Alzheimer's Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The authors present a study on the association of PRNP and PRND gene polymorphisms with the occurrence and age at onset of Alzheimer's disease (AD).
|
14745079 |
2004 |
Alzheimer's Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
PRND 3'UTR polymorphism may be associated with behavioral disturbances in Alzheimer disease.
|
22453181 |
2012 |
Creutzfeldt-Jakob disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the prion protein gene and in the doppel gene increase susceptibility for Creutzfeldt-Jakob disease.
|
14970845 |
2004 |
Creutzfeldt-Jakob disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
To answer the question of whether there are any polymorphisms within the PrP-like protein gene (Prnd) that might cause or be involved in the development of TSEs, we investigated the complete open reading frame of the human Prnd gene from 58 patients who had died of genetic or sporadic Creutzfeldt-Jakob disease (CJD), Alzheimer's disease or other neurological disorders and from 111 controls.
|
11702213 |
2001 |
Creutzfeldt-Jakob Disease, Sporadic
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
To answer the question of whether there are any polymorphisms within the PrP-like protein gene (Prnd) that might cause or be involved in the development of TSEs, we investigated the complete open reading frame of the human Prnd gene from 58 patients who had died of genetic or sporadic Creutzfeldt-Jakob disease (CJD), Alzheimer's disease or other neurological disorders and from 111 controls.
|
11702213 |
2001 |
Anxiety
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In AD patients, carrier status of the T allele of the 3'UTR (untranslated region) PRND polymorphism was associated with an increased cumulative behavioral load and an elevated risk for delusions, anxiety, agitation/aggression, apathy and irritability/emotional ability.
|
22453181 |
2012 |
Anxiety Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In AD patients, carrier status of the T allele of the 3'UTR (untranslated region) PRND polymorphism was associated with an increased cumulative behavioral load and an elevated risk for delusions, anxiety, agitation/aggression, apathy and irritability/emotional ability.
|
22453181 |
2012 |
Delusions
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In AD patients, carrier status of the T allele of the 3'UTR (untranslated region) PRND polymorphism was associated with an increased cumulative behavioral load and an elevated risk for delusions, anxiety, agitation/aggression, apathy and irritability/emotional ability.
|
22453181 |
2012 |
Apathy
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
In AD patients, carrier status of the T allele of the 3'UTR (untranslated region) PRND polymorphism was associated with an increased cumulative behavioral load and an elevated risk for delusions, anxiety, agitation/aggression, apathy and irritability/emotional ability.
|
22453181 |
2012 |
Abnormal behavior
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
PRND 3'UTR polymorphism may be associated with behavioral disturbances in Alzheimer disease.
|
22453181 |
2012 |
Other Creutzfeldt-Jakob disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To answer the question of whether there are any polymorphisms within the PrP-like protein gene (Prnd) that might cause or be involved in the development of TSEs, we investigated the complete open reading frame of the human Prnd gene from 58 patients who had died of genetic or sporadic Creutzfeldt-Jakob disease (CJD), Alzheimer's disease or other neurological disorders and from 111 controls.
|
11702213 |
2001 |
Behavioral and psychological symptoms of dementia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
In this research paper, our aim is to evaluate the association between the APOE, CYP46, PRNP and PRND genes and the profile of neuropsychiatric symptoms in Polish subjects with AD and mild cognitive impairment (MCI).
|
22453181 |
2012 |
Irritable Mood
|
0.300 |
Biomarker
|
phenotype |
PSYGENET |
PRND 3'UTR polymorphism may be associated with behavioral disturbances in Alzheimer disease.
|
22453181 |
2012 |
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our study in the Spanish population argues against the hypothesis that the PRND gene is causally related to AD.
|
12399017 |
2002 |
Astrocytoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Altered cellular distribution and sub-cellular sorting of doppel (Dpl) protein in human astrocytoma cell lines.
|
18607068 |
2008 |
Astrocytoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that the PRND gene might be a useful molecular marker in astrocytoma progression and in tumor grade definition.
|
15274317 |
2004 |
Ataxia
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
These lines of Prnp0/0 mice exhibit ataxia and apoptosis of cerebellar cells, indicating that ectopic synthesis of Dpl protein is toxic to CNS neurons: this inference has now been confirmed by the construction of transgenic mice expressing Dpl under the direct control of the PrP promoter.
|
11716303 |
2001 |
Ataxia
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Doppel protein has been discovered in prnp knock-out mouse lines, with overproduction of this protein in the brain causing ataxia and neurodegeneration.
|
12586339 |
2003 |
Ataxia
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
These lines of Prnp(0/0) mice exhibit ataxia and apoptosis of cerebellar cells, indicating that ectopic synthesis of Dpl protein is toxic to central nervous system neurons: this inference has now been confirmed by the construction of transgenic mice expressing Dpl under the direct control of the PrP promoter.
|
11574147 |
2001 |
Cerebellar Ataxia
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Doppel protein has been discovered in prnp knock-out mouse lines, with overproduction of this protein in the brain causing ataxia and neurodegeneration.
|
12586339 |
2003 |
Cerebellar Ataxia
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
These lines of Prnp(0/0) mice exhibit ataxia and apoptosis of cerebellar cells, indicating that ectopic synthesis of Dpl protein is toxic to central nervous system neurons: this inference has now been confirmed by the construction of transgenic mice expressing Dpl under the direct control of the PrP promoter.
|
11574147 |
2001 |
Cerebellar Ataxia
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
These lines of Prnp0/0 mice exhibit ataxia and apoptosis of cerebellar cells, indicating that ectopic synthesis of Dpl protein is toxic to CNS neurons: this inference has now been confirmed by the construction of transgenic mice expressing Dpl under the direct control of the PrP promoter.
|
11716303 |
2001 |
Creutzfeldt-Jakob Disease, Sporadic
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our study evaluated previous findings of the association of SNPs in the PRNP and PRND genes in the largest cohorts for association study in sCJD to date, and extends previous findings by defining for the first time the haplotypes associated with sCJD in a large population of the German CJD surveillance study.
|
17047093 |
2006 |
Childhood Astrocytoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that the PRND gene might be a useful molecular marker in astrocytoma progression and in tumor grade definition.
|
15274317 |
2004 |
Childhood Astrocytoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Altered cellular distribution and sub-cellular sorting of doppel (Dpl) protein in human astrocytoma cell lines.
|
18607068 |
2008 |