Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.310 Biomarker disease CTD_human Selective inhibition of tumor oncogenes by disruption of super-enhancers. 23582323 2013
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.310 Biomarker disease CTD_human Selective inhibition of tumor oncogenes by disruption of super-enhancers. 23582323 2013
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.310 AlteredExpression disease BEFREE Furthermore, among 2422 genes that correlated with the degree of necrosis in GBMs, transcription factors known to drive the mesenchymal expression class were most closely related, including C/EBP-β, C/EBP-δ, STAT3, FOSL2, bHLHE40, and RUNX1. 22440258 2012
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.310 AlteredExpression disease BEFREE Furthermore, among 2422 genes that correlated with the degree of necrosis in GBMs, transcription factors known to drive the mesenchymal expression class were most closely related, including C/EBP-β, C/EBP-δ, STAT3, FOSL2, bHLHE40, and RUNX1. 22440258 2012
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 Biomarker disease BEFREE Immunoreactivity of IL-1α and IL-1β was increased in Fra-2 TG mice and in patients with SSc. 31320452 2019
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 Biomarker disease BEFREE Fra-2 overexpressing mice were initially described as a model of systemic sclerosis associated organ fibrosis, with predominant alterations in the lung. 31473307 2019
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.300 Biomarker group CTD_human Bronchial airway gene expression signatures in mouse lung squamous cell carcinoma and their modulation by cancer chemopreventive agents. 27935865 2017
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 GeneticVariation disease BEFREE The aim of this study was to analyse the effects of nintedanib in the fos-related antigen-2 (Fra2) mouse model of systemic sclerosis (SSc). 28814429 2017
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 Biomarker disease BEFREE In this study we analyzed how blocking TGFβ signaling affects pulmonary abnormalities in Fos-related antigen 2 (Fra-2) transgenic (Tg) mice, a murine model that manifests three important lung pathological features of SSc: fibrosis, inflammation, and vascular remodeling. 27864286 2017
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 AlteredExpression disease BEFREE Exogenous delivery of microRNA-5196 reduced Fra2 and TIMP-1 expression suggesting that it may be used as a potential modulator of fibrogenesis in SSc. 28639412 2017
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 Biomarker disease BEFREE Consistent with these observations, a strong MMP10 staining of the thickened wall of distal pulmonary arteries was found both in the lungs of patients with SSc-associated PH and in the lungs of Fra-2-Tg mice. 28805015 2017
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.300 Biomarker disease CTD_human Bronchial airway gene expression signatures in mouse lung squamous cell carcinoma and their modulation by cancer chemopreventive agents. 27935865 2017
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 Biomarker disease BEFREE Under this situation, three new genetic animal models have recently been established, such as Fra2 transgenic mice, urokinase-type plasminogen activator receptor deficient mice and Klf5(+/-) ;Fli1(+/-) mice, all of which recapitulate the pathological cascade of SSc. 26782003 2016
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 Biomarker disease BEFREE We demonstrate that all typical manifestations of SSc-related cardiomyopathy are mimicked in Fra-2-transgenic mice. 25371068 2015
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 Biomarker disease BEFREE The Fra-2 (Fos-related antigen-2) transgenic mouse model simultaneously displays both pro-fibrotic and vascular characteristics of human systemic sclerosis. 23232070 2013
CUI: C0334588
Disease: Giant Cell Glioblastoma
Giant Cell Glioblastoma 		0.300 Biomarker disease CTD_human Selective inhibition of tumor oncogenes by disruption of super-enhancers. 23582323 2013
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 Biomarker disease BEFREE Abnormal expression of transcription factors, including Fra2 and Fli1, has been proposed to contribute to SSc vasculopathy. 20585340 2010
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 AlteredExpression disease BEFREE Stimulation with TGFbeta and platelet-derived growth factor (PDGF) significantly increased the expression of Fra-2 in SSc fibroblasts and induced DNA binding of Fra-2 in an ERK-dependent manner. 20039427 2010
CUI: C0087031
Disease: Juvenile-Onset Still Disease
Juvenile-Onset Still Disease 		0.300 Biomarker disease CTD_human Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets. 19565504 2009
CUI: C3495559
Disease: Juvenile arthritis
Juvenile arthritis 		0.300 Biomarker disease CTD_human Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets. 19565504 2009
CUI: C3714758
Disease: Juvenile psoriatic arthritis
Juvenile psoriatic arthritis 		0.300 Biomarker disease CTD_human Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets. 19565504 2009
CUI: C4552091
Disease: Polyarthritis, Juvenile, Rheumatoid Factor Negative
Polyarthritis, Juvenile, Rheumatoid Factor Negative 		0.300 Biomarker disease CTD_human Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets. 19565504 2009
CUI: C4704862
Disease: Polyarthritis, Juvenile, Rheumatoid Factor Positive
Polyarthritis, Juvenile, Rheumatoid Factor Positive 		0.300 Biomarker disease CTD_human Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets. 19565504 2009
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 Biomarker disease MGD
CUI: C1800706
Disease: Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis 		0.210 Biomarker disease BEFREE Finally, Fra-2 and ColVI positively correlate in IPF patient samples and co-localize in lung macrophages. 31135379 2019