TARDBP, TAR DNA binding protein, 23435

N. diseases: 245; N. variants: 36
Disease: Amyotrophic Lateral Sclerosis With Dementia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0393554
Disease: Amyotrophic Lateral Sclerosis With Dementia
Amyotrophic Lateral Sclerosis With Dementia 		0.300 Biomarker disease CTD_human A high-content screen identifies novel compounds that inhibit stress-induced TDP-43 cellular aggregation and associated cytotoxicity. 24019256 2014
CUI: C0393554
Disease: Amyotrophic Lateral Sclerosis With Dementia
Amyotrophic Lateral Sclerosis With Dementia 		0.300 Biomarker disease CTD_human Reducing TDP-43 aggregation does not prevent its cytotoxicity. 24252504 2013
CUI: C0393554
Disease: Amyotrophic Lateral Sclerosis With Dementia
Amyotrophic Lateral Sclerosis With Dementia 		0.300 Biomarker disease CTD_human Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models. 23104007 2012
CUI: C0393554
Disease: Amyotrophic Lateral Sclerosis With Dementia
Amyotrophic Lateral Sclerosis With Dementia 		0.300 Biomarker disease CTD_human Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes. 22879928 2012
CUI: C0393554
Disease: Amyotrophic Lateral Sclerosis With Dementia
Amyotrophic Lateral Sclerosis With Dementia 		0.300 Biomarker disease CTD_human Inorganic mercury within motor neurons does not cause the TDP-43 changes seen in sporadic ALS. 21167262 2011
CUI: C0393554
Disease: Amyotrophic Lateral Sclerosis With Dementia
Amyotrophic Lateral Sclerosis With Dementia 		0.300 Biomarker disease CTD_human TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis. 18372902 2008