DDX58, DExD/H-box helicase 58, 23586

N. diseases: 144; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.010 AlteredExpression disease BEFREE High RIG-I expression in ovarian cancer associates with an immune-escape signature and poor clinical outcome. 31800094 2020
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.010 AlteredExpression disease BEFREE High RIG-I expression in ovarian cancer associates with an immune-escape signature and poor clinical outcome. 31800094 2020
CUI: C4721610
Disease: Carcinoma, Ovarian Epithelial
Carcinoma, Ovarian Epithelial 		0.010 AlteredExpression disease BEFREE High RIG-I expression in ovarian cancer associates with an immune-escape signature and poor clinical outcome. 31800094 2020
CUI: C0008495
Disease: Chorioamnionitis
Chorioamnionitis 		0.010 Biomarker phenotype BEFREE Interestingly, STING, RIG-I, and TLR3 are all involved in viral response pathways, suggesting that fetuses exposed to chorioamnionitis or fetal inflammatory reaction might respond differently to viruses postnatally. 31421529 2019
CUI: C0024312
Disease: Lymphopenia
Lymphopenia 		0.010 Biomarker disease BEFREE The RIG-I pathway is involved in peripheral T cell lymphopenia in patients with dermatomyositis. 31142372 2019
CUI: C0025205
Disease: Melanoma, Experimental
Melanoma, Experimental 		0.010 Biomarker disease BEFREE Overall, our data demonstrate the potency of a novel combinatorial vaccination strategy combining RIG-I-driven immunization with CTLA-4 blockade to prevent and treat experimental melanoma. 30852164 2019
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.010 Biomarker disease BEFREE Nanoparticle Delivery of RIG-I Agonist Enables Effective and Safe Adjuvant Therapy in Pancreatic Cancer. 30545600 2019
CUI: C0266999
Disease: Vesicular Stomatitis
Vesicular Stomatitis 		0.010 AlteredExpression disease BEFREE Vesicular stomatitis virus (VSV) infection downregulates NLRP12 expression to allow RIG-I activation. 30902577 2019
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.010 Biomarker disease BEFREE Nanoparticle Delivery of RIG-I Agonist Enables Effective and Safe Adjuvant Therapy in Pancreatic Cancer. 30545600 2019
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.010 AlteredExpression disease BEFREE Identification of the first endogenous mammalian microRNA that binds to RIG-I inducing IFN production but also demonstrate a novel pathophysiological underlying mechanism in which miR-1248 overexpression links two major pathways associated with SS, namely activation of IFN production with modulation of calcium signaling. 31597594 2019
CUI: C1561643
Disease: Chronic Kidney Diseases
Chronic Kidney Diseases 		0.010 Biomarker group BEFREE The findings suggest that Klotho can suppress CKD-associated systemic inflammation through inhibiting IS-induced RIG-1/NF-κB activation and monocyte inflammatory factor release. 31207307 2019
CUI: C1840264
Disease: IMMUNE SUPPRESSION
IMMUNE SUPPRESSION 		0.010 Biomarker phenotype BEFREE We review related studies on mouse Adar1 mutant phenotypes, their rescues by preventing signaling from the antiviral RIG-I-like Sensors (RLRs), as well as Adar1 mechanisms in innate immune suppression and other roles of Adar1, including editing-independent effects. 30391332 2019
CUI: C1861453
Disease: Pseudohyperkalemia Cardiff
Pseudohyperkalemia Cardiff 		0.010 GeneticVariation disease BEFREE IFIH1 rs3747517 (dominant model: Adjusted odds ratio [OR] = 1.34, 95% confidence interval [CI] = 1.07-1.68; P = 0.009) and DDX58 rs9695310 (dominant model: Adjusted OR = 1.43, 95% CI = 1.15-1.78; P = 0.001) were associated with chronic hepatitis C (CHC). 30633820 2019
CUI: C3264382
Disease: Swine influenza virus (viruses that normally cause infections in pigs)
Swine influenza virus (viruses that normally cause infections in pigs) 		0.010 GeneticVariation disease BEFREE Knockdown of RIG-I dramatically impaired the induction of IFN-β and ISG56 in NS1 Y73F or S83A mutant-infected cells, indicating that RIG-I plays a role in the IFN-β response upon rSIV NS1 Y73F and rSIV NS1 S83A infection. 31805964 2019
CUI: C3694279
Disease: Middle East Respiratory Syndrome
Middle East Respiratory Syndrome 		0.010 Biomarker disease BEFREE Middle East Respiratory Syndrome Coronavirus-Encoded ORF8b Inhibits RIG-I-Like Receptors in a Differential Mechanism. 31838791 2019
CUI: C0004096
Disease: Asthma
Asthma 		0.010 Biomarker disease BEFREE PI3Kδ contributes to ER stress-associated asthma through ER-redox disturbances: the involvement of the RIDD-RIG-I-NF-κB axis. 29504610 2018
CUI: C0018572
Disease: Hand, Foot and Mouth Disease
Hand, Foot and Mouth Disease 		0.010 GeneticVariation disease BEFREE The results indicated that RIG-1 (rs3739674 and rs9695310) polymorphisms are associated with an increased risk of EV71-induced HFMD in Chinese children, whereas RIG-1 rs3739674 and TLR3 rs5743305 polymorphisms are associated with disease severity. 29235129 2018
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.010 Biomarker disease BEFREE Knockdown of RIG-I was achieved by RNAi technology to examine the contribution of RIG-I in the regulation of biological functions in the cell lines of human gastric cancer. 30250402 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.010 Biomarker phenotype BEFREE Importantly, RIG-I activation in breast tumors increased tumor lymphocytes and decreased tumor growth and metastasis. 30224377 2018
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.010 Biomarker disease BEFREE This study is conducted to evaluate the role of RIG-I and its adaptor protein MAVS in the pathogenesis of osteoarthritis. 29392080 2018
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma 		0.010 Biomarker disease BEFREE RIG-I Detects Kaposi's Sarcoma-Associated Herpesvirus Transcripts in a RNA Polymerase III-Independent Manner. 29970461 2018
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.010 AlteredExpression disease BEFREE The DDX58 messenger RNA expression was higher in blood of patients with AAA compared with healthy subjects (P = .021). 29567028 2018
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.010 Biomarker disease BEFREE Knockdown of RIG-I was achieved by RNAi technology to examine the contribution of RIG-I in the regulation of biological functions in the cell lines of human gastric cancer. 30250402 2018
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.010 Biomarker group BEFREE Importantly, RIG-I activation in breast tumors increased tumor lymphocytes and decreased tumor growth and metastasis. 30224377 2018
CUI: C0001883
Disease: Airway Obstruction
Airway Obstruction 		0.010 AlteredExpression group BEFREE Similarly, BRD4 inhibition reduces RSV-induced neutrophilia, mucosal CXC chemokine expression, activation of the IRF7-RIG-I autoamplification loop, mucosal IFN expression, and airway obstruction. 28077651 2017