|
Pneumonia
|
0.030 |
Biomarker
|
disease |
BEFREE |
<i>Streptococcus pneumoniae</i> is a major cause of pneumonia, wherein infection of respiratory mucosa drives a robust influx of neutrophils.We have previously shown that <i>S. pneumoniae</i> infection of the respiratory epithelium induces the production of the 12-lipoxygenase (12-LOX)-dependent lipid inflammatory mediator hepoxilin A3, which promotes recruitment of neutrophils into the airways, tissue damage, and lethal septicemia.
|
31776202 |
2020 |
|
Septicemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
<i>Streptococcus pneumoniae</i> is a major cause of pneumonia, wherein infection of respiratory mucosa drives a robust influx of neutrophils.We have previously shown that <i>S. pneumoniae</i> infection of the respiratory epithelium induces the production of the 12-lipoxygenase (12-LOX)-dependent lipid inflammatory mediator hepoxilin A3, which promotes recruitment of neutrophils into the airways, tissue damage, and lethal septicemia.
|
31776202 |
2020 |
|
Sepsis
|
0.010 |
Biomarker
|
disease |
BEFREE |
<i>Streptococcus pneumoniae</i> is a major cause of pneumonia, wherein infection of respiratory mucosa drives a robust influx of neutrophils.We have previously shown that <i>S. pneumoniae</i> infection of the respiratory epithelium induces the production of the 12-lipoxygenase (12-LOX)-dependent lipid inflammatory mediator hepoxilin A3, which promotes recruitment of neutrophils into the airways, tissue damage, and lethal septicemia.
|
31776202 |
2020 |
|
Tumor Angiogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
12-Lipoxygenase (12-LOX) metabolizes arachidonic acid to 12(S)-hydroxyeicosatetraenoic acid, or 12(S)-HETE, a proinflammatory bioactive lipid implicated in tumor angiogenesis, growth, and metastasis.
|
28011194 |
2017 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
12-Lipoxygenase (12-LOX) metabolizes arachidonic acid to 12(S)-hydroxyeicosatetraenoic acid, or 12(S)-HETE, a proinflammatory bioactive lipid implicated in tumor angiogenesis, growth, and metastasis.
|
28011194 |
2017 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
12-Lipoxygenase (12-LOX) plays a major role in the progression and metastasis of various types of cancer.
|
31371993 |
2019 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
12-Lipoxygenase (12-LOX) plays a major role in the progression and metastasis of various types of cancer.
|
31371993 |
2019 |
|
Atherogenesis
|
0.300 |
Therapeutic
|
phenotype |
CTD_human |
12/15-Lipoxygenase gene disruption and vitamin E administration diminish atherosclerosis and oxidative stress in apolipoprotein E deficient mice through a final common pathway.
|
16303615 |
2005 |
|
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
12/15-LOXs are capable of oxidizing lipoproteins (low-density lipoprotein (LDL), high-density lipoprotein (HDL)) to atherogenic forms, and functional inactivation of this enzyme in murine atherosclerosis models slows down lesion formation.
|
16270276 |
2005 |
|
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
12/15-LOXs are capable of oxidizing lipoproteins (low-density lipoprotein (LDL), high-density lipoprotein (HDL)) to atherogenic forms, and functional inactivation of this enzyme in murine atherosclerosis models slows down lesion formation.
|
16270276 |
2005 |
|
melanoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
15% of the cell population), human melanoma lines (HT168, M1, HT199, HT18 and WM35) express the platelet-type isoform of 12-LOX both at mRNA and protein levels.
|
10667390 |
1999 |
|
Lung diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
15-Lipoxygenase (15-LOX) plays a major role in many inflammatory lung diseases including chronic obstructive pulmonary disease (COPD), asthma and chronic bronchitis.
|
27836541 |
2017 |
|
Chronic Obstructive Airway Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
15-Lipoxygenase (15-LOX) plays a major role in many inflammatory lung diseases including chronic obstructive pulmonary disease (COPD), asthma and chronic bronchitis.
|
27836541 |
2017 |
|
asthma with copd
|
0.010 |
Biomarker
|
disease |
BEFREE |
15-Lipoxygenase (15-LOX) plays a major role in many inflammatory lung diseases including chronic obstructive pulmonary disease (COPD), asthma and chronic bronchitis.
|
27836541 |
2017 |
|
Vascular inflammations
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
15-Lipoxygenase-1 (ALOX15) has been implicated in vascular inflammation and disease.
|
27594770 |
2016 |
|
Adenocarcinoma
|
0.030 |
AlteredExpression
|
group |
LHGDN |
15-lipoxygenase-1 overexpression in prostate adenocarcinoma.
|
12664577 |
2002 |
|
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
15-Lipoxygenase-2 expression in human macrophages induces chemokine secretion and T cell migration.
|
18067895 |
2008 |
|
Anoxia
|
0.010 |
AlteredExpression
|
phenotype |
LHGDN |
15-Lipoxygenase-2 expression in human macrophages induces chemokine secretion and T cell migration.
|
18067895 |
2008 |
|
Heart Failure, Diastolic
|
0.300 |
Biomarker
|
disease |
CTD_human |
In Silico Analysis of Differential Gene Expression in Three Common Rat Models of Diastolic Dysfunction.
|
29556499 |
2018 |
|
Skin Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
12-LOX expression was demonstrated in cultured tumor cells and in skin tumor xenografts.
|
10667390 |
1999 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
15-Lipoxygenase type 1 (15-LO), a lipid-peroxidating enzyme implicated in physiological membrane remodeling and the pathogenesis of atherosclerosis, inflammation, and carcinogenesis, is highly regulated and expressed in a tissue- and cell-type-specific fashion.
|
15194425 |
2004 |
|
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
15-Lipoxygenase type 1 (15-LO), a lipid-peroxidating enzyme implicated in physiological membrane remodeling and the pathogenesis of atherosclerosis, inflammation, and carcinogenesis, is highly regulated and expressed in a tissue- and cell-type-specific fashion.
|
15194425 |
2004 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
15-Lipoxygenase type 1 (15-LO), a lipid-peroxidating enzyme implicated in physiological membrane remodeling and the pathogenesis of atherosclerosis, inflammation, and carcinogenesis, is highly regulated and expressed in a tissue- and cell-type-specific fashion.
|
15194425 |
2004 |
|
Adenoma of large intestine
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
15-LOX-1 gene expression is significantly reduced in both human colorectal adenomas and carcinomas and associated with decreased survival.
|
15912043 |
2005 |
|
Atherosclerosis
|
0.400 |
Therapeutic
|
disease |
CTD_human |
12/15-Lipoxygenase gene disruption and vitamin E administration diminish atherosclerosis and oxidative stress in apolipoprotein E deficient mice through a final common pathway.
|
16303615 |
2005 |