|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Also, the siRNA-MALAT-1 group had a decreased tumor volume and weight in the subcutaneous tumor xenograft model in nude mice, and increased LC3-II/LC3-I expression but decreased p62 expression in tumor tissues when compared with the blank group and the siNC group (all P<0.05).
|
28292022 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Mechanistically, the Lmdd-MPFG vaccine activates the NF-κB pathway in the tumor-associated macrophages (TAMs) through the TLR2 and MyD88 pathway, and recruits p62 to activate the autophagy pathway.
|
31659256 |
2020 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Both the metastatic and recurrent tumor tissues expressed less p62 than the patient-matched primary tumor.
|
29699801 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
High levels of p62 c-myc were associated with well differentiated tumours.
|
2679850 |
1989 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In immunohistochemical analysis, AGG-treated tumor displays higher caspase 3 expression and less p62 and NRF2 expression in comparison to the control.
|
31715238 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Although recent empirical observations demonstrated that p62 is overexpressed in variety of human tumors, a mechanism of p62 overexpression is not known.
|
24121124 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
ATF4 upregulation by p62 deficiency in the stroma activates glucose carbon flux through a pyruvate carboxylase-asparagine synthase cascade that results in asparagine generation as a source of nitrogen for stroma and tumor epithelial proliferation.
|
28988820 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Together, our studies demonstrate that p62 and autophagy synergize to promote tumor growth, suggesting that inhibition of both pathways could be more effective than targeting either alone for cancer therapy.
|
24888590 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Through activating the protein kinase C iota (PKCiota)-S-phase kinase-associated protein 2 (SKP2) signaling pathway, p62 enhances cell apoptosis resistance and colony formation in vitro and tumor growth in mouse models.
|
29551772 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Overexpression of Beclin 1, LC3 and p62 proteins were detected in 69%, 79% and 85% of tumors, respectively.
|
23192274 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings show how p62 helps maintain intracellular pools of GSH needed to limit mitochondrial dysfunction in tumor cells with elevated mTORC1, highlighting p62 and redox homeostasis as nodal vulnerabilities for therapeutic targeting in these tumors.<i></i>.
|
28512249 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Additionally, autophagy markers LC3II/I (<i>p</i> < 0.05), Beclin-1 (<i>p</i> < 0.01), and P62 (<i>p</i> < 0.05) increased in the skeletal muscle of tumor-bearing mice.
|
30713500 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here we investigated some mechanistic aspects of these effects.In mammary tumors bearing-dogs, i.m. injections of p62 plasmid reduced tumor sizes and their aggressive potential in 5 out of 6 animals, with one carcinoma switching to adenoma.
|
31754084 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
As a tumor-suppression mechanism, autophagy deficiency is common in tumors, which results in aberrant accumulation of p62 and activates p62-regulated pathways, such as activation of mTOR in nutrient sensing, and the activation of the Keap1-Nrf2 pathway for antioxidant stress, which are associated with cancer development.
|
31802896 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
NF-κB Signaling Activation Induced by Chloroquine Requires Autophagosome, p62 Protein, and c-Jun N-terminal Kinase (JNK) Signaling and Promotes Tumor Cell Resistance.
|
28082672 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunohistochemically, c-myc p62 positive tumor cells were found in 24 cases (46.2%), while the stromal cells around the tumor cells showed c-myc p62 immunoreactivity in all cases (100%).
|
2188234 |
1990 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
<i>Apc<sup>Min/+</sup></i> mice when infected with CR and <i>BLT1<sup>-/-</sup>;Apc<sup>Min/+</sup></i> mice, exhibited similar co-localization of p62 with LC3B and Dclk1 within the tumors.
|
31040926 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, p62 is an anti-inflammatory tumor suppressor that acts through the modulation of metabolism in the tumor stroma.
|
25002027 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The p62 proteins were elevated and mainly located in the cytoplasm in some types of tumor compared with the normal tissues.
|
30410612 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Correlation of quantitative dot blotting of tumour mRNA to flow cytometric p62 c-myc expression was good (r = 0.87, P less than 0.01).
|
1874294 |
1991 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In mice, p62 up-regulation promotes tumor cell growth and metastasis in a Twist1-dependent manner.
|
24927592 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, the role of p62 in tumour development depends on the interacting factors it recruits and its precise regulatory mechanism remains unclear.
|
30941888 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Not surprisingly, p62 is required for tumor transformation owing to its roles as a key molecule in nutrient sensing, as a regulator and substrate of autophagy, as an inducer of oxidative detoxifying proteins, and as a modulator of mitotic transit and genomic stability; all crucial events in the control of cell growth and cancer.
|
22424619 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, we demonstrated that XIAP-enhanced tumor growth is dependent on depletion of p62 in vivo.
|
30275562 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations.
|
26268733 |
2015 |