DDX58, DExD/H-box helicase 58, 23586

N. diseases: 144; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE The use of a human cell line expressing a debilitated RIG-I molecule, together with overexpression studies of wild type RIG-I, showed that the IFN-beta induction by virus infection or by leader RNA required RIG-I to be functional. 17356690 2007
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE RIG-I and MDA5 are cytoplasmic DEX(D/H) helicase proteins that can induce signaling in response to RNA ligands, including those from viral infections. 18411269 2008
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE IRF-3 depletion was dependent on a productive HIV-1 replication cycle and caused the specific disruption of Toll-like receptor and RIG-I-like receptor innate immune signaling that rendered cells permissive to secondary virus infection. 19706707 2009
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE TRAF3 appears to undergo sequential ubiquitin "immuno-editing" following virus infection that is crucial for regulation of RIG-I-dependent signaling to the antiviral response. 19893624 2009
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE Apart from TLRs, other PRRs such as RIG-1 and MDA-5 are also able to recognize viral infection and participate in the activation of type I interferon synthesis. 20533094 2010
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 AlteredExpression group BEFREE RIG-I-like receptors (RLRs) are expressed ubiquitously at low levels, and their expression is induced by treatment with type I interferon (IFN) or a viral infection. 20950133 2011
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE The relative roles of the endosomal TLR3/7/8 versus the intracellular RNA helicases RIG-I and MDA5 in viral infection is much debated. 21079690 2010
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE Resolving influenza infection in mammals has been shown to require RIG-I; however, the apparent absence of a RIG-I homolog in chickens raises intriguing questions regarding how this species deals with influenza virus infection. 21444763 2011
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE The RIG-I-like receptor (RLR) family of pattern recognition receptors (PRRs) is a group of cytosolic RNA helicase proteins that can identify viral RNA as nonself via binding to pathogen associated molecular patter (PAMP) motifs within RNA ligands that accumulate during virus infection. 21949557 2011
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE Compared with H1N1 virus-induced mediators, H5N1 mediators markedly enhance the cytokine response to PolyIC and to both seasonal and H5N1 virus infection in a RIG-I-dependent manner. 22013225 2011
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE RIG-I-like receptors and Toll-like receptors (TLRs) play important roles in the recognition of viral infections. 22072781 2012
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE Goose RIG-I functions in innate immunity against Newcastle disease virus infections. 23063767 2013
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE RIG-I is a cytoplasmic viral RNA sensor that triggers the signal to induce type I interferon production in response to viral infection. 23950712 2013
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE RIG-I-like receptors (RLRs: RIG-I, MDA5 and LGP2) play a major role in the innate immune response against viral infections and detect patterns on viral RNA molecules that are typically absent from host RNA. 24743923 2014
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE This is critical for promoting the growth and survival of T lymphocytes as well as the regulation of the RIG-I helicase pathway for type I interferon production in response to viral infections. 24816846 2014
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE Virus infection is sensed in the cytoplasm by retinoic acid-inducible gene I (RIG-I, also known as DDX58), which requires RNA and polyubiquitin binding to induce type I interferon (IFN) and activate cellular innate immunity. 24931123 2014
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE RIG-I-like receptor regulation in virus infection and immunity. 25644461 2015
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE RIG-I-like receptors detect viral RNA in infected cells and promote oligomerization of the outer mitochondrial membrane protein MAVS to induce innate immunity to viral infection through type I interferon production. 26317833 2015
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE Two cytosolic RIG-like RNA helicases, RIG-I and MDA5, are key to type I interferon (IFN) induction in response to viral infection. 26939124 2016
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE Sumoylation of the caspase recruitment domains of MDA5 and RIG-I is also required for their dephosphorylation by PP1 and activation upon viral infection. 28250012 2017
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE RIG-I Activation Protects and Rescues from Lethal Influenza Virus Infection and Bacterial Superinfection. 28760668 2017
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE The RNA binding protein La/SS-B promotes RIG-I-mediated type I and type III IFN responses following Sendai viral infection. 29109527 2017
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE A recent study found that the delivery of circRNAs generated <i>in vitro</i> activates RIG-I-mediated innate immune responses and provides protection against viral infection. 29230098 2017
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE Defective RNA sensing by RIG-I in severe influenza virus infection. 29453856 2018
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE We found that intracellular poly(I·C) transfection to mimic viral infection enhances the RIG-I/MDA5 (melanoma differentiation-associated gene 5)-mediated dimerization of interferon regulatory factor 3 (IRF-3). 29496994 2018