BACE1, beta-secretase 1, 23621

N. diseases: 120; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 AlteredExpression disease BEFREE Ectopic expression of the dominant negative SREBP1 mutant and knocking-down SREBP1 expression significantly reduced the palmitate-induced increase in BACE1 expression and subsequent Aβ genesis in mouse N2a neuroblastoma cells. 30569418 2019
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 AlteredExpression disease BEFREE Here, we show that peroxisome proliferator-activated receptor delta (PPARδ) decreases BACE1 expression by up-regulating suppressor of cytokine signaling 1 (SOCS1) in SH-SY5Y neuroblastoma cells. 31063584 2019
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 AlteredExpression disease BEFREE It was found that reconstituted lipoprotein-associated apoE isoforms promoted the increase of Aβ production and oligomerization and of BACE1 levels in human neuroblastoma SK-N-SH cells, with an apoE4 ≥ apoE3 > apoE2 potency rank order. 29743204 2018
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 AlteredExpression disease BEFREE To clarify this issue, the effect of roasting coffee beans on β-secretase (BACE1) expression in human neuroblastoma SH-SY5Y cells is investigated. 30144352 2018
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 AlteredExpression disease BEFREE The results indicate that berberine reduces Aβ generation and decreases the expression of β-site APP cleaving enzyme-1 (BACE1) via activating AMPK in N2a mouse neuroblastoma cells stably expressing human Swedish mutant APP695 (N2a/APP695sw), N2a cells, and primary cultured cortical neurons. 28822725 2017
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 AlteredExpression disease BEFREE Using the human-derived neuroblastoma cell line SK-N-MC, the results show that ethanol up-regulated BACE1 expression in a dose-dependent manner. 28668332 2017
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 AlteredExpression disease BEFREE PPAR-α agonist regulates amyloid-β generation via inhibiting BACE-1 activity in human neuroblastoma SH-SY5Y cells transfected with APPswe gene. 26092426 2015
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 AlteredExpression disease BEFREE And the manipulated high level of miR-29c with miR-29c mimics transfection significantly reduced the protein level of BACE1 and APPβ accumulation in human neuroblastoma SH-SY5Y cells. 25973041 2015
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 Biomarker disease BEFREE By utilizing neuroblastoma N2a cells transfected with Swedish mutated human amyloid precursor protein (APP) (N2a/APPswe) and wild-type APP (N2a/APPwt) as cellular models of AD, we examined the alterations of histone acetylation at the promoter regions of PS1 and BACE1 in these cells. 25051175 2014
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 AlteredExpression disease BEFREE In this study, we determined the extent to which SIRT1 expression and activity regulate the leptin-induced attenuation in BACE1 expression and Aβ levels in cultured human neuroblastoma SH-SY5Y cells. 24874077 2014
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 AlteredExpression disease BEFREE Similar regulatory mechanisms were found for the COX-2 regulation of BACE-1 expression in neuroblastoma cells. 24621265 2014
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 Biomarker disease BEFREE These results suggest that CA reduces Aβ42 production by activating TACE without promoting BACE1 in human neuroblastoma cells. 23257508 2013
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 AlteredExpression disease BEFREE In the present study, we show that the cholesterol oxidation product 27-hydroxycholesterol (27-OHC) increases BACE1 and Aβ levels in human neuroblastoma SH-SY5Y cells. 23951005 2013
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 AlteredExpression disease BEFREE Here, we show that the Aβ1-42-mediated increase in BACE1 expression is accompanied by a decrease in ubiquitin C-terminal hydrolase L1 (Uch-L1) expression and activity in different cellular models such as neuroblastoma SH-SY5Y as well as NT(2) neuronal cells. 22726800 2012
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 AlteredExpression disease BEFREE BACE1 protein levels are increased in response to OS in SH-SY5Y cells and specific inhibitions of PKR-eIF2α attenuate BACE1 protein levels in this model. 22306812 2012
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 Biomarker disease BEFREE In this study, we investigated the effects of oxidative stress on the BACE1 and gamma-secretase components in lipid rafts using human neuroblastoma SH-SY5Y cells exposed to ethacrynic acid (EA), a compound that induces cellular glutathione depletion. 19885829 2010
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 Biomarker disease BEFREE Analysis of wild type and mutant BACE1 expressed in BACE1 null fibroblasts and neuroblastoma cells revealed that S-palmitoylation neither contributes to protein stability nor subcellular localization of BACE1. 19074428 2009
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 AlteredExpression disease BEFREE Moreover, the levels of mature BACE1 were increased in human neuroblastoma cell line, SH-SY5Y, stably expressing wild-type PS1, compared to native cells. 17075903 2007
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 Biomarker disease BEFREE However, Na(v)1.1 is retained inside the cells and cell surface expression of the Na(v)1 alpha-subunits and sodium current densities are markedly reduced in both neuroblastoma cells and adult hippocampal neurons from BACE1-transgenic mice. 17576410 2007
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 AlteredExpression disease BEFREE We have investigated the effect of hypoxia (0% O(2), 24h) and reoxygenation (0h, 12h and 24h after 24h hypoxia) on BACE1 mRNA and protein levels in human neuroblastoma SH-SY5Y cells. 16901640 2006