ALK, ALK receptor tyrosine kinase, 238

N. diseases: 519; N. variants: 41
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.700 CausalMutation disease CGI
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.700 CausalMutation disease CGI
CUI: C0334121
Disease: Inflammatory Myofibroblastic Tumor
Inflammatory Myofibroblastic Tumor 		0.700 CausalMutation disease CGI
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms 		0.610 CausalMutation group CGI
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.600 CausalMutation disease CGI
CUI: C0206180
Disease: Ki-1+ Anaplastic Large Cell Lymphoma
Ki-1+ Anaplastic Large Cell Lymphoma 		0.600 CausalMutation disease CGI
CUI: C2751681
Disease: NEUROBLASTOMA, SUSCEPTIBILITY TO, 3
NEUROBLASTOMA, SUSCEPTIBILITY TO, 3 		0.600 GeneticVariation disease CLINVAR
CUI: C2751681
Disease: NEUROBLASTOMA, SUSCEPTIBILITY TO, 3
NEUROBLASTOMA, SUSCEPTIBILITY TO, 3 		0.600 CausalMutation disease CLINVAR
CUI: C2751681
Disease: NEUROBLASTOMA, SUSCEPTIBILITY TO, 3
NEUROBLASTOMA, SUSCEPTIBILITY TO, 3 		0.600 SusceptibilityMutation disease CLINVAR
CUI: C0035412
Disease: Rhabdomyosarcoma
Rhabdomyosarcoma 		0.500 CausalMutation disease CGI
CUI: C0153633
Disease: Malignant neoplasm of brain
Malignant neoplasm of brain 		0.500 CausalMutation disease CGI
CUI: C3899155
Disease: hereditary neuroblastoma
hereditary neuroblastoma 		0.400 Biomarker disease GENOMICS_ENGLAND
CUI: C0025202
Disease: melanoma
melanoma 		0.390 CausalMutation disease CGI
CUI: C1333294
Disease: ALK positive large B-cell lymphoma
ALK positive large B-cell lymphoma 		0.360 FusionGene disease ORPHANET
CUI: C0017638
Disease: Glioma
Glioma 		0.320 CausalMutation disease CGI
CUI: C1335177
Disease: Ovarian Serous Adenocarcinoma
Ovarian Serous Adenocarcinoma 		0.310 GeneticVariation disease UNIPROT
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.300 CausalMutation disease CGI
CUI: C0027766
Disease: Nervous System Neoplasms
Nervous System Neoplasms 		0.100 Biomarker group HPO
CUI: C0241577
Disease: Elevated urinary catecholamines
Elevated urinary catecholamines 		0.100 Biomarker phenotype HPO
CUI: C2749484
Disease: NEUROBLASTOMA, SUSCEPTIBILITY TO
NEUROBLASTOMA, SUSCEPTIBILITY TO 		0.100 GeneticVariation phenotype CLINVAR Valproate-induced hepatoxicity: protective effect of L-carnitine supplementation. 2124297 1990
CUI: C0206180
Disease: Ki-1+ Anaplastic Large Cell Lymphoma
Ki-1+ Anaplastic Large Cell Lymphoma 		0.600 Biomarker disease BEFREE ALK gene products in anaplastic large cell lymphomas and Hodgkin's disease. 7655001 1995
CUI: C0019829
Disease: Hodgkin Disease
Hodgkin Disease 		0.100 AlteredExpression disease BEFREE ALK expression was not detectable in any other specimen, including all cases of HD and HD-like type ALC lymphoma as well as secondary ALC lymphomas. 7655001 1995
CUI: C0206180
Disease: Ki-1+ Anaplastic Large Cell Lymphoma
Ki-1+ Anaplastic Large Cell Lymphoma 		0.600 Biomarker disease BEFREE Anaplastic large cell lymphomas expressing the novel chimeric protein p80NPM/ALK: a distinct clinicopathologic entity. 7655022 1995
CUI: C0553580
Disease: Ewings sarcoma
Ewings sarcoma 		0.030 AlteredExpression disease BEFREE In contrast, expression of a NPM/ALK chimeric gene was observed which was absent in the ET. 7656205 1995
CUI: C0206180
Disease: Ki-1+ Anaplastic Large Cell Lymphoma
Ki-1+ Anaplastic Large Cell Lymphoma 		0.600 Biomarker disease BEFREE NPM/ALK fusion transcripts were found in 11 of 17 (65%) classical ALCL cases but were not detected in the four primary cutaneous cases of ALCL or in the three HIV-related ALCL cases. 7662979 1995