Insulin Resistance
|
0.500 |
Biomarker
|
phenotype |
CTD_human |
Together, these studies highlight the therapeutic relevance of targeting duodenal SIRT1 to reverse insulin resistance and improve glucose homeostasis in obesity and diabetes.
|
25849131 |
2015 |
Insulin Resistance
|
0.500 |
Biomarker
|
phenotype |
CTD_human |
Sirt1 mediates the effect of the heme oxygenase inducer, cobalt protoporphyrin, on ameliorating liver metabolic damage caused by a high-fat diet.
|
26026874 |
2015 |
Insulin Resistance
|
0.500 |
Therapeutic
|
phenotype |
CTD_human |
Together, these studies highlight the therapeutic relevance of targeting duodenal SIRT1 to reverse insulin resistance and improve glucose homeostasis in obesity and diabetes.
|
25849131 |
2015 |
Insulin Resistance
|
0.500 |
Therapeutic
|
phenotype |
CTD_human |
Sirt1 mediates the effect of the heme oxygenase inducer, cobalt protoporphyrin, on ameliorating liver metabolic damage caused by a high-fat diet.
|
26026874 |
2015 |
Insulin Resistance
|
0.500 |
Therapeutic
|
phenotype |
CTD_human |
In addition, constant darkness-induced circadian misalignment in mice decreases hepatic BMAL1 and SIRT1 levels and induces IR, which can be dramatically reversed by resveratrol.
|
24442997 |
2014 |
Insulin Resistance
|
0.500 |
Biomarker
|
phenotype |
CTD_human |
In addition, constant darkness-induced circadian misalignment in mice decreases hepatic BMAL1 and SIRT1 levels and induces IR, which can be dramatically reversed by resveratrol.
|
24442997 |
2014 |
Insulin Resistance
|
0.500 |
Therapeutic
|
phenotype |
CTD_human |
These studies indicate that SIRT1 serves as a negative regulator of UPR signaling in T2DM and that SIRT1 attenuates hepatic steatosis, ameliorates insulin resistance, and restores glucose homeostasis, largely through the inhibition of mTORC1 and ER stress.
|
21321189 |
2011 |
Insulin Resistance
|
0.500 |
Biomarker
|
phenotype |
CTD_human |
These studies indicate that SIRT1 serves as a negative regulator of UPR signaling in T2DM and that SIRT1 attenuates hepatic steatosis, ameliorates insulin resistance, and restores glucose homeostasis, largely through the inhibition of mTORC1 and ER stress.
|
21321189 |
2011 |
Insulin Resistance
|
0.500 |
Therapeutic
|
phenotype |
CTD_human |
In vivo, insulin resistance and metabolic syndrome were associated with low PBMC SIRT1 gene and protein expression.
|
20068143 |
2010 |
Insulin Resistance
|
0.500 |
Biomarker
|
phenotype |
CTD_human |
In vivo, insulin resistance and metabolic syndrome were associated with low PBMC SIRT1 gene and protein expression.
|
20068143 |
2010 |
Insulin Resistance
|
0.500 |
Therapeutic
|
phenotype |
RGD |
In conclusion, these results define a novel role for SIRT1 as an important regulator of macrophage inflammatory responses in the context of insulin resistance and raise the possibility that targeting of SIRT1 might be a useful strategy for treating the inflammatory component of metabolic diseases.
|
19996381 |
2010 |