|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inhibition of Ongoing Influenza A Virus Replication Reveals Different Mechanisms of RIG-I Activation.
|
30602605 |
2019 |
|
Influenza A
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here, RIG-I-knockout 293T cells were used to package the IFN-sensitive influenza A/WSN/33 (H1N1) virus expressing the mutant NS1 R38A/K41A.
|
29765910 |
2018 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data further suggest that NS1 also posttranscriptionally alters RIG-I pre-mRNA processing by binding to the RIG-I pre-mRNA.<b>IMPORTANCE</b> A key virulence factor of influenza A virus is the NS1 protein, which inhibits various cellular processes to facilitate viral gene expression.
|
30258002 |
2018 |
|
Influenza A
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results showed that IAV infection led to low body weight and high viral load and high expression of RIG-I, IRF3, IRF7, and NF-<i>κ</i>B mRNA, as well as RIG-I and NF-<i>κ</i>B p65 protein.
|
29681974 |
2018 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
The nuclear RIG-I, along with its cytoplasmic counterpart, senses influenza A virus (IAV) nuclear replication leading to a cooperative induction of type I interferon response.
|
30097581 |
2018 |
|
Influenza A
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MCPIP1 attenuates the innate immune response to influenza A virus by suppressing RIG-I expression in lung epithelial cells.
|
28892164 |
2018 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Threonine 80 phosphorylation of non-structural protein 1 regulates the replication of influenza A virus by reducing the binding affinity with RIG-I.
|
27376632 |
2017 |
|
Influenza A
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
RIG-I overexpression restored the innate immune response in CS-exposed mice to that seen in sham-exposed WT mice during IAV infection, and is likely responsible for enhanced survival in RIG-I TG mice as restoration preceded death of the animals.
|
28865477 |
2017 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated retinoic acid-inducible protein I (RIG-I) and interferon (IFN) induction by influenza A virus (IAV) in human bronchial epithelial cells (HBEC) isolated from smokers or nonsmokers.
|
27604339 |
2016 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
We will highlight three major functions of RIG-I against FLUAV: IFN induction, signaling-independent direct antiviral activity, and assembly of an inflammasome.
|
27318973 |
2016 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, Duox2-derived ROS are necessary for the innate immune response and trigger the induction of RIG-I and MDA5 to resist IAV infection in human nasal epithelium and mouse nasal mucosa.
|
25751630 |
2015 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, these findings indicate that viral RNA polymerase components PB2, PB1, and PA directly target RIG-I, but the exact biological significance of these interactions in the replication and pathogenicity of influenza A virus needs to be further clarified.
|
24942585 |
2014 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 protein.
|
23209422 |
2012 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Influenza A(H1N1)pdm09 virus suppresses RIG-I initiated innate antiviral responses in the human lung.
|
23185463 |
2012 |
|
Influenza A
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, expression of the RNA receptors Rig-I and MDA5 was increased upon stimulation with virion extracted vRNA or IAV infection.
|
21899695 |
2011 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we report that the influenza A virus nonstructural protein 1 (NS1) specifically inhibits TRIM25-mediated RIG-I CARD ubiquitination, thereby suppressing RIG-I signal transduction.
|
19454348 |
2009 |