf2 and phospho-Smad3, respectively.
|
23056222 |
2012 |
|
Ureteral obstruction
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
The UUO kidneys from kl/+ mice expressed significantly higher levels of fibrosis markers such as α-smooth muscle actin (α-SMA), fibronectin, and transforming growth factor-β(1) (TGF-β(1)) than those from wild-type mice.
|
22338084 |
2012 |