DDX58, DExD/H-box helicase 58, 23586

N. diseases: 144; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025007
Disease: Measles
Measles
0.040 GeneticVariation disease BEFREE An intronic SNP (rs669260) in the antiviral innate immune receptor gene, DDX58, was significantly associated with increased neutralizing antibody titers for both measles and rubella viral antigens post-MMR vaccination (p values 0.02 and 0.0002, respectively). 25139337 2014
CUI: C0025007
Disease: Measles
Measles
0.040 GeneticVariation disease BEFREE Genetic variants within the DDX58/RIG-I gene, including a coding polymorphism (rs3205166/Val800Val), were associated as single-SNPs (p≤0.017; although these SNPs did not remain significant after correction for false discovery rate/FDR) and in haplotype-level analysis, with measles-specific antibody variations in Caucasians (haplotype allele p-value=0.021; haplotype global p-value=0.076). 21939710 2011
CUI: C0025007
Disease: Measles
Measles
0.040 Biomarker disease BEFREE Genetic variation in key innate pathogen recognition receptors, such as the measles cell entry receptors CD46 and SLAM, measles attachment receptor DC-SIGN, the antiviral toll-like receptors (TLR)3, TLR7 and TLR8, and the cytosolic antiviral receptor RIG-I, may significantly affect measles IgG antibody responses. 22871352 2012
CUI: C0025007
Disease: Measles
Measles
0.040 AlteredExpression disease BEFREE Our findings suggest that RIG-I and MDA5 associate with AU-rich RNA species originating from the mRNA of the measles virus L gene. 24743923 2014