Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011847
Disease: Diabetes
Diabetes
0.030 Biomarker disease BEFREE Streptozotocin (STZ) was used to induce diabetes in adult DDAH1 knock-out and wild type mice.Healthy mice served as controls. 31818438 2019
CUI: C0011847
Disease: Diabetes
Diabetes
0.030 Biomarker disease BEFREE Our data demonstrated that inducible nitric oxide synthase/gamma-Glutamyl-cysteine ligase (iNOS/GGCL) and DDAH dysregulation may play a key role in high glucose mediated oxidative stress, whereas HO-1 inducers such as CAPE or its more potent derivatives may be useful in diabetes and other stress-induced pathological conditions. 31108850 2019
CUI: C0011847
Disease: Diabetes
Diabetes
0.030 Biomarker disease BEFREE Innovation and Conclusion: Our results provide the first direct evidence that the DDAH1 has a marked effect on kidney fibrosis and oxidative stress induced by aging or diabetes. 28594240 2017