PLA2G15, phospholipase A2 group XV, 23659

N. diseases: 170; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.100 Biomarker disease BEFREE In this investigator-initiated, randomised, open-label, assessor-blinded, multicentre trial (TROPICAL-ACS) done at 33 sites in Europe, patients were enrolled if they had biomarker-positive acute coronary syndrome with successful PCI and a planned duration of dual antiplatelet treatment of 12 months. 28855078 2017
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.100 GeneticVariation disease BEFREE However, it is not easy to make a complete changeover to NOACs in real-world clinical practice because NOACs still have challenges in specific patient populations (eg, Asian patients, NVAF patients presenting with acute coronary syndrome [ACS], dialysis patients with NVAF, patients with cancer-associated VTE, etc.). 31632045 2019
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.100 Biomarker disease BEFREE Analyses were repeated stratified by whether or not the procedure had been performed in the setting of an acute coronary syndrome ( ACS ). 30642222 2019
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.100 GeneticVariation disease BEFREE Extracted data included baseline cardiac status, dosimetric parameters to the whole heart (WH) and cardiac substructures, and the development of post-CRT symptomatic cardiac events (acute coronary syndrome [ACS], arrhythmia, pericardial effusion, pericarditis, and congestive heart failure [CHF]). 29883836 2018
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.100 Biomarker disease BEFREE The difference in clinical presentations (acute coronary syndrome [ACS] and stable coronary artery disease [SCAD]) and related angiographic morphologies of sirolimus-eluting stent (SES) failure requiring target lesion revascularization (TLR) during early-term (<1year), late-term (1-5years), and very late-term periods (>5years) remains unknown. 28545849 2017
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.100 Biomarker disease BEFREE Risk stratification after percutaneous coronary intervention (PCI) is mainly based on demographics and clinical presentation (stable coronary artery disease [CAD] vs. acute coronary syndromes [ACS]). 30041804 2018
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.100 GeneticVariation disease BEFREE A total of 1,121,359 cases (103,887 EVT cases for critical limb ischemia [CLI] or intermittent claudication and 1,017,472 PCI cases for acute coronary syndrome [ACS] or stable angina) were analyzed. 31730004 2019
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.100 Biomarker disease BEFREE We enrolled 111 patients (82 with stable CAD and 29 with acute coronary syndromes [ACS]) who underwent coronary angiography. 28511772 2017
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.100 Biomarker disease BEFREE (Assessment of Distal Protection Device in Patients at High Risk for Distal Embolism in Acute Coronary Syndrome [ACS] [VAMPIRE3]; NCT01460966). 30077678 2018
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.100 Biomarker disease BEFREE The TRANSLATE-ACS study (Treatment with Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events after Acute Coronary Syndrome) assessed employment status at baseline and 1 year among 9319 patients with MI (mean age, 60.8 years; SD, 11.3; 27.3% women) enrolled at 233 US hospitals. 29895612 2018
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.100 Biomarker disease BEFREE Each offers a relative efficacy benefit (dual antiplatelet therapy [DAPT] is more effective than OAC alone in reducing cardiovascular death, myocardial infarction, stent thrombosis, and ischemic coronary events in a population with acute coronary syndromes [ACS]), but with a relative compromise (DAPT is significantly inferior to OAC for the prevention of stroke/systemic embolism in an AF population at increased risk of stroke). 30404748 2018
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.100 GeneticVariation disease BEFREE Background Obstructive sleep apnea ( OSA ) is a novel risk factor for acute coronary syndrome ( ACS ). 30371252 2018
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.100 Biomarker disease BEFREE Background The prognostic significance of obstructive sleep apnea ( OSA ) in patients with acute coronary syndrome ( ACS ) in the contemporary era is unclear. 30636505 2019
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.100 Biomarker disease BEFREE Conflicting evidence exists about the impact of marital status on the outcomes of patients with acute coronary syndrome ( ACS ). 31266391 2019
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.100 GeneticVariation disease BEFREE Dialysis patients had more comorbidities than nondialysis patients and higher rates of complications including in-hospital mortality (3.3% vs. 1.5%, respectively, in the acute coronary syndrome [ACS] cohort, 0.2% vs. 0.1% in the non-ACS cohort) and bleeding complications requiring blood transfusion (1.1% vs. 0.4% in ACS, 0.5% vs. 0.2% in non-ACS). 30467967 2019
CUI: C0340288
Disease: Stable angina
Stable angina
0.090 GeneticVariation disease BEFREE Prospective cohort study of 75 stable patients with CAD and 3 differing clinical profiles (stable angina [SA]; remote myocardial infarction [MI]; repetitive acute coronary syndrome [ACS]) and 25 controls without angiographic CAD, each with 15 hs-cTnT measurements over 1 year. 31679620 2019
CUI: C0340288
Disease: Stable angina
Stable angina
0.090 Biomarker disease BEFREE Patients were grouped according to the form of CAD (ACS vs. stable angina) and the number of diseased vessels. 22773402 2012
CUI: C0340288
Disease: Stable angina
Stable angina
0.090 Biomarker disease BEFREE We evaluated 145 native coronary lesions (89 lesions with stable angina pectoris [SAP] and 56 with acute coronary syndrome [ACS]). 28233628 2017
CUI: C0340288
Disease: Stable angina
Stable angina
0.090 GeneticVariation disease BEFREE These 4215 procedures were evaluated for three different categories: diagnostic CA (Group I), PCI in patients with stable angina (Group II), and PCI in patients with ACS (Group III). 31264653 2019
CUI: C0340288
Disease: Stable angina
Stable angina
0.090 Biomarker disease BEFREE Genotyping was performed in 1,598 CAD subjects (ACS or stable angina) and 332 controls. 17044867 2006
CUI: C0340288
Disease: Stable angina
Stable angina
0.090 Biomarker disease BEFREE The patients were divided in 4 groups: patients without coronary artery disease (control group), patients with stable angina pectoris (SAP group), patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS group), and patients with ST-segment elevation acute myocardial infarction group (STEMI group). 30898992 2019
CUI: C0340288
Disease: Stable angina
Stable angina
0.090 Biomarker disease BEFREE Gene expression profiles were determined in RNA pools from resting platelets of patients with stable angina (SA, n = 14) or NSTE-ACS (n = 15) using a glass microarray platform. 21420725 2011
CUI: C0340288
Disease: Stable angina
Stable angina
0.090 Biomarker disease BEFREE We measured baseline sEPCR levels in 1673 individuals with CAD (521 with acute coronary syndrome [ACS] and 1152 with stable angina pectoris [SAP]) from the AtheroGene cohort. 23136988 2012
CUI: C0340288
Disease: Stable angina
Stable angina
0.090 Biomarker disease BEFREE Data in SA and ACS groups were replicated in an independent population of 482 stable angina patients (rSA) and of 675 ACS patients, respectively. 22575314 2012
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.090 Biomarker disease BEFREE External validation in stable CAD (c = 0.65) and ACS (c = 0.68) demonstrated comparable performance. 31623766 2019