|
Triple Negative Breast Neoplasms
|
0.010 |
Biomarker
|
disease |
BEFREE |
TACI silencing can be a new and promising therapeutic target for mesenchymal-stem like triple-negative breast cancer subtype.
|
31400636 |
2020 |
|
Triple-Negative Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
TACI silencing can be a new and promising therapeutic target for mesenchymal-stem like triple-negative breast cancer subtype.
|
31400636 |
2020 |
|
Deglutition Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
The factors that were associated with dysphagia were age > 74 years (OR 1.99), TACI (OR 5.82), mRS score ≥ 3 (OR 4.31), malnutrition (OR 3.27), and BMI ≥ 20 (OR 0.45).
|
31004231 |
2019 |
|
IGA Glomerulonephritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that APRIL is involved in the hyperproduction of IgA from IgAN-TMCs, and that CpG-ODN enhanced APRIL-induced IgA production by increasing TACI expression on B-cells of IgAN-TMCs.
|
31088610 |
2019 |
|
Rubinstein-Taybi Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Immunoglobulin Replacement Therapy (IRT) was effective with a good hematological values control in three patients with a secondary ES (ALPS, CVID, and a patient with Rubinstein Taybi Syndrome and a progressive severe B cell deficiency with hypogammaglobulinemia).
|
31396497 |
2019 |
|
Malnutrition
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The factors that were associated with dysphagia were age > 74 years (OR 1.99), TACI (OR 5.82), mRS score ≥ 3 (OR 4.31), malnutrition (OR 3.27), and BMI ≥ 20 (OR 0.45).
|
31004231 |
2019 |
|
Pelvic Inflammatory Disease
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Our patient incompletely met ESID diagnostic criteria for CVID, but molecular genetic analysis, a NGS panel including 47 PID-associated genes was performed in the proband and in his parents, revealing the presence of a heterozygous nucleotide substitution in exon 4 (c.579C>A) of <i>TNFRSF13B</i> encoding TACI.
|
31681716 |
2019 |
|
Evans syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Immunoglobulin Replacement Therapy (IRT) was effective with a good hematological values control in three patients with a secondary ES (ALPS, CVID, and a patient with Rubinstein Taybi Syndrome and a progressive severe B cell deficiency with hypogammaglobulinemia).
|
31396497 |
2019 |
|
Gastrointestinal symptom
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
CVID_QoL global score and its dimensions (emotional functioning, relational functioning, gastrointestinal symptoms) were similar in IVIG, SCIG, and fSCIG recipients.
|
30644015 |
2019 |
|
Humoral immune defect
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Immunoglobulin Replacement Therapy (IRT) was effective with a good hematological values control in three patients with a secondary ES (ALPS, CVID, and a patient with Rubinstein Taybi Syndrome and a progressive severe B cell deficiency with hypogammaglobulinemia).
|
31396497 |
2019 |
|
Immunosuppression
|
0.010 |
Biomarker
|
disease |
BEFREE |
APRIL signaling via TACI mediates immunosuppression by T regulatory cells in multiple myeloma: therapeutic implications.
|
30135465 |
2019 |
|
refractory multiple myeloma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that using a trimeric rather than a monomeric APRIL format as the antigen-binding domain enhanced binding to BCMA and TACI and CART activity against MM in vitro and in vivo.
|
31698455 |
2019 |
|
Enterovirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Deep sequencing was used to determine complete nucleotide sequences of echovirus 11 (EV11) strains isolated from a chronically infected patient with CVID as well as from cases of acute enterovirus infection.
|
29554133 |
2018 |
|
Glioblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The decision tree analysis of CSF TACI and BAFF levels for patients with a PCNSL diagnosis showed 100% sensitivity and 100% specificity when we attempted to differentiate PCNSL from glioblastoma and CNS inflammatory diseases.
|
30564626 |
2018 |
|
Kidney Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Whereas transgenic mice overexpressing BAFF develop progressive membranoproliferative glomerulonephritis, albuminuria and renal dysfunction, TACI deletion in BAFF-transgenic mice provided long-term (about 1 year) protection from renal disease.
|
29907458 |
2018 |
|
Rheumatism
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Physician-reported rheumatic diseases were present in 5.9% of patients with CVID (n = 51) included in the registry.
|
29599028 |
2018 |
|
Adult Glioblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The decision tree analysis of CSF TACI and BAFF levels for patients with a PCNSL diagnosis showed 100% sensitivity and 100% specificity when we attempted to differentiate PCNSL from glioblastoma and CNS inflammatory diseases.
|
30564626 |
2018 |
|
Childhood Glioblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The decision tree analysis of CSF TACI and BAFF levels for patients with a PCNSL diagnosis showed 100% sensitivity and 100% specificity when we attempted to differentiate PCNSL from glioblastoma and CNS inflammatory diseases.
|
30564626 |
2018 |
|
Granulomatous disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
Further examination of underweight patients by PID diagnosis revealed that underweight status in adults with CVID was associated with granulomatous disease as well as earlier age of CVID diagnosis.
|
29619656 |
2018 |
|
Kabuki make-up syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
A 16-year-old girl with Kabuki syndrome and a 12-year-old boy, both with a CVID-like humoral immunodeficiency on immunoglobulin replacement treatment, developed during follow-up an inflammatory complication radiologically, clinically, and histologically compatible with GLILD.
|
29532571 |
2018 |
|
Glioblastoma Multiforme
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The decision tree analysis of CSF TACI and BAFF levels for patients with a PCNSL diagnosis showed 100% sensitivity and 100% specificity when we attempted to differentiate PCNSL from glioblastoma and CNS inflammatory diseases.
|
30564626 |
2018 |
|
Encephalomyelitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
On blockade of the effects of BAFF with TACI-IgG, IL-10<sup>+</sup> Bregs were upregulated in MRL/lpr and EAE mice.
|
28199852 |
2017 |
|
Lupus Vulgaris
|
0.010 |
Biomarker
|
disease |
BEFREE |
We showed that BAFF could induce IL-35 production by a unique CD5<sup>+</sup>CD1d<sup>hi</sup>FcγRIIb<sup>hi</sup> regulatory B-cell subset mainly through TACI activation in lupus, providing an advanced understanding of the regulatory effect of BAFF in autoimmune diseases.
|
28844943 |
2017 |
|
Lupus Erythematosus, Discoid
|
0.010 |
Biomarker
|
disease |
BEFREE |
We showed that BAFF could induce IL-35 production by a unique CD5<sup>+</sup>CD1d<sup>hi</sup>FcγRIIb<sup>hi</sup> regulatory B-cell subset mainly through TACI activation in lupus, providing an advanced understanding of the regulatory effect of BAFF in autoimmune diseases.
|
28844943 |
2017 |
|
Autoimmune thrombocytopenia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A gain-of-function mutation in TNFRSF13B is a candidate for predisposition to familial or sporadic immune thrombocytopenia.
|
28834165 |
2017 |