DDX58, DExD/H-box helicase 58, 23586

N. diseases: 144; N. variants: 10
Disease: Primary malignant neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.070 Biomarker group BEFREE Harnessing the immune system to fight cancer with Toll-like receptor and RIG-I-like receptor agonists. 30836160 2020
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.070 Biomarker group BEFREE In this study, we present comprehensive data validating the concept and utility of treatment with synthetic RIG-I agonist ppp-RNA for the therapy of human cancer, with melanoma as potential entry indication amenable to intratumoral treatment. 31515294 2019
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.070 AlteredExpression group BEFREE Our present findings showed that the decreased RIG-I expression significantly correlated with patients' prognoses, and such down-regulation could promote the cell invasion in this malignancy. 30250402 2018
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.070 Biomarker group BEFREE RIG-I function could be fortified under hypoxia by the combined use of 3pRNA with antioxidants.<i>Cancer </i>. 28468914 2017
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.070 Biomarker group BEFREE Therefore, RIG-I is a promising drug target for the treatment of cancer as well as multiple sclerosis. 26392348 2015
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.070 AlteredExpression group BEFREE RIG-I is abundantly expressed both in poorly-differentiated primary cancer and lymph node metastasis, but not in normal adjacent tissues. 23484008 2013
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.070 AlteredExpression group BEFREE RIG1 is expressed in high levels in well-differentiated tissues, but its expression is decreased in cancer tissues and cancer cell lines. 22960220 2012