SIRT1, sirtuin 1, 23411

N. diseases: 675; N. variants: 21
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.390 Biomarker disease BEFREE Therefore, our findings suggested that miR‑217 inhibitor protected against retinal epithelial cell damage caused by high glucose via targeting SIRT1, thereby playing a protective role in diabetic retinopathy. 31702814 2019
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.390 AlteredExpression disease BEFREE Fenofibrate facilitates the expression of SIRT1 in the retinal tissues to reduce the NF-κB activity, thereby treating DR in rats. 31646597 2019
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.390 Biomarker disease BEFREE Cross-Talk between Sirtuin 1 and the Proinflammatory Mediator High-Mobility Group Box-1 in the Regulation of Blood-Retinal Barrier Breakdown in Diabetic Retinopathy. 31136205 2019
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.390 Biomarker disease BEFREE In conclusion, SIRT1 regulates apoptosis, inflammation and oxidative stress resulting in improving DR. 29091865 2018
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.390 Biomarker disease BEFREE Thus strategies targeted to ameliorate Sirt1 inhibition have the potential to maintain retinal vascular and neuronal homeostasis, providing opportunities to retard the development of diabetic retinopathy in its early stages. 29311218 2018
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.390 Biomarker disease BEFREE Serum microRNA-211 as a biomarker for diabetic retinopathy via modulating Sirtuin 1. 30333091 2018
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.390 Biomarker disease BEFREE In vitro results were validated in the retina from diabetic mice overexpressing Sirt1, and in the retinal microvessels from human donors with diabetic retinopathy. 26599598 2016
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.390 AlteredExpression disease BEFREE The aim of the present study was to investigate the inhibitory effect of fenofibrate on metabolic memory (via the regulation of SIRT1), and inflammatory responses in cell and animal models of diabetic retinopathy (DR). 26238659 2015
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.390 Biomarker disease BEFREE These studies identified a novel mechanism whereby miR-195 regulates SIRT1-mediated tissue damage in diabetic retinopathy. 24570140 2014
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.390 Biomarker disease CTD_human The goal of this study is to investigate the role of Sirt1 in the activation of MMP-9 in diabetic retinopathy. 24894401 2014