|
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
|
0.020 |
Biomarker
|
disease |
BEFREE |
Differential Proteomic Analysis Reveals Protein Networks and Pathways that May Contribute to Helicobacter pylori FKBP-Type PPIase-Associated Gastric Diseases.
|
29148176 |
2018 |
|
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
|
0.020 |
Biomarker
|
disease |
BEFREE |
Helicobacter pylori FKBP-type PPIase promotes gastric epithelial cell proliferation and anchorage-independent growth through activation of ERK-mediated mitogenic signaling pathway.
|
25687921 |
2015 |
|
Alzheimer's Disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The present study investigated whether there was any association between genetic variation in RTN3 and PPIL2, and either risk for AD, or levels of platelet beta-secretase activity, in a large Northern Irish case-control sample.
|
19669607 |
2009 |
|
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Previous studies have shown that Pin1, a peptidylprolyl cis/trans-isomerase, may be actively involved in the regulation of Tau hyperphosphorylation in AD.
|
18635547 |
2008 |
|
Parkinson Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
The PPIase CypA colocalizes with the Parkinson's disease (PD)-associated protein α -synuclein in cells and interacts with α -synuclein oligomers.
|
31830361 |
2020 |
|
Abscess
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Previously, we identified two PPIase enzymes in <i>Staphylococcus aureus</i> (PpiB and PrsA) that are involved in the regulation of virulence determinants and have shown that PpiB contributes to <i>S. aureus</i> virulence in a murine abscess model of infection.
|
31208155 |
2019 |
|
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Analysis of tissue samples taken from breast cancer patients showed a significant correlation between the expression of PPIL2 and the degree of cancer invasion and metastasis.
|
29352246 |
2018 |
|
Malignant Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Analysis of tissue samples taken from breast cancer patients showed a significant correlation between the expression of PPIL2 and the degree of cancer invasion and metastasis.
|
29352246 |
2018 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The analysis of T1D identified one region already known to be associated with T1D (INS: p = 3.13 × 10<sup>-7</sup>) and three novel regions (RNASET2, PLEKHA1, and PPIL2; 5.42 × 10<sup>-6</sup> > p > 2.31 × 10<sup>-6</sup>).
|
29310926 |
2018 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Analysis of tissue samples taken from breast cancer patients showed a significant correlation between the expression of PPIL2 and the degree of cancer invasion and metastasis.
|
29352246 |
2018 |
|
Stomach Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Our results provided insight on the protein interaction networks and signaling pathways that may contribute to PPIase-FKBP-associated gastric diseases and may lead to a better understanding of the mechanisms indicating the oncogenic effects of H. pylori PPIase-FKBP.
|
29148176 |
2018 |
|
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Analysis of tissue samples taken from breast cancer patients showed a significant correlation between the expression of PPIL2 and the degree of cancer invasion and metastasis.
|
29352246 |
2018 |
|
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Analysis of tissue samples taken from breast cancer patients showed a significant correlation between the expression of PPIL2 and the degree of cancer invasion and metastasis.
|
29352246 |
2018 |
|
Primary malignant neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Analysis of tissue samples taken from breast cancer patients showed a significant correlation between the expression of PPIL2 and the degree of cancer invasion and metastasis.
|
29352246 |
2018 |
|
Amyotrophic Lateral Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results indicates that extracellular PPIA is a promising druggable target for ALS and support further studies to develop a therapy to arrest or slow the progression of the disease in patients.<b>SIGNIFICANCE STATEMENT</b> We provide evidence that extracellular cyclophilin A, also known as peptidylprolyl cis-/trans-isomerase A (PPIA), is a mediator of the neuroinflammatory reaction in amyotrophic lateral sclerosis (ALS) and is toxic for motor neurons.
|
28011744 |
2017 |
|
Arthritis aggravated
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our findings provide evidence that PPIase CypA promoted macrophages polarization toward pro-inflammatory M1 phenotype via transcriptional activating NF-κB, thus leading to aggravated arthritis.
|
28756520 |
2017 |