|
Colorectal Carcinoma
|
0.360 |
Biomarker
|
disease |
BEFREE |
In conclusion, we found no significant evidence that genetic variants in FOLR1, GGH, FPGS and SLC19A1 are associated with the risk of colorectal cancer.
|
20037791 |
2010 |
|
Colorectal Carcinoma
|
0.360 |
Biomarker
|
disease |
BEFREE |
In this study, primary tumors obtained from 1,129 patients with colorectal cancer were used to measure the mRNA expression levels of the following genes associated with the effects of standard chemotherapy for colorectal cancer: 5-fluorouracil (5-FU)-related thymidylate synthase (TYMS), dihydropyrimidine dehydrogenase (DPYD) and thymidine phosphorylase (TYMP); folate-related dihydrofolate reductase (DHFR), folylpolyglutamate synthase (FPGS) and gamma-glutamyl hydrolase (GGH); irinotecan-related topoisomerase I (TOP1); oxaliplatin-related excision repair cross-complementing 1 (ERCC1); biologic agent-related vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR).
|
26676887 |
2016 |
|
Colorectal Carcinoma
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
A multivariate logistic regression analysis revealed that high folylpolyglutamate synthase (FPGS) gene expression, low gamma-glutamyl hydrolase (GGH) gene expression and low ATP-binding cassette sub-family C, number 1 (ABCC1) gene expression in CRC tissues were predictive factors for a high reduced folate level after LV administration.
|
19636555 |
2010 |
|
Colorectal Carcinoma
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
Low gene expression of folylpolyglutamate synthase (FPGS) in colorectal mucosa correlates with low folate levels and poor survival of colorectal cancer (CRC) patients.
|
18418463 |
2008 |
|
Colorectal Carcinoma
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, we wanted to evaluate the interaction between MTHFR and thymidylate synthase (TS) and folylpolyglutamate synthase (FPGS) and to investigate the impact of folate concentration on patients with CRC with different MTHFR genotypes.
|
16512993 |
2006 |
|
Colorectal Carcinoma
|
0.360 |
Biomarker
|
disease |
BEFREE |
Real-time PCR was used to quantify expression levels of folate-associated genes including the reduced folate carrier (RFC-1), folylpolyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH),and thymidylate synthase (TS) in tumor tissue and adjacent mucosa of patients with primary colorectal cancer (n=102).
|
14676127 |
2003 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
We performed a mutation analysis in the coding regions of the FPGS gene and the association between single nucleotide polymorphisms (SNPs) within FPGS in a case-control sample of childhood ALL patients.
|
26107232 |
2015 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
To investigate the correlation between common genetic polymorphisms of folylpolyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH), and methylenetetrahydrofolate reductase (MTHFR) and serum levels of methotrexate (MTX) in Chinese children with acute lymphoblastic leukemia (ALL).
|
24908438 |
2014 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
We found significantly lower expression of the reduced folate carrier (SLC19A1, an MTX uptake transporter) in E2A-PBX1 ALL, significantly higher expression of breast cancer resistance protein (ABCG2, an MTX efflux transporter) in TEL-AML1 ALL, and lower expression of FPGS (which catalyzes formation of MTXPG) in T-lineage ALL, consistent with lower MTXPG accumulation in these ALL subtypes.
|
15630450 |
2005 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
There was a significant relationship between FPGS mRNA and enzyme activity in lymphoblasts from children with newly diagnosed ALL, and blast FPGS mRNA and activity increased after methotrexate treatment.
|
9224825 |
1997 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
Therefore, HDACI-induced FPGS expression increases the accumulation of MTX-PG(3-7) and cytotoxicity in ALL cell lines, which is potentiated by DHFR and TS downregulation.
|
20072153 |
2010 |
|
Rheumatoid Arthritis
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
FPGS and ABCB1 genetic variants can influence the outcome in RA patients receiving MTX monotherapy.
|
26652611 |
2016 |
|
Rheumatoid Arthritis
|
0.340 |
Biomarker
|
disease |
BEFREE |
FPGS may have a major role in regulating intracellular polyglutamation of MTX in RA patients receiving low-dose weekly MTX therapy.
|
27752107 |
2016 |
|
Rheumatoid Arthritis
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
Folyl polyglutamate synthethase (FPGS) gene polymorphisms may influence methotrexate adverse events in South Indian Tamil Rheumatoid Arthritis patients.
|
31611592 |
2020 |
|
Rheumatoid Arthritis
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
Exploratory analysis of four polymorphisms in human GGH and FPGS genes and their effect in methotrexate-treated rheumatoid arthritis patients.
|
17286537 |
2007 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Folylpoly-gamma-glutamate synthetase (FPGS) catalyzes the activation of folate antimetabolites in mammalian tissues and tumors.
|
10964921 |
2000 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Murine FPGS contains two AUG initiation codons, shown to be responsible for mitochondrial and cytosolic forms of the enzyme in human cells [2] Previous studies indicated species, tissue, and tumor specific differences in mammalian FPGS.
|
8605241 |
1996 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Gene expression of TS and FPGS were significantly higher in right-sided MSI-H tumors compared with right-sided MSS/MSI-L tumors (P < .0001, P = .041, respectively).
|
18039426 |
2007 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
FOLR1 and FPGS associated with tumor differentiation (both p<0.0001), spread to regional lymph nodes (FOLR1 p=0.0001 and FPGS p=0.0038), OS and PFS (FOLR1 p<0.0050 for both and FPGS p<0.0004 for OS).
|
27064343 |
2016 |
|
Neoplasms
|
0.060 |
GeneticVariation
|
group |
BEFREE |
Liver metastases (n = 93) along with primary tumors (n = 48) were analyzed for K-Ras mutations (codons 12 and 13), p53 mutations (exons 4-9), p53 polymorphism (codon 72), thymidylate synthase (TS) polymorphism (28-bp repeats including G>C mutation), methylenetetrahydrofolate reductase polymorphism (677C>T, 1298A>C), thymidylate synthase (TS) activity, dihydropyrimidine dehydrogenase activity, folylpolyglutamate synthase activity, and p53 protein expression.
|
18676755 |
2008 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Our results suggest that normal-appearing colonic mucosa adjacent to primary colon cancer can show altered gene expression levels of FPGS that may have bearing on the development of aggressive metastatic behavior of the tumor and on tumor-specific survival.
|
14676127 |
2003 |
|
Acute lymphocytic leukemia
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Therefore, HDACI-induced FPGS expression increases the accumulation of MTX-PG(3-7) and cytotoxicity in ALL cell lines, which is potentiated by DHFR and TS downregulation.
|
20072153 |
2010 |
|
Acute lymphocytic leukemia
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We found significantly lower expression of the reduced folate carrier (SLC19A1, an MTX uptake transporter) in E2A-PBX1 ALL, significantly higher expression of breast cancer resistance protein (ABCG2, an MTX efflux transporter) in TEL-AML1 ALL, and lower expression of FPGS (which catalyzes formation of MTXPG) in T-lineage ALL, consistent with lower MTXPG accumulation in these ALL subtypes.
|
15630450 |
2005 |
|
Acute lymphocytic leukemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
To investigate the correlation between common genetic polymorphisms of folylpolyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH), and methylenetetrahydrofolate reductase (MTHFR) and serum levels of methotrexate (MTX) in Chinese children with acute lymphoblastic leukemia (ALL).
|
24908438 |
2014 |
|
Acute lymphocytic leukemia
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
There was a significant relationship between FPGS mRNA and enzyme activity in lymphoblasts from children with newly diagnosed ALL, and blast FPGS mRNA and activity increased after methotrexate treatment.
|
9224825 |
1997 |