DDX58, DExD/H-box helicase 58, 23586
N. diseases: 144; N. variants: 10
Source: ALL
Disease | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year |
---|---|---|---|---|---|---|---|
|
0.060 | AlteredExpression | disease | BEFREE | Stimulation with RSV or Poly(I:C) induced IFN-β expression, which resulted in an increased expression of the viral receptors TLR3 and RIG-I, as well as an increased NOD2 expression. | 22730064 | 2012 |
|
0.060 | Biomarker | disease | BEFREE | Attenuation of respiratory syncytial virus-induced and RIG-I-dependent type I IFN responses in human neonates and very young children. | 24391215 | 2014 |
|
0.060 | Biomarker | disease | BEFREE | Inhibition of BRD4 blocks Toll-like receptor 3 (TLR3)-dependent neutrophilia and RSV-induced inflammation, demonstrating its importance in the mucosal innate response <i>in vivo</i> Our study shows that BRD4 plays a central role in inflammation and activation of the IRF7-RIG-I amplification loop vital for mucosal interferon expression. | 28077651 | 2017 |
|
0.060 | AlteredExpression | disease | BEFREE | Western blot analyses further revealed that 4(3H)-Quinazolone inhibited RSV-induced expression of RIG-I (Retinoic acid-Inducible Gene-I) in mouse macrophages dose-dependently, thereby suppressing the transcription of IFN-β, with lower effects than those of ribavirin. | 28957692 | 2017 |
|
0.060 | Biomarker | disease | BEFREE | Human Respiratory Syncytial Virus NS 1 Targets TRIM25 to Suppress RIG-I Ubiquitination and Subsequent RIG-I-Mediated Antiviral Signaling. | 30558248 | 2018 |
|
0.060 | Biomarker | disease | BEFREE | Different types of effective fractions from Radix Isatidis revealed a multiple-target synergy effect against respiratory syncytial virus through RIG-I and MDA5 signaling pathways, a pilot study to testify the theory of superposition of traditional Chinese Medicine efficacy. | 31051218 | 2019 |