DDX58, DExD/H-box helicase 58, 23586

N. diseases: 144; N. variants: 10
Disease: Zika Virus Infection ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0276289
Disease: Zika Virus Infection
Zika Virus Infection 		0.050 Biomarker disease BEFREE ZIKV infection (African lineage MR766) in human dermal fibroblasts, human epidermal keratinocytes, and HaCaT keratinocytes resulted in distinct expression changes in RIG-I-like receptors, such as RIG-I and MDA5. 30218650 2019
CUI: C0276289
Disease: Zika Virus Infection
Zika Virus Infection 		0.050 Biomarker disease BEFREE Zika virus antagonizes interferon response in patients and disrupts RIG-I-MAVS interaction through its CARD-TM domains. 31183075 2019
CUI: C0276289
Disease: Zika Virus Infection
Zika Virus Infection 		0.050 Biomarker disease BEFREE We show that the NS3 protein of Zika virus (ZIKV) antagonizes antiviral gene induction by RIG-I and MDA5 by binding to and sequestering the scaffold proteins 14-3-3ϵ and 14-3-3η. 31600501 2019
CUI: C0276289
Disease: Zika Virus Infection
Zika Virus Infection 		0.050 Biomarker disease BEFREE Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling. 29572905 2018
CUI: C0276289
Disease: Zika Virus Infection
Zika Virus Infection 		0.050 Biomarker disease BEFREE We identified a mechanism whereby Zika virus sensing via the RIGI-IRF3 pathway resulted in IFN-β-mediated upregulation of MHC-I molecules and inhibition of NK cell activity. 28878071 2017