Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
The urachal IMT occurs mainly in males and nonelderly people with ALK positive while in females with ALK negative.
|
30572472 |
2018 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
Subsequently, a biopsy demonstrated a low-grade spindle cell neoplasm compatible with inflammatory myofibroblastic tumour with immunostain positive for smooth muscle actin and desmin and negative for CD21, CD117, DOG-1, TKE-1, mdm2, CD34 and ALK.
|
29764851 |
2018 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
Anaplastic lymphoma kinase-negative uterine inflammatory myofibroblastic tumor containing the ETV6-NTRK3 fusion gene: a case report.
|
29900760 |
2018 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
EML4-ALK Rearrangement and Its Therapeutic Implications in Inflammatory Myofibroblastic Tumors.
|
29739898 |
2018 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Pseudosarcomatous myofibroblastic proliferations of the genitourinary tract have a debatable relationship with inflammatory myofibroblastic tumour (generally lacking ALK rearrangement); however, they share several overlapping features with nodular fasciitis of soft tissue.
|
29617048 |
2018 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
The dense infiltration of inflammatory cells, immunoreactivity for ALK, and identification of an ALK-related chimeric gene suggested a diagnosis of inflammatory myofibroblastic tumor.
|
28705706 |
2017 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
Fluorescent in situ hybridization confirmed the existence of ALK rearrangement in IMT tissues.
|
28923119 |
2017 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Approximately half of the inflammatory myofibroblastic tumors contain translocations that result in the over-expression of the anaplastic lymphoma kinase (ALK) gene.
|
28409069 |
2017 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
Further review revealed that although a diagnosis of IMT was considered for the ALK immunopositive myxoid leiomyoma, this diagnosis was not initially rendered only because fluorescence in situ hybridization analysis was interpreted as negative for ALK genetic rearrangement; this case is best reclassified as an IMT.
|
28490045 |
2017 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
Three of 1176 (0.26%) "leiomyomas" and 1 of 44 (2.3%) "leiomyosarcomas" were ALK IHC positive, confirmed translocated by fluorescence in situ hybridization (FISH) and therefore more appropriately classified as IMT.
|
28731868 |
2017 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
These data show that inflammatory myofibroblastic tumors of the uterus are morphologically heterogenous with frequent ALK expression and a variety of ALK fusion partners.
|
28664932 |
2017 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
Targeting ALK With Crizotinib in Pediatric Anaplastic Large Cell Lymphoma and Inflammatory Myofibroblastic Tumor: A Children's Oncology Group Study.
|
28787259 |
2017 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Uterine IMT may be identified by anaplastic lymphoma kinase overexpression, its prognosis is usually good, complete excision seems to be effective to avoid relapse and mini invasive surgery seems to be effective and safe to treat uterine IMT.
|
29310405 |
2017 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
PD-L1 expression and CD8+ tumor-infiltrating lymphocytes are associated with ALK rearrangement and clinicopathological features in inflammatory myofibroblastic tumors.
|
29163763 |
2017 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
We should examine the ALK protein expression and translocation in cases of lung cancer and IMT using an adequate ALK immunohistochemistry system.
|
29268561 |
2017 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We describe here a patient with hyper-progressive IMT with an anaplastic lymphoma kinase (ALK) fusion gene that dramatically responded to alectinib without adverse events.
|
28977547 |
2017 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Here, we report an inflammatory myofibroblastic tumor (IMT) of the urinary bladder with a novel HNRNPA1-ALK fusion.
|
28504207 |
2017 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
More recently, previously under-recognized lesions have been identified, in part due to our growing knowledge of their underlying molecular alterations: uterine inflammatory myofibroblastic tumor frequently harbors ALK rearrangements and a novel ZC3H7B-BCOR gene fusion has been described in a subset of myxoid high-grade endometrial stromal sarcomas.
|
28787279 |
2017 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Moreover, this case had a t(1;2) translocation fusing ALK and TMP3, identical to that seen in inflammatory myofibroblastic tumour.
|
27450657 |
2016 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
ALK-Positive Inflammatory Myofibroblastic Tumor of the Nipple During Pregnancy-An Unusual Presentation of a Rare Disease.
|
25772857 |
2016 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
Four had a distinctive loose myxoid appearance, nuclei with vesicular chromatin, and ALK positivity by immunohistochemistry, suggesting, suggesting inflammatory myofibroblastic tumor.
|
26866354 |
2016 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
These results suggest that a subset of ALK-negative IMTs have rearrangement of ROS1, ETV6 or NTRK3 as a possible oncogenic mechanism, and that the detection of these alterations may be of diagnostic value and helpful for determining promising therapeutic strategies.
|
26647767 |
2016 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
We describe an inflammatory myofibroblastic tumor in the lower abdominal wall of an adult male, which occurred 88days after he received an allogeneic stem cell transplant for T-lymphoblastic lymphoma, and which was positive for ALK immunohistochemistry and showed ALK gene rearrangement by fluorescence in situ hybridization.
|
27155927 |
2016 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
Subsequently, we investigated a cohort of 15 ALK-negative IMTs of various anatomic sites.
|
27259007 |
2016 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Chromoplectic TPM3-ALK rearrangement in a patient with inflammatory myofibroblastic tumor who responded to ceritinib after progression on crizotinib.
|
27742657 |
2016 |