|
Malignant Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Here, we show a novel and direct association between a constituent of the PRC1 complex, CBX7, with gene repression and promoter DNA hypermethylation of genes frequently silenced in cancer.
|
19602592 |
2009 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Chromobox protein homologue 7 (CBX7) is a chromobox family protein encoding a novel polycomb protein, the expression of which shows a progressive reduction, well related with the malignant grade of the thyroid neoplasias.
|
19706751 |
2009 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
To elucidate the function of CBX7 in carcinogenesis, we searched for CBX7 interacting proteins by a proteomic analysis.
|
19706751 |
2009 |
|
Primary malignant neoplasm
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Here, we show a novel and direct association between a constituent of the PRC1 complex, CBX7, with gene repression and promoter DNA hypermethylation of genes frequently silenced in cancer.
|
19602592 |
2009 |
|
Thyroid carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Consistent with these data, we found a positive statistical correlation between CBX7 and E-cadherin expression in human thyroid carcinomas.
|
19706751 |
2009 |
|
Adenoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Indeed, CBX7 protein levels decreased in an increasing percentage of cases going from benign adenomas to papillary, follicular, and anaplastic thyroid carcinomas.
|
19706751 |
2009 |
|
Embryonal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knockdown of CBX7 was unable to relieve suppression of deeply silenced genes in cancer cells; however, in embryonal carcinoma (EC) cells, CBX7 can initiate stable repression of genes that are frequently silenced in adult cancers.
|
19602592 |
2009 |
|
Anaplastic thyroid carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Indeed, CBX7 protein levels decreased in an increasing percentage of cases going from benign adenomas to papillary, follicular, and anaplastic thyroid carcinomas.
|
19706751 |
2009 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Loss of CBX7 expression was associated with increasing malignancy grade in pancreatic adenocarcinoma, whereas the maintenance of CBX7 expression showed a trend toward a longer survival.
|
20185297 |
2010 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The role of CBX7 in most types of cancer is still not clear.
|
20723236 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Chromobox 7 (CBX7) is a Polycomb family protein that extends the lifespan of normal human cells via downregulating the expression of INK4a/ARF tumor suppressor locus.
|
20723236 |
2010 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Aim of this study was to investigate the role of PcG protein CBX7 in pancreatic carcinogenesis and to evaluate its possible diagnostic and prognostic significance.
|
20185297 |
2010 |
|
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Finally, the restoration of CBX7 expression in two CRC cell lines reduces their proliferation rate suggesting a role of the loss of CBX7 expression in the progression step of colon carcinogenesis.
|
20542683 |
2010 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
CBX7 acts as an oncogene in the carcinogenesis and progression of gastric cancer, and it may regulate tumorigenesis, cell migration and cancer metastasis partially via p16(INK4a) regulatory pathway.
|
20723236 |
2010 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
The role of CBX7 in most types of cancer is still not clear.
|
20723236 |
2010 |
|
Primary malignant neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Loss of CBX7 expression was associated with increasing malignancy grade in pancreatic adenocarcinoma, whereas the maintenance of CBX7 expression showed a trend toward a longer survival.
|
20185297 |
2010 |
|
Thyroid carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
We have previously shown that CBX7 expression is associated with a more malignant phenotype in thyroid cancer.
|
20542683 |
2010 |
|
Malignant neoplasm of stomach
|
0.030 |
Biomarker
|
disease |
BEFREE |
The purpose of this study is to investigate the role of CBX7 in gastric cancer.
|
20723236 |
2010 |
|
Malignant neoplasm of pancreas
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Loss of the CBX7 protein expression correlates with a more aggressive phenotype in pancreatic cancer.
|
20185297 |
2010 |
|
Stomach Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The purpose of this study is to investigate the role of CBX7 in gastric cancer.
|
20723236 |
2010 |
|
Malignant neoplasm of thyroid
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We have previously shown that CBX7 expression is associated with a more malignant phenotype in thyroid cancer.
|
20542683 |
2010 |
|
Kidney Failure, Acute
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Chromobox 7 (CBX7) is a Polycomb family protein that extends the lifespan of normal human cells via downregulating the expression of INK4a/ARF tumor suppressor locus.
|
20723236 |
2010 |
|
Rheumatic Fever
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Chromobox 7 (CBX7) is a Polycomb family protein that extends the lifespan of normal human cells via downregulating the expression of INK4a/ARF tumor suppressor locus.
|
20723236 |
2010 |
|
Thyroid Neoplasm
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We have previously shown that CBX7 expression is associated with a more malignant phenotype in thyroid cancer.
|
20542683 |
2010 |
|
Pancreatic carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Loss of the CBX7 protein expression correlates with a more aggressive phenotype in pancreatic cancer.
|
20185297 |
2010 |