DDX58, DExD/H-box helicase 58, 23586

N. diseases: 144; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011311
Disease: Dengue Fever
Dengue Fever
0.060 Biomarker disease BEFREE RIG-I Activation by a Designer Short RNA Ligand Protects Human Immune Cells against Dengue Virus Infection without Causing Cytotoxicity. 31043531 2019
CUI: C0011311
Disease: Dengue Fever
Dengue Fever
0.060 Biomarker disease BEFREE We here show that dengue virus (DENV) infection of human dendritic cells (DCs) drives TFH formation via crosstalk of RIG-I-like receptor (RLR) RIG-I and MDA5 with type I Interferon (IFN) signaling. 29186193 2017
CUI: C0011311
Disease: Dengue Fever
Dengue Fever
0.060 Biomarker disease BEFREE In primary human monocytes and monocyte-derived dendritic cells, the RIG-I agonist blocked both primary infection and antibody-dependent enhancement of DENV infection. 24478443 2014
CUI: C0011311
Disease: Dengue Fever
Dengue Fever
0.060 AlteredExpression disease BEFREE In contrast to normal DENV infections, with ADE in DENV infections, inhibition of STAT1 phosphorylation and a reduction in IRF-1 gene expression, NOS2 levels, and RIG-1 and MDA-5 expression levels occurs. 29740424 2018
CUI: C0011311
Disease: Dengue Fever
Dengue Fever
0.060 Biomarker disease BEFREE An affinity purification method combined with next-generation sequencing (NGS) revealed that the 5' region of the DENV genome is recognized by RIG-I.No DENV RNA was bound to MDA5. 29996094 2018
CUI: C0011311
Disease: Dengue Fever
Dengue Fever
0.060 GeneticVariation disease BEFREE The results revealed a lower carrier frequency of the DDX58 rs3205166 G allele in DEN than in HCs and a higher frequency of the DDX58 rs669260 T/C genotype in DHF than in DF cases (P = 0.043, OR with 95 % CI 3.358 [1.038-10.861]). 25850761 2015