Osteosarcoma
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Inhibition of OS cell growth and invasion were associated with release of high levels of mature miR-34a from pre-miR-34a prodrug and consequently reduction of protein levels of many miR-34a target genes including SIRT1, BCL2, c-MET, and CDK6.
|
27216562 |
2016 |
Osteosarcoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
In summary, high levels of SIRT1 may be a biomarker for a high metastatic rate in osteosarcoma patients; inhibiting SIRT1 could be a potent therapeutic intervention for these patients.
|
27793039 |
2016 |
Osteosarcoma
|
0.390 |
Biomarker
|
disease |
CTD_human |
In summary, high levels of SIRT1 may be a biomarker for a high metastatic rate in osteosarcoma patients; inhibiting SIRT1 could be a potent therapeutic intervention for these patients.
|
27793039 |
2016 |
Osteosarcoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Therefore, the present study demonstrated that miR-138 has a role in inhibiting OS cell proliferation and invasion via directly targeting SIRT1, and suggested that the miR-138/SIRT1 axis may become a promising therapeutic target for OS.
|
28587420 |
2017 |
Osteosarcoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
We obtained evidence that SIRT1 impairs LKB1 protein stability, and that SIRT1 depletion leads to accumulation of LKB1 in OS cell lines resulting in growth arrest.
|
28632727 |
2017 |
Osteosarcoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Taken together, these findings will shed light on the role and mechanism of miR-133b in regulating osteosarcoma cell growth via the miR-133b/Sirt1 axis, and miR-133b may serve as a potential therapeutic target in osteosarcoma in the future.
|
28059051 |
2017 |
Osteosarcoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
The expressions of C2dat1, miR-34a-5p, and Sirt1 in human osteosarcoma cells were altered by transfection with their specific vectors/shRNA or mimic/inhibitor.
|
28810936 |
2018 |
Osteosarcoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
In this perspective, we emphasize the current advances and interactions involving the insulin/IGF1R, SIRT1, and FOXOs pathways in the bone and osteosarcoma for a better understanding of the mechanisms potentially underpinning tissue degeneration and tumorigenesis.
|
30881341 |
2019 |
Osteosarcoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Moreover, Sirt1 facilitated osteosarcoma cell autophagy under starvation condition.
|
31390921 |
2019 |
Osteosarcoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Altogether, the results of the current study revealed that high levels of SIRT1 might be a biomarker for a high metastatic rate in patients with osteosarcoma, which suggested that inhibition of SIRT1 might be promising for the therapeutics of osteosarcoma.
|
30304565 |
2019 |