|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Upon virus infection, LRRC59 specifically interacted with ISG15-associated DDX58 and blocked its association with LRRC25, the secondary receptor to deliver DDX58 to autophagosomes for SQSTM1/p62-dependent degradation, leading to the stronger antiviral immune responses.
|
31068071 |
2020 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Two cytosolic RIG-like RNA helicases, RIG-I and MDA5, are key to type I interferon (IFN) induction in response to viral infection.
|
26939124 |
2016 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest that PACT plays an important role in potentiating RIG-I function to produce type I IFNs in order to restrict arenavirus replication and that viral NP RNase activity is essential for optimal viral replication by suppressing PACT-induced RIG-I activation.<b>IMPORTANCE</b> We report here a new role of the nucleoproteins of arenaviruses that can block type I IFN production via their specific inhibition of the cellular protein sensors of virus infection (RIG-I and PACT).
|
29669840 |
2018 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Specifically, we demonstrate that DRH-1/RIG-I is required for inducing the IPR in response to Orsay virus infection, but not in response to other triggers like microsporidian infection or proteotoxic stress.
|
31619561 |
2020 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
RIG-I Activation by a Designer Short RNA Ligand Protects Human Immune Cells against Dengue Virus Infection without Causing Cytotoxicity.
|
31043531 |
2019 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
We found that intracellular poly(I·C) transfection to mimic viral infection enhances the RIG-I/MDA5 (melanoma differentiation-associated gene 5)-mediated dimerization of interferon regulatory factor 3 (IRF-3).
|
29496994 |
2018 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of the pathogen-associated molecular patterns (PAMPs) in the form of viral double-stranded RNA (dsRNA) motifs to induce expression of type 1 interferons (IFN1) (IFNα and IFNβ) and other pro-inflammatory cytokines during the early stage of viral infection.
|
31379819 |
2019 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The use of a human cell line expressing a debilitated RIG-I molecule, together with overexpression studies of wild type RIG-I, showed that the IFN-beta induction by virus infection or by leader RNA required RIG-I to be functional.
|
17356690 |
2007 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
RIG-I-like receptor regulation in virus infection and immunity.
|
25644461 |
2015 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
RIG-I-like receptors detect viral RNA in infected cells and promote oligomerization of the outer mitochondrial membrane protein MAVS to induce innate immunity to viral infection through type I interferon production.
|
26317833 |
2015 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Apart from TLRs, other PRRs such as RIG-1 and MDA-5 are also able to recognize viral infection and participate in the activation of type I interferon synthesis.
|
20533094 |
2010 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
RIG-I is a cytoplasmic viral RNA sensor that triggers the signal to induce type I interferon production in response to viral infection.
|
23950712 |
2013 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Compared with H1N1 virus-induced mediators, H5N1 mediators markedly enhance the cytokine response to PolyIC and to both seasonal and H5N1 virus infection in a RIG-I-dependent manner.
|
22013225 |
2011 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Virus infection is sensed in the cytoplasm by retinoic acid-inducible gene I (RIG-I, also known as DDX58), which requires RNA and polyubiquitin binding to induce type I interferon (IFN) and activate cellular innate immunity.
|
24931123 |
2014 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
RIG-I-like receptors (RLRs: RIG-I, MDA5 and LGP2) play a major role in the innate immune response against viral infections and detect patterns on viral RNA molecules that are typically absent from host RNA.
|
24743923 |
2014 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
RIG-I-like receptors and Toll-like receptors (TLRs) play important roles in the recognition of viral infections.
|
22072781 |
2012 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The RIG-I-like receptor (RLR) family of pattern recognition receptors (PRRs) is a group of cytosolic RNA helicase proteins that can identify viral RNA as nonself via binding to pathogen associated molecular patter (PAMP) motifs within RNA ligands that accumulate during virus infection.
|
21949557 |
2011 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
TRAF3 appears to undergo sequential ubiquitin "immuno-editing" following virus infection that is crucial for regulation of RIG-I-dependent signaling to the antiviral response.
|
19893624 |
2009 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Mechanistically, Lnczc3h7a binds to both TRIM25 and activated RIG-I, serving as a molecular scaffold for stabilization of the RIG-I-TRIM25 complex at the early stage of viral infection.
|
31036902 |
2019 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Defective RNA sensing by RIG-I in severe influenza virus infection.
|
29453856 |
2018 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Neuronal transcriptomic responses to Japanese encephalitis virus infection with a special focus on chemokine CXCL11 and pattern recognition receptors RIG-1 and MDA5.
|
30481615 |
2019 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
RIG-I is a cytosolic RNA sensor that recognizes short 5' triphosphate RNA, commonly generated during virus infection.
|
31463653 |
2019 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Sumoylation of the caspase recruitment domains of MDA5 and RIG-I is also required for their dephosphorylation by PP1 and activation upon viral infection.
|
28250012 |
2017 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Resolving influenza infection in mammals has been shown to require RIG-I; however, the apparent absence of a RIG-I homolog in chickens raises intriguing questions regarding how this species deals with influenza virus infection.
|
21444763 |
2011 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IRF-3 depletion was dependent on a productive HIV-1 replication cycle and caused the specific disruption of Toll-like receptor and RIG-I-like receptor innate immune signaling that rendered cells permissive to secondary virus infection.
|
19706707 |
2009 |