FPR1, formyl peptide receptor 1, 2357

N. diseases: 93; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0014060
Disease: Encephalitis, St. Louis
Encephalitis, St. Louis 		0.010 AlteredExpression disease BEFREE On the other hand, CR1 levels of PMN stimulated by FMLP were also found to be decreased in SLE patients, while both the expression of circulating PMN (cells isolated at 4 degrees C) and the total cellular CR1 content were normal. 2974768 1988
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.010 AlteredExpression disease BEFREE On the other hand, CR1 levels of PMN stimulated by FMLP were also found to be decreased in SLE patients, while both the expression of circulating PMN (cells isolated at 4 degrees C) and the total cellular CR1 content were normal. 2974768 1988
CUI: C0949691
Disease: Spondylarthropathies
Spondylarthropathies 		0.010 AlteredExpression group BEFREE We assessed the expression of complement receptors (CR1 and CR3) and Fc gamma RIII on unstimulated and FMLP activated polymorphonuclears (PMNs) by indirect immunofluorescence and flow cytometry using CD35 (CR1), CD11b (CR3) and CD16 (Fc gamma RIII) monoclonal antibodies in 24 patients with spondylarthropathies (SpA) and in 18 healthy subjects. 8453794 1993
CUI: C0031106
Disease: Aggressive Periodontitis
Aggressive Periodontitis 		0.060 GeneticVariation disease BEFREE In order to determine if this decreased response is due to a genetic variation in the receptor, we directly compared DNA encoding the FMLP receptor from controls matched for gender and race and LJP patients by single-strand conformation polymorphism analysis (SSCP). 10534074 1999
CUI: C0002726
Disease: Amyloidosis
Amyloidosis 		0.010 Biomarker disease BEFREE Amyloid (beta)42 activates a G-protein-coupled chemoattractant receptor, FPR-like-1. 11160457 2001
CUI: C0031106
Disease: Aggressive Periodontitis
Aggressive Periodontitis 		0.060 GeneticVariation disease BEFREE These data do not support the hypothesis that the FPR1 SNPs c.329T>C and c.378C>G play an etiologic role in aggressive periodontitis, but do suggest that SNPs in the second extracellular loop may be etiologically important. 12595898 2003
CUI: C0001342
Disease: Acute periodontitis
Acute periodontitis 		0.040 GeneticVariation disease BEFREE These data do not support the hypothesis that the FPR1 SNPs c.329T>C and c.378C>G play an etiologic role in aggressive periodontitis, but do suggest that SNPs in the second extracellular loop may be etiologically important. 12595898 2003
CUI: C0031106
Disease: Aggressive Periodontitis
Aggressive Periodontitis 		0.060 GeneticVariation disease BEFREE To determine whether the recently identified FPR mutations in LJP patients are responsible for selective loss of receptor-mediated functions, we prepared and analyzed RBL-2H3 cells expressing FPR bearing Phe110 to Ser (FPR-F110S) or Cys-126 to Trp (FPR-C126W) replacement as well as a FPR double mutant (FPR-FSCW). 15195697 2004
CUI: C0017638
Disease: Glioma
Glioma 		0.030 AlteredExpression disease LHGDN FPR protein expression was detected in specimens from 33 human primary gliomas by immunohistochemistry. 15928303 2005
CUI: C0031106
Disease: Aggressive Periodontitis
Aggressive Periodontitis 		0.060 GeneticVariation disease BEFREE Thus, altered FPR1 function might confer increased risk to AgP. 17927965 2007
CUI: C0001342
Disease: Acute periodontitis
Acute periodontitis 		0.040 GeneticVariation disease BEFREE Thus, altered FPR1 function might confer increased risk to AgP. 17927965 2007
CUI: C0017638
Disease: Glioma
Glioma 		0.030 AlteredExpression disease BEFREE Our results indicate that FPR expressed by human GSCs may play an important role in glioma angiogenesis. 18523971 2008
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.010 GeneticVariation disease BEFREE We also investigated whether certain FPR haplotypes are associated with rheumatoid arthritis (RA) by sequencing FPR1 from 148 Caucasian individuals. 18253729 2008
CUI: C0031106
Disease: Aggressive Periodontitis
Aggressive Periodontitis 		0.060 GeneticVariation disease BEFREE Previous work revealed a significant association between FPR1 single nucleotide polymorphism (SNP) 348T>C and AgP in African Americans. 19722801 2009
CUI: C0031106
Disease: Aggressive Periodontitis
Aggressive Periodontitis 		0.060 GeneticVariation disease BEFREE The objective of this study was to determine whether single nucleotide polymorphisms (SNPs) in FPR1 are associated with AgP. 19254133 2009
CUI: C0001342
Disease: Acute periodontitis
Acute periodontitis 		0.040 GeneticVariation disease BEFREE Previous work revealed a significant association between FPR1 single nucleotide polymorphism (SNP) 348T>C and AgP in African Americans. 19722801 2009
CUI: C0001342
Disease: Acute periodontitis
Acute periodontitis 		0.040 GeneticVariation disease BEFREE The objective of this study was to determine whether single nucleotide polymorphisms (SNPs) in FPR1 are associated with AgP. 19254133 2009
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.030 AlteredExpression disease LHGDN Furthermore, Aza treatment or overexpression of the wild-type p53 in glioblastoma cells increased the binding of p53 to FPR promoter region shown by chromatin immunoprecipitation. 19037090 2009
CUI: C0017638
Disease: Glioma
Glioma 		0.030 AlteredExpression disease BEFREE Our results suggest that expression of functional FPR in glioma cells plays an important role in regulating vasculogenesis by EPCs, which constitute a novel target for anti-angiogenic therapy in gliomas. 20933627 2010
CUI: C0031099
Disease: Periodontitis
Periodontitis 		0.310 Biomarker disease BEFREE To date, little is known about the relationships between FPR1 and such diseases, aside from the fact that FPR1 is related to periodontitis, which is implicated in systemic diseases such as stomach cancer. 21216225 2011
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.030 GeneticVariation disease BEFREE This is the first study to evaluate polymorphisms of the FPR1 gene in stomach cancer to find a positive association between these polymorphisms and stomach cancer. 21216225 2011
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.030 GeneticVariation disease BEFREE This is the first study to evaluate polymorphisms of the FPR1 gene in stomach cancer to find a positive association between these polymorphisms and stomach cancer. 21216225 2011
CUI: C0031090
Disease: Periodontal Diseases
Periodontal Diseases 		0.010 GeneticVariation group BEFREE We hypothesized that FPR1 polymorphisms related to periodontal disease may confer susceptibility to stomach cancer. 21216225 2011
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.010 AlteredExpression group BEFREE These observations suggest a novel signaling role for ANXA1 in mitogen-activated proliferation of breast tumor epithelial cells that is mediated via activation of FPR1 and FPR2. 20930115 2011
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.010 GeneticVariation group BEFREE Therefore, the relationship between FPR1 C32T SNP, BP and hypertension needs to be investigated. 21144844 2012