Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.010 GeneticVariation disease BEFREE ADMA, SDMA and L-arginine/ADMA ratio but not DDAH genetic polymorphisms are reliable predictors of diabetic nephropathy progression as identified by competing risk analysis. 23147199 2012
CUI: C0598608
Disease: Hyperhomocysteinemia
Hyperhomocysteinemia 		0.010 AlteredExpression disease BEFREE These results indicate that suppression of DDAH2 expression is a culprit for homocysteine-induced impairments of DDAH/ADMA/NOS/NO pathway in endothelial cells, and therapeutic manipulation of DDAH2 expression may be a promising strategy for preventing endothelial dysfunction and cardiovascular diseases associated with hyperhomocysteinemia. 23171931 2012
CUI: C0403447
Disease: Chronic Kidney Insufficiency
Chronic Kidney Insufficiency 		0.010 GeneticVariation disease BEFREE Starting from these findings, the study aims to investigate the role of DDAH2 gene promoter polymorphism at position -1151 A/C in determining the levels of ADMA in type 2 diabetic patients (T2DM) with chronic renal impairment. 23129820 2013
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.330 PosttranslationalModification disease BEFREE Hypermethylation of DDAH2 promoter contributes to the dysfunction of endothelial progenitor cells in coronary artery disease patients. 24934151 2014
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.330 PosttranslationalModification disease BEFREE DDAH2 promoter in EPCs from CAD patients was hypermethylated and the methylation level was negatively correlated to DDAH2 mRNA level and adhesion function of EPCs. 24934151 2014
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.040 GeneticVariation disease BEFREE To investigate determinants of asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), including single nucleotide polymorphisms (SNPs), in the DDAH1, DDAH2, and AGXT2 genes and their associations with prevalent and incident cardiovascular disease (CVD) in older adults with type 2 diabetes mellitus. 24186881 2014
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.030 GeneticVariation group BEFREE To investigate determinants of asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), including single nucleotide polymorphisms (SNPs), in the DDAH1, DDAH2, and AGXT2 genes and their associations with prevalent and incident cardiovascular disease (CVD) in older adults with type 2 diabetes mellitus. 24186881 2014
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.030 PosttranslationalModification disease BEFREE Hypermethylation of DDAH2 promoter contributes to the dysfunction of endothelial progenitor cells in coronary artery disease patients. 24934151 2014
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.020 GeneticVariation disease BEFREE Protective role of DDAH2 (rs805304) gene polymorphism in patients with myocardial infarction. 25236572 2014
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.010 PosttranslationalModification disease BEFREE Homocysteine disrupts EPCs function via inducing the hypermethylation of DDAH2 promoter, suggesting a key role of epigenetic mechanism in the progression of atherosclerosis. 24934151 2014
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.010 GeneticVariation disease BEFREE The results of our study give no evidence to suggest that increased ADMA levels in RA relate to DDAH genetic polymorphisms. 25194333 2014
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.010 PosttranslationalModification disease BEFREE Homocysteine disrupts EPCs function via inducing the hypermethylation of DDAH2 promoter, suggesting a key role of epigenetic mechanism in the progression of atherosclerosis. 24934151 2014
CUI: C0028754
Disease: Obesity
Obesity 		0.010 GeneticVariation disease BEFREE Under a recessive model adjusted for age and gender, the DDAH2 rs805304 C allele was associated with decreased risk of obesity (OR = 0.35, 95% CI = 0.22-0.57, P = 0.001). 25236572 2014
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.030 Biomarker group BEFREE We conducted a case-control study on a Chinese population that included three ethnic groups (Han, Kazakh and Uygur), to systemically investigate associations between variations in the genes DDAH1 and DDAH2 and hypertension. 26786611 2016
CUI: C0006287
Disease: Bronchopulmonary Dysplasia
Bronchopulmonary Dysplasia 		0.010 Biomarker disease BEFREE Clinical characteristics and 36 SNPs in DDAH1 and DDAH2 were compared between BPD-associated PH patients (cases) and BPD-alone patients (controls). 26663142 2016
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.040 Biomarker phenotype BEFREE Our previous study demonstrated that VPO1 plays a critical role in endothelial dysfunction through dimethylarginine dimethylaminohydrolase2 (DDAH2)/asymmetric Dimethylarginine (ADMA) pathway. 28264790 2017
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.010 Biomarker disease BEFREE Low-dose rosuvastatin exerted cardioprotective effects on isoproterenol-induced heart failure in rats by modulating DDAH-ADMA-NO pathway, and it may present the new therapeutic value in ameliorating chronic heart failure. 27957828 2017
CUI: C0264716
Disease: Chronic heart failure
Chronic heart failure 		0.010 Biomarker disease BEFREE Low-dose rosuvastatin exerted cardioprotective effects on isoproterenol-induced heart failure in rats by modulating DDAH-ADMA-NO pathway, and it may present the new therapeutic value in ameliorating chronic heart failure. 27957828 2017
CUI: C1328504
Disease: Hormone refractory prostate cancer
Hormone refractory prostate cancer 		0.010 Biomarker disease BEFREE Here, we discovered a fundamental role of S-phase protein kinase 2 (Skp2) in the formation and progression of CRPC. 28346424 2017
CUI: C0036690
Disease: Septicemia
Septicemia 		0.020 GeneticVariation disease BEFREE Pilot studies have associated the rs805305 SNP of DDAH2 with ADMA concentrations in sepsis. 30538005 2018
CUI: C0243026
Disease: Sepsis
Sepsis 		0.020 GeneticVariation disease BEFREE Pilot studies have associated the rs805305 SNP of DDAH2 with ADMA concentrations in sepsis. 30538005 2018
CUI: C0014179
Disease: Endometritis
Endometritis 		0.010 Biomarker disease BEFREE The present findings suggest that elevated levels of ADMA are associated with lower DDAH2 and higher PRMT1 in LPS-induced endometritis rat. 29119338 2018
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.330 GeneticVariation disease BEFREE The functional variant rs9267551 C, in the promoter region of DDAH2, has been linked to increased DDAH2 expression, and lower ADMA plasma levels, and was associated with lower risk of coronary artery disease in large-scale genome-wide association studies (GWAS) performed in the general population. 31409409 2019
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.330 GeneticVariation disease BEFREE The functional variant rs9267551 C, in the promoter region of DDAH2, has been linked to increased DDAH2 expression, and lower ADMA plasma levels, and was associated with lower risk of coronary artery disease in large-scale genome-wide association studies (GWAS) performed in the general population. 31409409 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.030 GeneticVariation disease BEFREE The functional variant rs9267551 C, in the promoter region of DDAH2, has been linked to increased DDAH2 expression, and lower ADMA plasma levels, and was associated with lower risk of coronary artery disease in large-scale genome-wide association studies (GWAS) performed in the general population. 31409409 2019