Malignant neoplasm of breast
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Thereafter, by performing macroarray and reverse transcriptase quantitative-polymerase chain reaction (RT-qPCR) experiments, gabarapl1 expression was quantified in several histological breast tumour types and in a retrospective cohort of 265 breast cancers.
|
20197771 |
2010 |
Malignant neoplasm of breast
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
To test this hypothesis, we knocked down GABARAPL1 expression in the breast cancer MDA-MB-436 cell line by shRNA.
|
24879149 |
2014 |
Malignant neoplasm of breast
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Gene expression analyses revealed that GABARAPL1 and MAP1LC3C/LC3C transcripts were less abundant in breast cancer and non-small cell lung cancers than in matched normal tissue controls; ATG4D transcripts were increased in lung squamous cell carcinoma, as were ATG16L2 transcripts in kidney cancer.
|
26208877 |
2015 |
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
Our laboratory previously demonstrated that GABARAPL1 associates with autophagic vesicles, regulates autophagic flux and acts as a tumor suppressor protein in breast cancer.
|
28915569 |
2017 |
Malignant neoplasm of breast
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Our data demonstrated that a specific decrease of GABARAPL1 expression in breast cancers was associated with both DNA methylation and histone deacetylation and that CREB-1 recruitment on GABARAPL1 promoter was required for GABARAPL1 expression.
|
26474850 |
2015 |
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
GABARAPL1 acts as a potential marker and promotes tumor proliferation and metastasis in triple negative breast cancer.
|
29088804 |
2017 |
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
MicroRNA-133a-3p targets GABARAPL1 to block autophagy-mediated glutaminolysis, further repressing gastric cancer growth and metastasis.
|
30572959 |
2018 |
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Using a genome wide shRNA screen, we identified GABARAPL1 as a potential CaP metastasis suppressor.
|
27966458 |
2017 |
Neoplasm Metastasis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
In univariate or multivariate analysis, gabarapl1 expression did not disclose any difference in metastasis risk in lymph node-negative patients.
|
20197771 |
2010 |
Breast Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Our laboratory previously demonstrated that GABARAPL1 associates with autophagic vesicles, regulates autophagic flux and acts as a tumor suppressor protein in breast cancer.
|
28915569 |
2017 |
Breast Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Gene expression analyses revealed that GABARAPL1 and MAP1LC3C/LC3C transcripts were less abundant in breast cancer and non-small cell lung cancers than in matched normal tissue controls; ATG4D transcripts were increased in lung squamous cell carcinoma, as were ATG16L2 transcripts in kidney cancer.
|
26208877 |
2015 |
Breast Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
The autophagy GABARAPL1 gene is epigenetically regulated in breast cancer models.
|
26474850 |
2015 |
Breast Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
To test this hypothesis, we knocked down GABARAPL1 expression in the breast cancer MDA-MB-436 cell line by shRNA.
|
24879149 |
2014 |
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Our results demonstrate for the first time that GABARAPL1 plays different regulatory functions during early and late stages of autophagy, independently or not of its conjugation to autophagosomes, but its tumor suppressive function appeared to be independent of its conjugation to autophagic vesicles.
|
28915569 |
2017 |
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Taken together, our results suggested that GABARAPL1 as a tumor repressor inhibits Wnt signaling via mediating Dvl2 degradation through the autophagy pathway.
|
21691068 |
2011 |
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Our findings demonstrate that GABARAPL1 acts as a tumor promoter in TNBC partly through MTDH.
|
29088804 |
2017 |
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
We show here that silencing FOXOs leads to reduced GABARAPL1 expression and enhanced invasion in LNCaP cells.
|
27966458 |
2017 |
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
We have identified ATG8 in Plasmodium liver forms as an important effector that controls the development and fate of organelles, e.g., the clearance of micronemes that are required for hepatocyte invasion and the expansion of the apicoplast that produces many metabolites indispensable for parasite replication.
|
27353755 |
2016 |
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Decreased expression of GABARAPL1 activated procancer responses of the MDA-MB-436 cells including increased proliferation, colony formation, and invasion.
|
24879149 |
2014 |
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Moreover, Kaplan-Meier curves analysis showed that GABARAPL1 down-regulation in cancer tissues is associated with decreased disease-free survival in CaP patients.
|
27966458 |
2017 |
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
In this review article, we will outline the specific functions of this protein and also hypothesize about the roles that GABARAPL1 might have in several important biological processes such as cancer or neurodegenerative diseases.
|
21597319 |
2011 |
Malignant neoplasm of prostate
|
0.020 |
Biomarker
|
disease |
BEFREE |
GABARAPL1 Promotes AR+ Prostate Cancer Growth by Increasing FL-AR/AR-V Transcription Activity and Nuclear Translocation.
|
31803623 |
2019 |
Malignant neoplasm of prostate
|
0.020 |
Biomarker
|
disease |
BEFREE |
Elevated Gabarapl1 also represses the proliferation of prostate cancer cells.
|
26050226 |
2015 |
Prostate carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Elevated Gabarapl1 also represses the proliferation of prostate cancer cells.
|
26050226 |
2015 |
Prostate carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
GABARAPL1 Promotes AR+ Prostate Cancer Growth by Increasing FL-AR/AR-V Transcription Activity and Nuclear Translocation.
|
31803623 |
2019 |