FOLR1, folate receptor alpha, 2348

N. diseases: 174; N. variants: 8
Disease: Malignant tumor of colon ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.310 Biomarker disease BEFREE The supramolecular complex of Ad-HA/FA-M-β-CyD showed higher cytotoxic activity in HCT116 cells (FR-α (+), CD44 (+)), a human colon cancer cell line, than FA-M-β-CyD alone. 29486262 2018
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.310 Biomarker disease CTD_human Use of a novel genetic mouse model to investigate the role of folate in colitis-associated colon cancer. 18926688 2009
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.310 Biomarker disease CTD_human In conclusion, Folbp1 and RFC1 genetically modified mice exhibit distinct changes in colonocyte phenotype and therefore have utility as models to examine the role of folate homeostasis in colon cancer development. 15705887 2005