|
Periodontitis
|
0.310 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Genetic polymorphisms and periodontal disease in populations of African descent: A review.
|
29105764 |
2018 |
|
Periodontitis
|
0.310 |
Biomarker
|
disease |
BEFREE |
To date, little is known about the relationships between FPR1 and such diseases, aside from the fact that FPR1 is related to periodontitis, which is implicated in systemic diseases such as stomach cancer.
|
21216225 |
2011 |
|
Anxiety
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.
|
29942085 |
2018 |
|
High density lipoprotein measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
|
30275531 |
2018 |
|
Aggressive Periodontitis
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Previous work revealed a significant association between FPR1 single nucleotide polymorphism (SNP) 348T>C and AgP in African Americans.
|
19722801 |
2009 |
|
Aggressive Periodontitis
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study was to determine whether single nucleotide polymorphisms (SNPs) in FPR1 are associated with AgP.
|
19254133 |
2009 |
|
Aggressive Periodontitis
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Thus, altered FPR1 function might confer increased risk to AgP.
|
17927965 |
2007 |
|
Aggressive Periodontitis
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
To determine whether the recently identified FPR mutations in LJP patients are responsible for selective loss of receptor-mediated functions, we prepared and analyzed RBL-2H3 cells expressing FPR bearing Phe110 to Ser (FPR-F110S) or Cys-126 to Trp (FPR-C126W) replacement as well as a FPR double mutant (FPR-FSCW).
|
15195697 |
2004 |
|
Aggressive Periodontitis
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
These data do not support the hypothesis that the FPR1 SNPs c.329T>C and c.378C>G play an etiologic role in aggressive periodontitis, but do suggest that SNPs in the second extracellular loop may be etiologically important.
|
12595898 |
2003 |
|
Aggressive Periodontitis
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
In order to determine if this decreased response is due to a genetic variation in the receptor, we directly compared DNA encoding the FMLP receptor from controls matched for gender and race and LJP patients by single-strand conformation polymorphism analysis (SSCP).
|
10534074 |
1999 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Also, there was reduced expression of ANXA1 and FPR1 in esophageal carcinoma but COX-2 overexpression in this tumor.
|
29254791 |
2018 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Following FPR1 silencing in SiHa cells using lentiviral siRNA delivery, biological characteristics and tumor formation were evaluated in vitro and in vivo, respectively.
|
30510453 |
2018 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
FPR1 mRNA expression was also associated with tumor serosal infiltration.
|
28724995 |
2017 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Stimulation of FPR1 in neuroblastoma cells using fMLP, a selective FPR1 agonist, induced intracellular calcium mobilization and activation of MAPK/Erk, PI3K/Akt and P38-MAPK signal transduction pathways that were inhibited by using Cyclosporin H, a selective receptor antagonist for FPR1. shRNA knock-down of FPR1 in neuroblastoma cells conferred a delayed xenograft tumor development in nude mice, whereas an ectopic overexpression of FPR1 promoted augmented tumorigenesis in nude mice.
|
27432059 |
2016 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
The formyl peptide receptor 1 exerts a tumor suppressor function in human gastric cancer by inhibiting angiogenesis.
|
25263443 |
2015 |
|
Acute periodontitis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Previous work revealed a significant association between FPR1 single nucleotide polymorphism (SNP) 348T>C and AgP in African Americans.
|
19722801 |
2009 |
|
Acute periodontitis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study was to determine whether single nucleotide polymorphisms (SNPs) in FPR1 are associated with AgP.
|
19254133 |
2009 |
|
Acute periodontitis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Thus, altered FPR1 function might confer increased risk to AgP.
|
17927965 |
2007 |
|
Acute periodontitis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
These data do not support the hypothesis that the FPR1 SNPs c.329T>C and c.378C>G play an etiologic role in aggressive periodontitis, but do suggest that SNPs in the second extracellular loop may be etiologically important.
|
12595898 |
2003 |
|
Malignant Neoplasms
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Furthermore, plague selection of FPR1 alleles appears to have shaped human immune responses towards other infectious diseases and malignant neoplasms.
|
31534221 |
2019 |
|
Malignant tumor of cervix
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In this study, we developed a novel immunotherapeutic peptide by linking the <i>Mycobacterium tuberculosis</i> (MTB) heat shock protein 70 (Hsp70) functional peptide to the extracellular domain of FPR1, a protein overexpressed in cervical cancer, to obtain an MTBHsp70-exFPR1 fusion protein.
|
31772669 |
2019 |
|
Cervix carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In this study, we developed a novel immunotherapeutic peptide by linking the <i>Mycobacterium tuberculosis</i> (MTB) heat shock protein 70 (Hsp70) functional peptide to the extracellular domain of FPR1, a protein overexpressed in cervical cancer, to obtain an MTBHsp70-exFPR1 fusion protein.
|
31772669 |
2019 |
|
cervical cancer
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In this study, we developed a novel immunotherapeutic peptide by linking the <i>Mycobacterium tuberculosis</i> (MTB) heat shock protein 70 (Hsp70) functional peptide to the extracellular domain of FPR1, a protein overexpressed in cervical cancer, to obtain an MTBHsp70-exFPR1 fusion protein.
|
31772669 |
2019 |
|
Malignant tumor of cervix
|
0.030 |
Biomarker
|
disease |
BEFREE |
The excellent capability of MtHSP70-FPR1 fusion protein to induce phenotypical and functional maturation of moDCs and CC-specific CTL responses partly illustrates the potential clinical benefits of DC-based immunotherapy for CC.
|
30098789 |
2018 |
|
Malignant tumor of cervix
|
0.030 |
Biomarker
|
disease |
BEFREE |
FPR1 activation induced NF-κB nuclear translocation to promote cervical cancer development through the upregulation of IL-6 and IL-8 expression.
|
30510453 |
2018 |